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Cited by 9 publications
(6 citation statements)
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“…Stress-induced decreases in levels of BDNF in the mouse hippocampus and the ventromedial prefrontal cortex is effectively restored with ketamine administration ( 102 105 ). Ketamine also acutely increases BDNF levels in the hippocampus and amygdala ( 106 111 ), dentate gyrus ( 109 ), and serum ( 112 ) of rodents. Administration of a TrkB inhibitor to the hippocampus blocks ketamine’s behavioral and molecular effects in a rat model of depression ( 81 , 113 ).…”
Section: Resultsmentioning
confidence: 99%
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“…Stress-induced decreases in levels of BDNF in the mouse hippocampus and the ventromedial prefrontal cortex is effectively restored with ketamine administration ( 102 105 ). Ketamine also acutely increases BDNF levels in the hippocampus and amygdala ( 106 111 ), dentate gyrus ( 109 ), and serum ( 112 ) of rodents. Administration of a TrkB inhibitor to the hippocampus blocks ketamine’s behavioral and molecular effects in a rat model of depression ( 81 , 113 ).…”
Section: Resultsmentioning
confidence: 99%
“…Significantly increased levels of BDNF promotor IV’s transcriptional activity has also been found post-ketamine ( 118 ). Ketamine decreases levels of a transcriptional regulator, histone deacetylase (HDAC), in the mouse striata, hippocampus, and PFC ( 109 ). However, knocking out histone deacetylase 5 (HDAC5) resulted in a dysregulated increase of BDNF, which abolished ketamine-induced increases ( 118 ).…”
Section: Resultsmentioning
confidence: 99%
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“…3a, b ). Moreover, the increase of mTORC1 activation caused by the rapid-antidepressant Ketamine promotes the expression of BDNF [ 26 , 27 ]. To mimic the effect of mTORC1 activity changes in depression in vivo, HT-22 and BV2 were treated with mTORC1 inhibitor rapamycin (200 nM), and then the changes of Pdcd4 and BDNF expression were measured by western blot and ELISA.…”
Section: Resultsmentioning
confidence: 99%