Molecular transduction in receptor-ligand systems by planar electromagnetic fields

Abstract

The coupling of a ligand with a molecular receptor induces a signal that travels through the receptor, reaching the internal domain and triggering a response cascade. In previous work on T-cell receptors and their coupling with foreign antigens, we observed the presence of planar molecular patterns able to generate electromagnetic fields within the proteins. These planes showed a coherent (synchronized) behavior, replicating immediately in the intracellular domain that which occurred in the extracellular domain as the ligand was coupled. In the present study, we examined this molecular transduction - the capacity of the coupling signal to penetrate deep inside the receptor molecule and induce a response. We verified the presence of synchronized behavior in diverse receptor-ligand systems. To appreciate this diversity, we present four biochemically different systems - TCR-peptide, calcium pump-ADP, haemoglobin-oxygen, and gp120-CD4 viral coupling. The confirmation of synchronized molecular transduction in each of these systems suggests that the proposed mechanism would occur in all biochemical receptor-ligand systems.

What a feeling - the underpinnings of physical feelings as molecular level holonomic effects.

“…The receptor-ligand complex results in molecular energy transduction through the EM field generated by mostly aromatic residues in all biochemical receptorligand systems [109]. These residues acquire a synchronized effect due to an interconnection produced by the EM field between amino acids in the protein.…”

“…This yields EM energy transfer between EM resonances. EM resonances between clouds of delocalized charges where there is collective delocalization of electrons between benzene rings and aromatic residues of amino acids are key to understanding how the brain works at the molecular level [109]. The motion of delocalized electrons in benzene rings and in aromatic residues of amino acids where the velocity is nonconstant due to the nonlinear pathways of delocalization.…”