Gender differences of cannabis smoking on serum leptin levels: population-based study

Moreira, Fernanda Pedrotti; Wiener, Carolina David; Oliveira, Jacqueline Flores de; Souza, Luciano Dias de Mattos; Silva, Ricardo Azevedo da; Portela, Luis Valmor; Lara, Diogo R.; Jansen, Karen; Oses, Jean Pierre

doi:10.1590/1516-4446-2017-2231

Cited by 6 publications

(2 citation statements)

References 14 publications

(23 reference statements)

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“…One possible explanation of increased leptin is that the level of endogenous cannabinoids is inversely associated with leptin’s plasma concentration. , However, the high levels of exogenous cannabinoid stimulation might feedback negatively on endogenous cannabinoid production, leading to increases in leptin . On the contrary, in healthy adults instead of HIV-positive patients, consuming cannabis showed no significant or significant down-regulation effects on plasma leptin. , In parallel, the plasma concentrations of anorexic hormone GLP-1 in healthy volunteers were lower under cannabis consumption than in placebo condition, while the spike in blood insulin concentrations observed under the placebo condition due to food intake was blunted by cannabis administration . Although the acute consumption of recreational cannabis exhibited an overall orexigenic effect due to their dominant content of THC, some other cannabinoids such as THCV, CBD, and CBN may show an anorexigenic effect in the form of pure standard, as tentatively explained by their actions on CB 1 (antagonism)/CB 2 (agonism) receptors or TRPV channels (activation) .…”

Section: Interaction Between Cannabinoids and Gastrointestinal Systemmentioning

confidence: 98%

Cannabis and Cannabis Edibles: A Review

Peng

Shahidi

2021

J. Agric. Food Chem.

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Cannabis is an excellent natural source of fiber and various bioactive cannabinoids. So far, at least 120 cannabinoids have been identified, and more novel cannabinoids are gradually being unveiled by detailed cannabis studies. However, cannabinoids in both natural and isolated forms are especially vulnerable to oxygen, heat, and light. Therefore, a diversity of cannabinoids is associated with their chemical instability to a large extent. The research status of structural conversion of cannabinoids is introduced. On the other hand, the use of drug-type cannabis and the phytocannabinoids thereof has been rapidly popularized and plays an indispensable role in both medical therapy and daily recreation. The recent legalization of edible cannabis further extends its application into the food industry. The varieties of legal edible cannabis products in the current commercial market are relatively monotonous due to rigorous restrictions under the framework of Cannabis Regulations and infancy of novel developments. Meanwhile, patents/studies related to the safety and quality assurance systems of cannabis edibles are still rare and need to be developed. Furthermore, along with cannabinoids, many phytochemicals such as flavonoids, lignans, terpenoids, and polysaccharides exist in the cannabis matrix, and these may exhibit prebiotic/probiotic properties and improve the composition of the gut microbiome. During metabolism and excretion, the bioactive phytochemicals of cannabis, mostly the cannabinoids, may be structurally modified during enterohepatic detoxification and gut fermentation. However, the potential adverse effects of both acute and chronic exposure to cannabinoids and their vulnerable groups have been clearly recognized. Therefore, a comprehensive understanding of the chemistry, metabolism, toxicity, commercialization, and regulations regarding cannabinoid edibles is reviewed and updated in this contribution.

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Section: Interaction Between Cannabinoids and Gastrointestinal Systemmentioning

confidence: 98%

Cannabis and Cannabis Edibles: A Review

Peng

Shahidi

2021

J. Agric. Food Chem.

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“…Hyperphagia caused by CS occurs due to its action on hypothalamic cannabinoid receptors and on endocrine and digestive mechanisms, for example, the reduction of leptin release [45,56,57]. The centers that regulate eating behavior are located in hypothalamus, and leptin is a hormone produced in the adipose tissue that acts in this area of the brain and reduces appetite [58].…”

Section: Cannabis Sativa and Its Immediate Effectsmentioning

confidence: 99%

Cannabis sativa – A matter of physical, mental, and social health

Cortez¹,

Cortez-Calderini²,

Silva³

2024

Eastern J Med Sci

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Several studies show that chronic marijuana use opens doors to several disorders, especially neuropsychiatric disorders. Others consider cannabinoids to be promising in therapeutic practice. Here, we present a literature review, based on selected publications on the Medline and Scielo databases, on health and cannabis use. This review aims to assist health professionals and students in understanding the growing number of marijuana users who look for help in outpatient clinics and offices. Therefore, there is an increase in the frequency of hospital admissions for psychotic disorders in clinics and specific treatment institutions. Research over the past 35 years has shown that marijuana use promotes only momentary anxiolysis. This drug alone or in combination with cigarette, when consumed for a long term, can deteriorate the user’s intellectual capacity, academic performance, and professional achievements and finally results in social isolation. The current situation demonstrates that cannabis usage is a public health issue that needs to be addressed in health policy because the majority of users get sick and lose their ability to work.

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