Hemolysis risk after packed red blood cells transfusion with infusion pumps

Wilson, Ana Maria Miranda Martins; Peterlini, Maria Angélica Sorgini

doi:10.1590/1518-8345.2625.3053

Cited by 12 publications

(19 citation statements)

References 21 publications

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“…3,18 Potassium concentrations are another widely used biomarker of RBC damage, but their use is not recommended when aged pRBCs are tested, as in our study. 6…”

Section: Discussionmentioning

confidence: 99%

“…Haemolysis caused by the use of PIPs has been described with both human and canine pRBCs. 1,3,5,6 The degree of haemolysis depends on factors such as infusion rate, blood haematocrit, preservative solution and administration catheter diameter. 3,4 Increased levels of haemolysis have also been observed when very low or high rates are used, and the storage time of pRBCs may also have a major effect on pump-induced haemolysis.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative assessment of infusion pump-mediated haemolysis in feline packed red blood cell transfusions

Blasi-Brugué

Sánchez

Ferreira

et al. 2021

Journal of Feline Medicine and Surgery

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Objectives Haemolysis caused by the use of peristaltic infusion pumps (PIPs) has been described in human and canine packed red blood cells (pRBCs). The aim of this study was to evaluate the effects of two different linear PIPs on the haemolysis of feline pRBC units stored for a long time. Methods Feline pRBC units stored with adenine, dextrose, mannitol and sodium chloride (SAGM) were manufactured. After 35–42 days of storage at 2–4°C, a line administration system with a 180 µm filter was attached to every pRBC bag, the system was drained by gravity alone (8 drops/min) and a 1.3 ml sample was collected (G). A NIKI V4 pump was then used at a flow rate of 25 ml/h, the flow was stopped when the infusion system was filled with blood coming from the infusion pump and another 1.3 ml sample was collected (NK). Finally, an Infusomat FmS pump was evaluated, collecting another 1.3 ml sample (IM). Packed cell volume (PCV) was measured in all samples by microhaematocrit centrifugation, total haemoglobin (HGB) was measured using a specific haemoglobin analyser and, after centrifugation, free HGB was determined by spectrophotometry. The percentage of haemolysis was calculated. Friedman’s test was used to compare the samples. Results Fifteen feline pRBC units were evaluated. The average degree of haemolysis for sample G (gravity-assisted) was 1.12%. Comparison of the degree of gravity-assisted haemolysis with haemolysis in PIP NK (1.13%) and IM (1.14%) samples revealed no significant differences, with differences of only 0.01% and 0.02%, respectively. Conclusions and relevance The results of this study demonstrate that the use of two common PIPs in veterinary hospitals does not produce levels of haemolysis that are significantly different than that caused by gravity alone during transfusion of feline pRBCs at a rate of 25 ml/h.

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“…3,18 Potassium concentrations are another widely used biomarker of RBC damage, but their use is not recommended when aged pRBCs are tested, as in our study. 6…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of infusion pump-mediated haemolysis in feline packed red blood cell transfusions

Blasi-Brugué

Sánchez

Ferreira

et al. 2021

Journal of Feline Medicine and Surgery

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“…The degree of haemolysis is 11 ± 6 times lower for blood pumped by the Qpump versus the traditional peristaltic pump. PFH values greater than 20 mg/dL are indicative of significant haemolysis 29 , and previous reports on packed red blood cells transfusion using infusion pumps showed 2-3 orders of magnitude higher PFH values 26,27 , which demonstrates that magnetic pumping is a promising way to achieve gentle transportation of blood. This method could be applied to other fragile entities such as antibodies or stem cells.…”

mentioning

confidence: 83%

“…It is known that blood pumping results in haemolysis, shear-induced rupture of red blood cells that releases haemoglobin. [22][23][24][25][26][27] High concentrations of free haemoglobin are cytotoxic, and have been associated…”

mentioning

confidence: 99%

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Liquid Flow and Control Without Solid Walls

Dunne¹,

Adachi²,

Sorrenti³

et al. 2019

Preprint

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<div>Solid walls become increasingly important when miniaturizing fluidic circuitry. They limit flow-rates achievable for a given pressure drop, and are plagued by fouling. Approaches to reduce the wall interactions include hydrophobic coatings, liquid-infused porous surfaces, nanoparticle surfactant jamming, changing the surface electronic structure, electrowetting, surface tension pinning, and atomically flat channels. A better solution may be to avoid the solid walls altogether. Droplet microfluidics or sheath flow achieves this, but require continuous flow of both the liquid transported and the outer carrier liquid. Here we demonstrate a new approach, where wall-less aqueous liquid channels are surrounded by an immiscible magnetic liquid, both being stabilised by a quadrupolar magnetic field. This creates self-healing, uncloggable, anti-fouling, and near-frictionless liquid-in-liquid fluidic channels with millimetre effective slip lengths. Pumping is achieved by moving permanent magnets that have no physical contact with the liquid channel. We show that this magnetostaltic pumping method can be used to transport whole human blood with very little damage due to shear forces; haemolysis is reduced by an order of magnitude compared to traditional peristaltic pumping. Our liquid-in-liquid approach provides new avenues to transport delicate liquids, particularly when scaling channels down to the micron scale with no need for high pressures, while retaining basic microfluidic circuitry functionalities.</div><div><br></div>

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Liquid flow and control without solid walls

Dunne

Adachi

Dev

et al. 2020

Nature

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Solid walls become increasingly important when miniaturizing fluidic circuitry to the micron scale or smaller. 1 They limit achievable flow-rates due to friction and high pressure drop, and are plagued by fouling 2 . Approaches to reduce the wall interactions have been explored using hydrophobic coatings 3,4 , liquid-infused porous surfaces [4][5][6] , nanoparticle surfactant jamming 7 , changing the surface electronic structure 8 , electrowetting 9,10 , surface tension pinning 11,12 , and atomically flat channels 13 . An interesting idea is to avoid the solid walls altogether. Droplet microfluidics achieves this, but requires continuous flow of both the liquid transported inside the droplets and the outer carrier liquid 14 . We demonstrate a new approach, where wall-less aqueous liquid channels are stabilised by a quadrupolar magnetic field that acts on a surrounding immiscible magnetic liquid. This creates self-healing, uncloggable, and near-frictionless liquidin-liquid microfluidic channels that can be deformed and even closed in real time without ever touching a solid wall. Basic fluidic operations including valving, mixing, and 'magnetostaltic' pumping can be achieved by moving permanent magnets having no physical contact with the channel. This wall-less approach is compatible with conventional microfluidics, while opening unique prospects for implementing nanofluidics without excessively high pressures.Magnetic forces have been used to avoid contact with the walls of a device by levitation of particles or live cells in suspension 15 , and a first attempt to make wall-less microfluidic channels resulted in continuous 'magnetic antitubes' of water surrounded by an aqueous paramagnetic salt solution 16 using

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Hemolysis risk after packed red blood cells transfusion with infusion pumps

Cited by 12 publications

References 21 publications

Quantitative assessment of infusion pump-mediated haemolysis in feline packed red blood cell transfusions

Quantitative assessment of infusion pump-mediated haemolysis in feline packed red blood cell transfusions

Liquid Flow and Control Without Solid Walls

Liquid flow and control without solid walls

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