2015
DOI: 10.1590/1516-635x1703293-300
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Abstract: This study aimed at examining the effect of overfeeding on the activity of the mTOR pathway in the liver and muscle tissues of Gang geese. Eighty healthy male Gang geese were reared under the same feeding conditions, and were divided at 14 weeks of age into a control group and an overfed group. All birds were slaughtered after three weeks of over feeding. Gene expression and protein content of several genes involved in the mTOR pathway were evaluated. The results showed that the gene expression of mTOR, raptor… Show more

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Cited by 4 publications
(3 citation statements)
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References 30 publications
(41 reference statements)
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“…It was reported that glucose and insulin caused similar acute signalling in mouse islets, but chronic signalling differed markedly, with mTOR and ERK activation by glucose and AKT activation by insulin (Stamateris et al., ). In our current study, it is found that insulin could stimulate the cell growth by activating the PI3K‐Akt‐mTOR signal pathway (Han et al., ,b). However, it is not clear whether the PI3K‐Akt‐mTOR signal pathway plays a role in glucose‐induced liver cell proliferation, a characteristic in hepatic steatosis.…”
Section: Discussionsupporting
confidence: 54%
See 1 more Smart Citation
“…It was reported that glucose and insulin caused similar acute signalling in mouse islets, but chronic signalling differed markedly, with mTOR and ERK activation by glucose and AKT activation by insulin (Stamateris et al., ). In our current study, it is found that insulin could stimulate the cell growth by activating the PI3K‐Akt‐mTOR signal pathway (Han et al., ,b). However, it is not clear whether the PI3K‐Akt‐mTOR signal pathway plays a role in glucose‐induced liver cell proliferation, a characteristic in hepatic steatosis.…”
Section: Discussionsupporting
confidence: 54%
“…The carbohydrate is mostly digested and absorbed in the small intestine in the form of glucose. In our previous study, accompanied by the rapid growth of liver, overfeeding induced the change of blood glucose level (Han et al., ); meanwhile, PI3K‐Akt‐mTOR signal pathway was also activated (Han et al., ,b), and we speculate that PI3K‐Akt‐mTOR pathway may mediate hepatocyte proliferation induced by glucose, subsequently increase cell growth. Therefore, in this study, goose primary hepatocytes were treated with glucose and/or inhibitors of the PI3K‐Akt‐mTOR pathway to detect the change of factors involved in cell proliferation, to ascertain the role of the PI3K‐Akt‐mTOR pathway in glucose‐induced cell growth.…”
Section: Introductionmentioning
confidence: 60%
“…Unlike human fatty liver, waterfowl liver can exhibit nonpathological hepatic steatosis, with the functional integrity of hepatocytes remaining intact. In our previous study, overfeeding was accompanied by lipid deposition in the liver, a change in blood glucose concentration [10] and activation of the PI3K-Akt-mTOR signaling pathway [11]. We speculated that the PI3K-Akt-mTOR pathway mediates glucose-induced lipid deposition.…”
Section: Introductionmentioning
confidence: 92%