Age-related differences in clinical characteristics of Kawasaki disease

Yu, Peng; Liu, Xiaohui; Duan, Zhao; Cai, Sufen; Duan, Junkai; Zhou, Yujiao

doi:10.1590/1414-431x202010281

Cited by 4 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, a recent study conducted by Ankur Kumar Jindal from Northwest India found that IVIG resistance, CALs, myocarditis, and Kawasaki disease shock syndrome (KDSS) were common in children older than 10 years old (45). Our findings agreed with these studies that older age was a risk factor for the occurrence of IVIG resistance and cardiovascular complications, including myocarditis, valve regurgitation as well as KDSS (45)(46)(47)(48)50). Delay in diagnosis and initiation of standard treatment has been considered to be the most important risk factor for the development of IVIG resistance and cardiovascular complications in this age group (45,47,48,51).…”

Section: Discussionsupporting

confidence: 89%

“…Many studies aimed to investigate the clinical features of KD outside the usual age range. Despite the criteria for the definition of older children varied greatly among different studies, the conclusion was relatively consistent that older children had an increased risk of IVIG resistance and coronary artery sequalae (45)(46)(47)(48)(49). For instance, a recent study conducted by Ankur Kumar Jindal from Northwest India found that IVIG resistance, CALs, myocarditis, and Kawasaki disease shock syndrome (KDSS) were common in children older than 10 years old (45).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive Value of the Systemic Immune-Inflammation Index for Intravenous Immunoglobulin Resistance and Cardiovascular Complications in Kawasaki Disease

Liu

Shao

Wang

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: The prediction of intravenous immunoglobulin (IVIG) resistance and cardiovascular complications are critically clinical issues in Kawasaki disease (KD). This prospective study firstly aimed to determine the predictive ability of the systemic immune inflammation index (SII) for IVIG resistance and cardiovascular complications and compare the prognostic accuracy of SII with that of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR).Methods: Patients with KD were divided into different groups according to the presence of IVIG resistance or cardiovascular complications (coronary artery lesions, valve regurgitation, myocarditis, pericardial effusion, and Kawasaki disease shock syndrome [KDSS]). The clinical and laboratory parameters were compared. Further analysis stratified by platelet level was performed. Multivariate logistic regression analysis was used to identify predictors for IVIG resistance and cardiovascular complications. The receiver operating characteristic (ROC) curve was applied to assess and compare the ability of SII, NLR, and PLR for predicting IVIG resistance and cardiovascular complications.Results: SII was significantly higher in KD patients with IVIG-resistance, myocarditis, valve regurgitation, and KDSS. It was identified as an independent risk factor for IVIG resistance, myocarditis, and valve regurgitation. For KD patients with thrombocytopenia, there were no significant differences in SII between KD patients with IVIG resistance/cardiovascular complications and those without. The best cutoff values of SII for IVIG resistance, myocarditis, valve regurgitation, and KDSS prediction in the whole cohort were 1331.4 × 109, 1368.6 × 109, 1002.4 × 109, and 1485.4 × 109, with a corresponding sensitivity of 0.525, 0.614, 0.754, and 0.670, a specificity of 0.711, 0.723, 0.584, and 0.730, respectively. The predictive value of SII for both IVIG resistance and cardiovascular complications were not superior to that of NLR.Conclusion: Although the parameter of SII may predict IVIG resistance, myocarditis, valve regurgitation, and KDSS in KD as a single parameter, its predictive ability was not good enough and not superior to NLR. SII might not be applicable in patients with KD having thrombocytopenia.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Predictive Value of the Systemic Immune-Inflammation Index for Intravenous Immunoglobulin Resistance and Cardiovascular Complications in Kawasaki Disease

Liu

Shao

Wang

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Kawasaki disease patients with abdominal symptoms have a higher risk of being resistant to IVIG as well as developing coronary aneurysms [69]. Apart from that, the likelihood of patients who are less than one year old to have gastrointestinal symptoms and subsequently coronary artery aneurysm is higher [70]. In terms of pseudo-obstruction, the incidence is unusual to occur [71].…”

Section: Gastrointestinal Systemmentioning

confidence: 99%

“…Around 3% of patients in Southern Malaysia had musculoskeletal manifestations whereas 11% of patients with KD in China had arthritis [8,54]. Older children seem to be more likely to have arthritis when compared to those who are younger [54,70]. This is most probably due to a better understanding and communication skills among the older patients, who complain about their pain better than the younger patients [55].…”

Section: Musculoskeletal Systemmentioning

confidence: 99%

Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features

et al. 2022

View full text Add to dashboard Cite

Kawasaki disease (KD) has shown a marked increase in trend over the globe, especially within the last two decades. Kawasaki disease is often seen in the paediatric population below five years old, while it is rare for those who are beyond that age. Up to this date, no exact causes has been identified although KD was found more than half a century ago. The underlying pathogenesis of the disease is still unelucidated, and researchers are trying to unlock the mystery of KD. To further complicate the diagnosis and the prompt management, a specific biomarker for the diagnosis of KD is yet to be discovered, making it hard to differentiate between KD and other diseases with a similar presentation. Nonetheless, since its discovery, clinicians and scientists alike had known more about the different clinical aspects of typical KD. Thus, this article intends to revisit and review the various clinical manifestations and laboratory characteristics of KD in order to guide the diagnosis of KD.

show abstract

Immunotherapy of multisystem inflammatory syndrome in children (MIS-C) following COVID-19 through mesenchymal stem cells

Suksatan

Chupradit

Yumashev

et al. 2021

International Immunopharmacology

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus causing coronavirus 2019 (COVID-19) that was first observed in Wuhan, China, in Dec. 2019. An inflammatory immune response targeting children appeared during the pandemic, which was associated with COVID-19 named multisystem inflammatory syndrome in children (MIS-C). Characteristics of MIS-C include the classic inflammation findings, multi-organ dysfunction, and fever as the cardinal feature. Up to now, no specific therapy has been identified for MIS-C. Currently, considerable progress has been obtained in the MIS-C treatment by cell therapy, specially Mesenchymal stem cells (MSCs). Unique properties have been reported for MSCs, such as various resources for purification of cell, high proliferation, self-renewal, non-invasive procedure, tissue regenerator, multidirectional differentiation, and immunosuppression. As indicated by a recent clinical research, MSCs have the ability of reducing disease inflammation and severity in children with MIS-C. In the present review study, the benefits and characteristics of MSCs and exosomes are discussed for treating patients with MIS-C.

show abstract

Age-related differences in clinical characteristics of Kawasaki disease

Cited by 4 publications

References 28 publications

Predictive Value of the Systemic Immune-Inflammation Index for Intravenous Immunoglobulin Resistance and Cardiovascular Complications in Kawasaki Disease

Predictive Value of the Systemic Immune-Inflammation Index for Intravenous Immunoglobulin Resistance and Cardiovascular Complications in Kawasaki Disease

Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features

Immunotherapy of multisystem inflammatory syndrome in children (MIS-C) following COVID-19 through mesenchymal stem cells

Contact Info

Product

Resources

About