Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
H.B. Costa-Filho,
T.M.A.L. Sales,
S.M. Paula
et al.
Abstract:The role of cyclooxygenase (COXs) isoforms in maintaining colonic mucosal integrity is not fully understood. This study aimed to evaluate the role of COX-1 and -2 on colonic mucosal integrity in an experimental colitis model. Colitis was induced in Wistar rats by intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (20 mg + 50% ethanol). The control group (sham group) received saline only. After 7, 14, or 28 days, colonic samples were removed, and macroscopic lesion scores, wet weight, myeloperoxi… Show more
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