Treating nightmares in PTSD with doxazosin: a report of three cases

Calegaro, Vítor Crestani; Mosele, Pedro Henrique Canova; Souza, Isabela Duarte e; Silva, Emanuelly Martins da; Trindade, Julia Pinto

doi:10.1590/1516-4446-2018-0292

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Nightmares are highly deleterious in PTSD, reducing the quality of life (El-Solh, 2018). Furthermore, treatments targeted to nightmares significantly improve the overall quality of life (Calegaro et al, 2019) Therefore, we investigated the characteristics of awakenings from sleep in our social defeat model by analyzing motor activation accompanying their spontaneous awakenings from sleep. Actively coping rats did not have as many exaggerated arousals from REM sleep as passively coping or control rats and this was apparent 2 weeks after defeats ended.…”

Section: Discussionmentioning

confidence: 99%

Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats

Grafe

O’Mara

Branch

et al. 2020

Front. Syst. Neurosci.

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Exposure to severe stress has immediate and prolonged neuropsychiatric consequences and increases the risk of developing Posttraumatic Stress Disorder (PTSD). Importantly, PTSD develops in only a subset of individuals after exposure to a traumatic event, with the understanding of this selective vulnerability being very limited. Individuals who go on to develop PTSD after a traumatic experience typically demonstrate sleep disturbances including persistent insomnia and recurrent trauma-related nightmares. We previously established a repeated social defeat paradigm in which rats segregate into either passively or actively coping subpopulations, and we found that this distinction correlates with measures of vulnerability or resilience to stress. In this study, we examined differences between these two behavioral phenotypes in sleep changes resulting from repeated social defeat stress. Our data indicate that, compared to control and actively coping rats, passively coping rats have less slow-wave sleep (SWS) for at least 2 weeks after the end of a series of exposures to social defeat. Furthermore, resilient rats show less exaggerated motor activation at awakenings from rapid eye movement (REM) sleep and less fragmentation of REM sleep compared to control and passively coping rats. Together, these data associate a passive coping strategy in response to repeated social defeat stress with persisting sleep disturbances. Conversely, an active coping strategy may be associated with resilience to sleep disturbances. These findings may have both prognostic and therapeutic applications to stress-associated neuropsychiatric disorders, including PTSD.

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Section: Discussionmentioning

confidence: 99%

Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats

Grafe

O’Mara

Branch

et al. 2020

Front. Syst. Neurosci.

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Pharmacological Management of Nightmares Associated with Posttraumatic Stress Disorder

et al. 2022

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Neurobiology of Dream Activity and Effects of Stimulants on Dream

Murillo-Rodrı́guez

Coronado-Álvarez

López-Muciño

et al. 2022

CTMC

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The sleep-wake cycle is the result of the activity of a multiple neurobiological network interaction. Dreaming feature is one interesting sleep phenomena that represents sensorial components, mostly visual perceptions, accompanied with intense emotions. Further complexity has been added to the topic of the neurobiological mechanism of dreams generation by the current data that suggests the influence of drugs on dream generation. Here, we discuss the review on some of the neurobiological mechanism of the regulation of dream activity, with special emphasis on the effects of stimulants on dreaming.

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Treating nightmares in PTSD with doxazosin: a report of three cases

Cited by 3 publications

References 5 publications

Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats

Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats

Pharmacological Management of Nightmares Associated with Posttraumatic Stress Disorder

Neurobiology of Dream Activity and Effects of Stimulants on Dream

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