Animal models of alcohol and drug dependence

Planeta, Cleópatra da Silva

doi:10.1590/1516-4446-2013-1149

Cited by 27 publications

(19 citation statements)

References 72 publications

(93 reference statements)

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“…In order to investigate morphine preference in animals, two‐bottle‐choice paradigm (Planeta, 2013) was used in the study. It is a non‐operant self‐administration method limited to the oral route of administration.…”

Section: Methodsmentioning

confidence: 99%

Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring

Vousooghi

Sadat‐Shirazi

Safavi

et al. 2018

Intl J of Devlp Neuroscience

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Addiction to drugs, including opioids is the result of an interplay between environmental and genetic factors. It has been shown that the progeny of addict people is at higher risk for drug addiction. However, the mechanisms of such trans-generational effects of drugs are not so clear. Here we have evaluated the effects of parental morphine consumption on anxiety, morphine preference, and mRNA expression of dopamine receptors in F1 and F2 male offspring. Morphine was chronically administered to adult male and female Wistar rats followed by 14-day abstinence before mating. Morphine preference and anxiety-like behavior in the offspring were measured by two-bottle-choice paradigm and elevated-plus maze, respectively. Real-time PCR was used to measure the mRNA expression level of dopamine receptors in the striatum, nucleus accumbens, prefrontal cortex, and hippocampus of F1 animals. The results indicated that F1 but not the F2 male progeny of morphine-exposed parents had a greater preference for morphine, and more anxiety-like behavior compared to the offspring of saline-treated parents. In F1 male progeny of morphine-treated parents, D1 and D5 dopamine receptors were significantly increased in the prefrontal cortex and nucleus accumbens. D5 and D2 receptors were decreased in the hippocampus. D4 dopamine receptor was augmented in striatum and hippocampus and decreased in the prefrontal cortex. Adulthood exposure to chronic morphine in male and female rats before conception leads to higher morphine preference and increased anxiety in F1 but not F2 male progeny. Alterations of dopamine receptor expression in the reward system may be one mechanism responsible for observed changes in F1 offspring.

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Section: Methodsmentioning

confidence: 99%

Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring

Vousooghi

Sadat‐Shirazi

Safavi

et al. 2018

Intl J of Devlp Neuroscience

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“…Xue et al, 2012;Planeta, 2013). In rat models of drug abuse, tolerance, dependence and withdrawal are essential paradigms of the addictive properties of a given substance.…”

Section: A Critical Review Of Rodent Models Of "Food Addiction"mentioning

confidence: 99%

“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior

Hebebrand

Albayrak

Adan

et al. 2014

Neuroscience & Biobehavioral Reviews

424

247

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"Food addiction" has become a focus of interest for researchers attempting to explain certain processes and/or behaviors that may contribute to the development of obesity. Although the scientific discussion on "food addiction" is in its nascent stage, it has potentially important implications for treatment and prevention strategies. As such, it is important to critically reflect on the appropriateness of the term "food addiction", which combines the concepts of "substance-based" and behavioral addiction. The currently available evidence for a substance-based food addiction is poor, partly because systematic clinical and translational studies are still at an early stage. We do however view both animal and existing human data as consistent with the existence of addictive eating behavior. Accordingly, we stress that similar to other behaviors eating can become an addiction in thus predisposed individuals under specific environmental circumstances. Here, we introduce current diagnostic and neurobiological concepts of substance-related and non-substance-related addictive disorders, and highlight the similarities and dissimilarities between addiction and overeating. We conclude that "food addiction" is a misnomer because of the ambiguous connotation of a substance-related phenomenon. We instead propose the term "eating addiction" to underscore the behavioral addiction to eating; future research should attempt to define the diagnostic criteria for an eating addiction, for which DSM-5 now offers an umbrella via the introduction on Non-Substance-Related Disorders within the category Substance-Related and Addictive Disorders.

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“…The modus operandi for drug use in 41 animals is the self-administration paradigm (18,865 publications between 2009-42 2019 via PubMed), in which, animals perform a behavior to consume a drug or 43 saline. Numerous variations of drug self-administration exist to model addiction 44 related behavior, but our study predominately focuses on the classic (short-access) 45 cocaine self-administration paradigm, which is considered a valid model for 46 reinforcement learning and voluntary cocaine use 2,3 . These features seem important 47 for the development of substance abuse, but controversy remains pertaining to the 48 relationship between classic animal self-administration paradigms and human drug 49 addiction 4,5 .…”

Section: Introduction 37mentioning

confidence: 99%

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder

Huggett

Bubier

Chesler

et al. 2020

Preprint

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Animal models of drug use have been employed for over 100 years to facilitate the 10 identification of mechanisms governing human substance use and addiction. Most 11 cross-species research on drug use/addiction examines behavioral overlap, but 12 studies assessing neuro-molecular correspondence are lacking. Our study utilized 13 transcriptome-wide data from the hippocampus and ventral tegmental area 14 (VTA)/midbrain from a total of 35 human males with cocaine use disorder/controls 15 and 49 male C57BL/6J cocaine/saline administering/exposed mice. We 16hypothesized that individual genes (differential expression) and systems of co-17 expressed genes (gene networks) would demonstrate appreciable overlap across 18 mouse cocaine self-administration and human cocaine use disorder. We found 19modest, but significant associations between differentially expressed genes 20 associated with cocaine self-administration (short access) and cocaine use disorder 21 within meso-limbic circuitry, but non-robust associations with mouse models of 22 acute cocaine exposure, (cocaine) context re-exposure and cocaine + context re-23 exposure. Investigating systems of co-expressed genes, we also found several 24 validated gene networks with weak to moderate conservation between 25 cocaine/saline self-administering mice and disordered cocaine users/controls. The 26 most conserved hippocampal and VTA gene networks demonstrated substantial 27 overlap (2,029 common genes) and included novel and previously implicated 28 targets of cocaine use/addiction. Lastly, we conducted expression-based phenome-29 wide association studies of the nine common hub genes across conserved gene 30 networks and found that they were associated with dopamine/serotonin function, 31cocaine self-administration and other relevant mouse traits. Overall, our study 32 identified and characterized homologous transcriptional effects between mouse 33 models of cocaine self-administration and human cocaine use disorder that may 34 serve as a benchmark for future research. 35 36

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Animal models of alcohol and drug dependence

Cited by 27 publications

References 72 publications

Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring

Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring

“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use Disorder

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