Aging and low-intensity exercise change oxidative biomarkers in brain regions and radiographic measures of femur of Wistar rats

Silveira, Elza Maria Santos da; Santos, Marí Castro; Silva, T C B da; Silva, F B O; Machado, Caroline; Elias, Lucila Leico Kagohara; Kolberg, Angela; Kroth, Adarly; Partata, Wania Aparecida

doi:10.1590/1414-431x20209237

Cited by 6 publications

(2 citation statements)

References 35 publications

(64 reference statements)

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“…Existen distintos modelos que buscar emular los efectos de la osteoporosis en el hueso, tales como, utilización de animales envejecidos, baja ingesta de calcio en la dieta, inducción por déficit de estrógeno mediante ovariectomía, entre otros. (Silveira et al, 2020, Tang et al, 2019 El desarrollo de modelos por OVX ha cobrado relevancia, debido a que permite aislar la variable envejecimiento al momento de realizar el estudio. El modelo por OVX se sustenta en la base de que la deficiencia de estrógeno, el cual produciría un aumento en la reabsorción por parte de los osteoclastos y una respuesta de formación ósea deficiente.…”

Section: Discussionunclassified

Análisis Descriptivo de un Modelo de Osteoporosis Inducida en Ratas (Rattus norvegicus)

2021

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Section: Discussionunclassified

Análisis Descriptivo de un Modelo de Osteoporosis Inducida en Ratas (Rattus norvegicus)

2021

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“…It initiates iron autophagy, degrading ferritin and releasing large amounts of iron, raising intracytoplasmic Fe 2+ , and activating expression of mitochondrial membrane permeability protein and transporting Fe 2+ into mitochondria, resulting in mitochondrial lipid peroxidation and death. [77][78][79] Knockdown of NCOA4 reduced iron autophagy and made cells more resistant to lipid peroxidation and ferroptosis. 80 Then, the application of iron chelators, which reduce iron ion concentrations, suppressed ferroptosis and improved survival of septic patients, suggesting that the development of ferroptosis requires abnormal iron metabolism as a critical step.…”

Section: Iron Overloaded In Sepsismentioning

confidence: 99%

The Emerging Role of Ferroptosis in Sepsis, Opportunity or Challenge?

Huang,

Ding,

Fang

et al. 2023

IDR

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Sepsis is a syndrome in multi-organ dysfunction triggered by a deleterious immunological reaction of the body to a condition caused by infection, surgery, or trauma. Currently, sepsis is thought to be primarily associated with abnormal immune responses resulting in organ microcirculatory disturbances, cellular mitochondrial dysfunction, and induced cell death, although the exact pathogenesis of sepsis is still inconclusive. In recent years, the role of abnormal metabolism of trace nutrients in the pathogenesis of sepsis has been investigated. Ferroptosis is a type of cell death that relies on iron and is characterized by unique morphological, biochemical, and genetic features. Unlike other forms of cell death, such as autophagy, apoptosis, necrosis, and pyroptosis, ferroptosis is primarily driven by lipid peroxidation. Ferroptosis cells may be immunogenic, amplify inflammatory responses, cause more cell death, and ultimately induce multi-organ failure. An increasing number of studies have indicated the significance of ferroptosis in sepsis and its role in reducing inflammation. The effectiveness of sepsis treatment has been demonstrated by the use of drugs that specifically target molecules associated with the ferroptosis pathway, including ferroptosis inhibitors. Nevertheless, there is a scarcity of studies investigating the multi-organ dysfunction caused by ferroptosis in sepsis. This article presents a summary and evaluation of recent progress in the role of ferroptosis through molecularly regulated mechanisms and its potential mechanisms of action in the multi-organ dysfunction associated with sepsis. It also discusses the current challenges and prospects in understanding the connection between sepsis and ferroptosis, and proposes innovative ideas and strategies for the treatment of sepsis.

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Effects of low-intensity exercise on contractile property of skeletal muscle and the number of motor neurons in diabetic rats

Tamaki,

Muramatsu,

Ikutomo

et al. 2023

Anat Sci Int

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Aging and low-intensity exercise change oxidative biomarkers in brain regions and radiographic measures of femur of Wistar rats

Cited by 6 publications

References 35 publications

Análisis Descriptivo de un Modelo de Osteoporosis Inducida en Ratas (Rattus norvegicus)

Análisis Descriptivo de un Modelo de Osteoporosis Inducida en Ratas (Rattus norvegicus)

The Emerging Role of Ferroptosis in Sepsis, Opportunity or Challenge?

Effects of low-intensity exercise on contractile property of skeletal muscle and the number of motor neurons in diabetic rats

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