2021
DOI: 10.1590/1518-8345.3310.3385
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Abstract: Objective: to evaluate the effectiveness of the 50 IU/mL heparin solution compared to the 0.9% isotonic saline solution in preventing occlusion of the double lumen Hickman® catheter, 7 and 9 French, in patients undergoing hematopoietic stem cell transplantation. Method: a triple-blind randomized clinical trial. 17 double-lumen catheters (heparin group: n=7 and 0.9% isotonic saline group: n=10) were analyzed in which the two catheter routes were evaluated separately, totaling 34 lumens. The outcome variables w… Show more

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Cited by 7 publications
(2 citation statements)
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“…It relies on flushing 5 mL of 0.9% sodium chloride, and discarding 5 mL of blood, or six times that of the catheter dead space volume, before specimen collection. UFH solution is also used to prevent catheter occlusion and infection, but may contaminate the collected blood samples [5,33]. In this and similar situations, it is impossible to correctly assess the anticoagulation of a DOAC alone.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It relies on flushing 5 mL of 0.9% sodium chloride, and discarding 5 mL of blood, or six times that of the catheter dead space volume, before specimen collection. UFH solution is also used to prevent catheter occlusion and infection, but may contaminate the collected blood samples [5,33]. In this and similar situations, it is impossible to correctly assess the anticoagulation of a DOAC alone.…”
Section: Discussionmentioning
confidence: 99%
“…A problem with measuring DOACs' activity may arise if blood samples also contain heparins, because of the synergistic action of both anticoagulants [4]. Contamination with heparins may occur in patients requiring CVC connection; for example, those with renal failure, cancer, or malnutrition [5,6]. Although concomitant administration of heparin and DOAC is rare in clinical practice, in some situations (e.g., patients on DOAC treatment who receive LMWH before/after surgery or during hemodialysis), LMWHs may remain in the blood and disturb the precise measurement of DOACs' activity [4,[7][8][9][10].…”
Section: Introductionmentioning
confidence: 99%