Childhood emotional and behavior problems and their associations with cesarean delivery

Rutayisire, Erigene; Wu, Xiaoyan; Huang, Kun; Tao, Shuman; Chen, Yunxiao; Tao, Fangbiao

doi:10.1590/1516-4446-2016-2152

Cited by 17 publications

(29 citation statements)

References 38 publications

(48 reference statements)

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“…A study of approximately 11 000 Irish children found CS delivery to be associated with a delay in personal social skills at 9 months (odds ratio of 1.24 214 ). In a study of early childhood in China, any CS delivery was associated with abnormal pro‐social behaviour (odds ratio of 1.27) and emergency CS was associated with peer problems (odds ratio of 1.25 231 ). However, such effects were not seen in a British cohort using a slightly less sensitive checklist 232 .…”

Section: Known Associations Of Caesarean Delivery With Developmental mentioning

confidence: 99%

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Birth signalling hormones and the developmental consequences of caesarean delivery

Kenkel

2020

J Neuroendocrinology

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Rates of delivery by caesarean section (CS) are increasing around the globe and, although several epidemiological associations have already been observed between CS and health outcomes in later life, more are sure to be discovered as this practice continues to gain popularity. The components of vaginal delivery that protect offspring from the negative consequences of CS delivery in later life are currently unknown, although much attention to date has focused on differences in microbial colonisation. Here, we present the case that differing hormonal experiences at birth may also contribute to the neurodevelopmental consequences of CS delivery. Levels of each of the ‘birth signalling hormones’ (oxytocin, arginine vasopressin, epinephrine, norepinephrine and the glucocorticoids) are lower following CS compared to vaginal delivery, and there is substantial evidence for each that manipulations in early life results in long‐term neurodevelopmental consequences. We draw from the research traditions of neuroendocrinology and developmental psychobiology to suggest that the perinatal period is a sensitive period, during which hormones achieve organisational effects. Furthermore, there is much to be learned from research on developmental programming by early‐life stress that may inform research on CS, as a result of shared neuroendocrine mechanisms at work. We compare and contrast the effects of early‐life stress with those of CS delivery and propose new avenues of research based on the links between the two bodies of literature. The research conducted to date suggests that the differences in hormone signalling seen in CS neonates may produce long‐term neurodevelopmental consequences.

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Section: Known Associations Of Caesarean Delivery With Developmental mentioning

confidence: 99%

“…230 214 ). In a study of early childhood in China, any CS delivery was associated with abnormal pro-social behaviour (odds ratio of 1.27) and emergency CS was associated with peer problems (odds ratio of 1.25 231 ). However, such effects were not seen in a British cohort using a slightly less sensitive checklist.…”

Section: Emotion and Mental Healthmentioning

confidence: 99%

Birth signalling hormones and the developmental consequences of caesarean delivery

Kenkel

2020

J Neuroendocrinology

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“…The Microbiota-Gut-Brain-Axis concept is gaining relevance and recent scientific evidences suggest an important role of the gut microbiota in brain processes. In this way, some works have linked the effect of CS with the incidence of neuropsychiatric disorders [36] or risk of behavioural problems [37]. More investigations are needed to confirm the relationship between CS, gut microbiota and brain function, in order to design nutritional strategies helping at the establishment of a correct microbiota-gut-brain axis connection in early life.…”

Section: Perspectives and Future Trends On The Research About The Relmentioning

confidence: 99%

C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health

et al. 2018

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Background: The human gut microbiota is assembled during infancy with an increase in diversity and stability. The correct colonization and the establishment of this microbiome are linked to the early and future health status of the individual. It is known that caesarean delivery alters this optimal microbial foundation. C-section (CS) is a common obstetrician surgery; however, it is not without risk for the mother/infant dyad. The World Health Organization recommends not exceeding 10–15% of the total deliveries; nevertheless, this rate has been increasing rapidly worldwide in the last decades. Summary: This review discloses the clinical parameters for correct CS recommendation. Moreover, the major microbial changes in the infant gut microbiome acquisition as a consequence of delivery mode and medical practices surrounding it, as well as, the early and long-lasting effects for both mother and babies are discussed. In addition, some strategies for the gut microbiota restoration are analysed. The aim of this review is to show the need for the development of strategies for minimizing or limiting the impact of caesarean on the microbiome development, favouring future health.

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“…; Rutayisire et al . ). The concept stemmed from an interesting series of animal studies on CS (± anoxia exposure post‐birth) (Boksa & El‐Khodor, ) and has promoted an ongoing debate as to whether childhood emotional and behavioural problems may be increased in children delivered by CS.…”

Section: Introductionmentioning

confidence: 97%

Parturition and the perinatal period: can mode of delivery impact on the future health of the neonate?

Tribe

Taylor

Kelly

et al. 2018

The Journal of Physiology

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Caesarean section and instrumental delivery rates are increasing in many parts of the world for a range of cultural and medical reasons, with limited consideration as to how 'mode of delivery' may impact on childhood and long-term health. However, babies born particularly by pre-labour caesarean section appear to have a subtly different physiology from those born by normal vaginal delivery, with both acute and chronic complications such as respiratory and cardio-metabolic morbidities being apparent. It has been hypothesized that inherent mechanisms within the process of labour and vaginal delivery, far from being a passive mechanical process by which the fetus and placenta are expelled from the birth canal, may trigger certain protective developmental processes permissive for normal immunological and physiological development of the fetus postnatally. Traditionally the primary candidate mechanism has been the hormonal surges or stress response associated with labour and vaginal delivery, but there is increasing awareness that transfer of the maternal microbiome to the infant during parturition. Transgenerational transmission of disease traits through epigenetics are also likely to be important. Interventions such as probiotics, neonatal gut seeding and different approaches to clinical care have potential to influence parturition physiology and improve outcomes for infants.

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Childhood emotional and behavior problems and their associations with cesarean delivery

Cited by 17 publications

References 38 publications

Birth signalling hormones and the developmental consequences of caesarean delivery

Birth signalling hormones and the developmental consequences of caesarean delivery

C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health

Parturition and the perinatal period: can mode of delivery impact on the future health of the neonate?

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