Vitamin D supplementation for women during pregnancy

De-Regil, Luz María; Palacios, Cristina; Lombardo, L; Peña-Rosas, Juan Pablo

doi:10.1590/1516-3180.20161343t2

Cited by 48 publications

(49 citation statements)

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“…It is worth mentioning that confounding factors including diet, seasonality, maternal weight gain during pregnancy, and birth spacing were not significantly different between groups. In accord with our findings, other trials suggested that vitamin D supplementation during pregnancy resulted in improved birth outcomes (Chen et al, ; De‐Regil et al, ; Hollis & Wagner, ; Miliku et al, ; Sablok et al, ; Weernink et al, ; Zerofsky et al, ). It has been reported that maternal vitamin D status was positively and significantly associated with birth size (weight and length; Nandal et al, ; Perez‐Lopez et al, ; Rostami, Ramezani Tehrani, Simbar, Hosseinpanah, & Alavi Majd, ).…”

Section: Discussionsupporting

confidence: 92%

“…At 34 weeks of gestation, frequency of vitamin D sufficiency in the 2,000‐IU/d group was 1.8 times higher than in the 1,000‐IU/d group. This finding was similar to that of other trials that examined the effectiveness of the same doses of vitamin D supplementation (Cooper et al, ; De‐Regil, Palacios, Lombardo, & Pena‐Rosas, ; Grant et al, ; Hollis, Johnson, Hulsey, Ebeling, & Wagner, ; Roth et al, ; Sahoo, Katam, Das, Agarwal, & Bhatia, ; Zerofsky, Jacoby, Pedersen, & Stephensen, ). Pregnancy‐induced increased body fat mass and hemodilution may explain to some extent the increased vitamin D need of a pregnant woman.…”

Section: Discussionsupporting

confidence: 87%

“…The effect of vitamin D supplementation on the pregnancy outcomes including preeclampsia, gestational diabetes, and spontaneous abortion has not been confirmed by several RCTs (Asemi, Karamali, & Esmaillzadeh, ; Karamali, Asemi, Ahmadi‐Dastjerdi, & Esmaillzadeh, ; Perez‐Lopez et al, ; Roth et al, ). Nonetheless, there are few interventional studies with large sample size that support the positive effect of vitamin D supplementation during pregnancy on pregnancy outcomes (De‐Regil et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

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Hypovitaminosis D during pregnancy is suggested to have a link with complications in both mother and infant. We aimed to evaluate the efficacy of two doses of vitamin D3 supplementation during pregnancy on maternal and cord blood vitamin D status, inflammatory biomarkers, and maternal and neonatal outcomes. A total of 84 pregnant women (gestational age of <12 weeks) were randomly allocated to one of two groups: (a) 1,000‐IU/d vitamin D and (b) 2,000 IU/d. Biochemical assessments (25‐hydroxycalciferol (25(OH)D), hs‐CRP, and cell‐culture supernatant concentrations of IL‐1β, IL‐6, and TNF‐α) of mothers were performed at the beginning and 34 weeks of gestation. Assessments of infants at delivery comprised cord blood serum concentrations of 25(OH)D, hs‐CRP, IL‐1β, IL‐6, TNF‐α, birth sizes, and Apgar score. Circulating concentrations of 25(OH)D increased in both intervention groups with more increment in 2,000 IU/d than in 1,000 IU/d (46.7 ± 30.7 vs. 24.0 ± 21.07 nmol L−1, P = .001). Concentrations of TNF‐α decreased significantly in group 2,000 (−913.1 ± 1261.3 ng L−1, P = .01). The cord blood concentration of IL‐6 in group 2,000 IU/d, compared with 1,000 IU/d, was significantly lower (25.9 ± 32.0 vs. 4.6 ± 1.4 ng L−1, P = .03). The birth sizes including weight, length, and head circumference of the infants of group 2,000 IU/d were significantly higher than the infants' of group 1,000 IU/d. Supplementation with 2,000‐IU/d vitamin D3 is more effective than 1,000 IU/d in pregnant women in terms of increasing circulating 25(OH)D, ameliorating pro‐inflammatory markers notably TNF‐α in mother and IL‐6 in cord blood, and improving neonatal outcomes including the birth sizes.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Motamed

Nikooyeh

Kashanian

et al. 2019

Maternal & Child Nutrition

View full text Add to dashboard Cite

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“…It is important to note that we excluded trials that combined vitamin D and calcium supplementation: in their meta-analysis, De-Regil et al found that women who received vitamin D and calcium supplements together had an increased risk of PTB (RR, 1.57; 95%CI: 1.02-2.43). 40 Furthermore, studies with sample size >100, low risk of bias, and single-dose vitamin D supplementation all showed that vitamin D supplement could reduce the risk of PTB, but we could not draw a conclusion because the subgroups had only one or two RCTs, and the results may be misleading. Sensitivity analysis of RCT indicated that the Sablok et al 34 and Grant et al studies 37 could both significantly affect the results.…”

Section: Discussionmentioning

confidence: 86%

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Zhou

Tao

Huang

et al. 2017

J of Obstet and Gynaecol

106

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Aim: We performed a meta-analysis of randomized controlled trials (RCT) and observational studies to answer the two following questions: (i) whether low maternal circulating 25 hydroxyvitamin D (25-OHD) is associated with an increased risk of preterm birth (PTB) or spontaneous PTB (sPTB); and (ii) whether vitamin D supplementation alone during pregnancy can reduce the risk of PTB. Methods: Literature search was carried out using Pubmed, Web of Science and Embase databases up to June 2016. Pooled OR or relative risk (RR) with 95%CI were computed using fixed or random effects models depending on the size of heterogeneity. Subgroup analysis was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Egger's test and Begg's test. Results: Twenty-four articles (six RCT and 18 observational studies) were identified. Maternal circulating 25-OHD deficiency (pooled OR, 1.25; 95%CI: 1.13-1.38) rather than insufficiency (pooled OR, 1.09; 95%CI: 0.89-1.35) was associated with an increased risk of PTB, and vitamin D supplementation alone during pregnancy could reduce the risk of PTB (pooled RR, 0.57; 95%CI: 0.36-0.91). This was also the case for the sPTB subgroup (circulating 25-OHD <50 vs >50 nmol/L; pooled OR, 1.45; 95%CI: 1.20-1.75). Conclusions: Maternal circulating 25-OHD deficiency could increase PTB risk and vitamin D supplementation alone during pregnancy could reduce PTB risk. Extrapolation of the results, however, must be done with caution, and there is urgent need for larger, better-designed RCT to confirm this effect.

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“…The data from 6 trials of 1,687 ladies who got vitamin D supplements during pregnancy were less likely to be at risk of PTB than those got placebo therapy or routine prenatal care. De-Regil et al (2016) found that ladies who received vitamin D and calcium complements had an increase hazard of PTB [47]. In southern China, a study conducted by showed that daily consumption of 400 µg folic acid alone during the preconception period was linked with a reduction hazard of spontaneous PTB.…”

Section: Discussionmentioning

confidence: 99%

Maternal Lifestyle and Behavioral Factors Affect Risk of Spontaneous Preterm Birth

Sayed¹

2019

AJNS

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Aim of study: The study was carried out to evaluate maternal lifestyle and behavioral factors affecting the risk of spontaneous PTB. Methods: A descriptive study design was done in the postnatal ward of the Obstetrics Department at Zagazig University Hospital, Zagazig City, Al Sharkia Governorate. The sample of 200 women was assigned to two groups selected through the purposive sampling method from January to September 2017. The questionnaire was designed to collect background data of women. Also, lifestyle and behavioral features of women during pregnancy period. Results: The results of the current study showed that, there were no statistically significant differences between the two groups according to their socio-demographic characteristics group (P > 0.05). However, there was a significant relation between spontaneous preterm birth and inadequate antenatal care, short inter-pregnancy interval, and lifestyle factors (P<0.001). Moreover, serious life events and vital exhaustion during their pregnancy were significant risk factors for spontaneous preterm birth. Conclusion: There is a statistically significant relationship between inter-pregnancy intervals (less than 12 months) and increased risk of spontaneous PTB. As well as, stresses of heavy and night working associated with the risk of PTB. Serious lifestyle events for pregnant women contribute to a significant increase in the risk of PTB, where Short sleep duration or prolonged, and vital exhaustion were highly associated with an increased risk of spontaneous PTB.

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Vitamin D supplementation for women during pregnancy

Cited by 48 publications

References 1 publication

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Efficacy of two different doses of oral vitamin D supplementation on inflammatory biomarkers and maternal and neonatal outcomes

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Maternal Lifestyle and Behavioral Factors Affect Risk of Spontaneous Preterm Birth

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