What anthropometric indicators are associated with insulin resistance? Cross-sectional study on children and adolescents with diagnosed human immunodeficiency virus

Alves, Carlos Alencar Souza; Martins, Priscila Custódio; Lima, Luiz Rodrigo Augustemak de; Silva, Diego Augusto Santos

doi:10.1590/1516-3180.2021.0303.27052021

Cited by 1 publication

(1 citation statement)

References 30 publications

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“…Insulin resistance as measured by homeostatic model assessment of insulin resistance (HOMA-IR) has been well reported in PHIV [4][5][6][7][8][9][10]; however, most of the data have come from the United States of America (USA). Few cross-sectional studies have reported on insulin resistance in PHIV on ART in SSA [11][12][13][14][15], and to our knowledge, only one longitudinal study has been conducted in SSA with younger PHIV children virally suppressed on ART [16].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with insulin resistance in a longitudinal study of Ugandan youth with and without HIV

Dirajlal-Fargo,

Strah,

Ailstock

et al. 2023

Aids

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Prospective investigations from sub-Saharan Africa on metabolic complications in youth with perinatally acquired HIV (PHIV) are lacking. We investigated the changes in insulin resistance in Ugandan PHIV on ART and uninfected controls and their relationship with inflammation, HIV and cardiovascular disease (CVD) risk factors. Participants 10–18 years of age were included in a prospective study performed in Kampala, Uganda. We compared baseline and changes in insulin resistance (by HOMA-IR) and in markers of inflammation at baseline and 96 weeks. PHIVs were on ART with HIV-1 RNA level ≤400 c/mL. Generalized Estimating Equation models were used to assess associations between HOMA-IR, and demographic as well as inflammatory markers. Of the 197 participants recruited at baseline (101 PHIV, 96 HIV-), 168 (89 PHIV, 79 HIV-) had measurements at 96 weeks. At baseline, median (Q1, Q3) age was 13 years (11,15), 53.5% were females, median CD4+ cell counts were 988 cells/μL (631, 1310). At baseline, HOMA-IR was significantly higher in PHIV compared to controls (p = 0.03). HOMA-IR did not significantly change by week 96 in either group, and at 96 weeks, was similar between groups (p = 0.15). HOMA-IR was not associated with any inflammatory markers, or any specific ART. In longitudinal analysis, age and Tanner stage remained associated with higher HOMA-IR throughout the study period, after adjusting for HIV status. In this longitudinal cohort of virally suppressed PHIV in Uganda, PHIV have decreased insulin sensitivity compared to controls, however this difference does not persist through adolescence. ART and immune activation do not appear to affect glucose homeostasis in this population.

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Section: Introductionmentioning

confidence: 99%

Factors associated with insulin resistance in a longitudinal study of Ugandan youth with and without HIV

Dirajlal-Fargo,

Strah,

Ailstock

et al. 2023

Aids

View full text Add to dashboard Cite

show abstract

What anthropometric indicators are associated with insulin resistance? Cross-sectional study on children and adolescents with diagnosed human immunodeficiency virus

Abstract: What anthropometric indicators are associated with insulin resistance? Cross-sectional study on children and adolescents with diagnosed human immunodeficiency virus | ORIGINAL ARTICLE

Cited by 1 publication

References 30 publications

Factors associated with insulin resistance in a longitudinal study of Ugandan youth with and without HIV

Factors associated with insulin resistance in a longitudinal study of Ugandan youth with and without HIV

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