2016
DOI: 10.1590/1516-4446-2015-1777
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Abstract: Autism spectrum disorders (ASDs) are characterized by deficits in the individual's ability to socialize, communicate, and use the imagination, in addition to stereotyped behaviors. These disorders have a heterogenous phenotype, both in relation to symptoms and regarding severity. Organic problems related to the gastrointestinal tract are often associated with ASD, including dysbiosis, inflammatory bowel disease, exocrine pancreatic insufficiency, celiac disease, indigestion, malabsorption, food intolerance, an… Show more

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Cited by 39 publications
(32 citation statements)
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“…The microbial composition of MIA mice showed increased levels of Porphyromonadaceae, Prevotellaceae and decreased levels of Ruminococcaceae, Erysipelotrichaceae and Alcaligenaceae [16]. Bacteroides, Bifidobacterium and Lactobacillus species create an anti-inflammatory milieu, whereas Clostridium species stimulate a pro-inflammatory milieu [70]. Cytokines produced by microbiota affected the oligodendrocytes.…”
Section: Developmemt and Disruptions Of Microbial Colonisation Potentmentioning
confidence: 99%
“…The microbial composition of MIA mice showed increased levels of Porphyromonadaceae, Prevotellaceae and decreased levels of Ruminococcaceae, Erysipelotrichaceae and Alcaligenaceae [16]. Bacteroides, Bifidobacterium and Lactobacillus species create an anti-inflammatory milieu, whereas Clostridium species stimulate a pro-inflammatory milieu [70]. Cytokines produced by microbiota affected the oligodendrocytes.…”
Section: Developmemt and Disruptions Of Microbial Colonisation Potentmentioning
confidence: 99%
“…For instance, elevated levels of casomorphins and gluten exorphins were observed in the urine samples of autism patients (Bojović et al, ), suggesting an increased gut permeability and a compromised degradation of these peptides. Indeed, autism patients are often faced with various gastrointestinal disorders, such as celiac disease, food allergies, and malabsorption (Lázaro, Pondé, & Rodrigues, ). Moreover, the polymorphisms on DPPIV gene and opioid excess in blood are considered to be associated with pathogenesis of autism (Cieslinska et al, ).…”
Section: Functions Of Food‐derived Opioid Peptides In Pathological Comentioning
confidence: 99%
“…Otizmli bireylerde, bozulmuş epitel bariyer fonksiyonu ve glutene karşı oluşan allerjilerden dolayı zonulin molekülü otizm patogenezinde önemli bir rol oynayabilmektedir. 9 …”
Section: Sizdiran Barsak Hi̇potezi̇unclassified