2020
DOI: 10.1590/1414-431x20199175
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Abstract: a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, ha… Show more

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Cited by 6 publications
(2 citation statements)
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References 38 publications
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“…Therefore, it is believed that the in ammatory and oxidative stress responses are the underlying mechanisms of epilepsy neuropathology. In this experiment, we chose the PTZ-induced epilepsy model as it is similar to the human epilepsy model [36] , and PTZ is related to nerve excitotoxicity and the expression of reactive oxygen species [37] . JAK2/STAT3 is an important in ammatory response-related pathway.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, it is believed that the in ammatory and oxidative stress responses are the underlying mechanisms of epilepsy neuropathology. In this experiment, we chose the PTZ-induced epilepsy model as it is similar to the human epilepsy model [36] , and PTZ is related to nerve excitotoxicity and the expression of reactive oxygen species [37] . JAK2/STAT3 is an important in ammatory response-related pathway.…”
Section: Discussionmentioning
confidence: 99%
“…However, like all other members of the ARK family, BRSKs are downstream signaling targets of the Ser/Thr kinase LKB1 and also have the potential to be regulated by CAMKII, PAK1, and PKA, suggesting signal-dependent phosphorylation as a central regulatory mechanism (Alessi, Sakamoto, and Bayascas 2006; Lizcano et al 2004; Nie et al 2012; Bright, Carling, and Thornton 2008). BRSKs are highly expressed in the brain and central nervous system of model organisms, where they exhibit both distinct and redundant molecular functions (Kishi et al 2005; Nakanishi et al 2019); furthermore, they are implicated in several human pathologies, in particular neurodevelopmental disorders such as autism spectrum disorder (Saiyin et al 2017; Li et al 2020; Deng et al 2022).…”
Section: Introductionmentioning
confidence: 99%