Toxicity and phytochemistry of eight species used in the traditional medicine of sul-mato-grossense, Brazil

Abstract

The Brazilian Cerrado has several botanical species for medicinal purposes used by traditional communities and many of these plants are not included in the list of Medicinal Plants Research Program of Central Medicines. The purpose of this study was the phytochemical screening and toxicology bioassay front of Brine shrimp L. of ethanolic extracts of eight species of plants used in folk medicine of Campo Grande, Mato Grosso do Sul, Brazil. The ethanolic extracts were submitted to phytochemical screening, determination of phenolic compounds and flavonoids. Toxicological assays were carried front of Brine shrimp according to standard methodology. The analysis TLC and HPLC-DAD confirmed the predominance of phenolic compounds and derivatives, specifically for the quercetin. The most toxic was the C. affinis DC. with death at all concentrations, the A. humile A. St. Hil. showed no mortality and the other species showed intermediate toxicity. The extracts of the investigated species are rich in phenolic compounds and derivatives, specifically quercetin, and feature toxicity between moderate to high, a fact that requires attention, since much of the traditional communities rely on herbal drugs in its raw form with preventive and curative purpose, meeting the basic health care.

Uso de fitoterápicos na atualidade: uma revisão de literatura

“…Especificadamente no Brasil, há cerca de 71 espécies de fitoterápicos utilizados com fins terapêuticos, onde o Ministério da Saúde (MS) incentiva o uso dos mesmos no Sistema Único de Saúde (SUS). Contudo, destaca-se que o uso de plantas com finalidade medicinal merece atenção, pois grande parte dos estudos científicos se configuram para avaliar o potencial farmacológico e não a toxicidade (Mendonça et al, 2020). Portanto, um leque de oportunidades do campo da pesquisa em toxicidade dos fitoterápicos podem ser explorado, sendo uma alternativa para o profissional farmacêutico atuar.…”

Effect of Porophyllum ruderale (Jacq.) Cass. in the Liver of the B16-F10 Murine Melanoma Model and Antioxidant Potential

“…Among the pharmacological activities studied for the species of the genus by Porophyllum, there is the antiinflammatory potential (SOUZA et al, 2003) (LIMA-NETO, 1996, antifungal and antibacterial (RONDÓN et al, 2008), photoprotective properties (ROSA et al, 2008) stand out and are attributed to essential oils and phenolic compounds and their derivatives, potent antioxidants (MENDONÇA et al, 2020;MENDONÇA et al, 2019), potential also observed for the ethanolic extract and the hydroalcoholic solutions in the two concentrations (Table 1).…”

“…Recently, our research group carried out studies with the ethanolic extract and fractions of P. ruderale, performing a toxicological bioassay using Artemia salina (Linnaesus, 1758) (MENDONÇA et al, 2020) and antiproliferative in vitro activity with four tumoral strains, being potentially active to PC-3, HT-29 and MCF-7 (MENDONÇA et al, 2019) (KISSMAN;GROTH, 1999). Recently, our research group carried out studies with the ethanolic extract and fractions of P. ruderale, performing a toxicological bioassay using Artemia salina (Linnaesus, 1758) (MENDONÇA et al, 2020) and antiproliferative in vitro activity with four tumoral strains, being potentially active to PC-3, HT-29 and MCF-7 (MENDONÇA et al, 2019). In both studies, phytochemical analysis was performed and phenolic compounds, flavonoids and the presence of thiophenoids were evidenced.…”

Phytochemical characterization, and antioxidant and antibacterial activities of the hydroethanolic extract of Anadenanthera peregrina stem bark

“…In this context, in Brazil, there are several medicinal plants that are used as herbal medicines by the rural and urban populations (Dutra et al, 2016;Pio et al, 2019). A single species can produce numerous chemical compounds with diverse pharmacological activities (Mendonça et al, 2019), including antibacterial (Pandini et al, 2018;Emre et al, 2020;Pacheco et al, 2020), anti-inflammatory (Ribeiro et al, 2018;Almohawes and Alruhaimi, 2020), antioxidant (Barth et al, 2018;Pontes et al, 2019;Vale et al, 2019), wound-healing properties (Ribeiro Neto et al, 2020), antihyperglycemic effect (Silva et al, 2020), and cardiovascular activity (Moreira et al, 2019).…”