Carotid intima-media thickness and plaques in internal carotid artery as surrogate markers of lower limb arterial lesions in Chinese patients with diabetic foot

Zhang, Mei; Wen, Xiaorong; Zhou, Chenyun; Huang, Jing; He, Ying

doi:10.1590/1414-431x20198432

Cited by 7 publications

(3 citation statements)

References 34 publications

(36 reference statements)

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“…A study in Japan which compared the flow-mediated vasodilation (FMD) in the brachial artery with CIMT to assess the severity of CAD showed the CIMT cut-off value of 0.88 mm, with 88% sensitivity, 90% specificity, and 92% AUC [52]. Another investigation regarding the use of CIMT as a prediction marker to assess lower leg artery lesions in diabetic patient feet obtained the CIMT cut-off point of 0.71 mm, with a sensitivity of 79.6%, specificity of 61.1%, and AUC of 74.7% [53]. However, a meta-analysis assessing 22 eligible studies found that the common sensitivity and specificity o CIMT for the diagnosis of CAD were 68% and 70%, respectively.…”

Section: Discussionmentioning

confidence: 99%

The Association of Carotid Intima-Media Thickness with the Severity of Stenosis Assessed by the Gensini Score in Coronary Artery Disease Patients

Heriadi¹,

Hasballah²,

Gani³

et al. 2022

IJRP

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Coronary artery disease (CAD), caused by atherosclerosis, is the leading cause of mortality worldwide. Acehnese people own unique cultures with many traditional events involving various cuisines and possess daily habits that increase the risk of CAD. Measurement of carotid intima-media thickness (CIMT) using ultrasonography (USG) has been considered a non-invasive, inexpensive, and safe procedure to assess atherosclerosis in patients. The aim of this study was to evaluate the association between CIMT and the severity of stenosis assessed by the Gensini score among Acehnese CAD patients. A cross-sectional study was conducted at Dr. Zainoel Abidin Hospital, Banda Aceh from April to June 2022. CIMT was measured using ultrasonography and the severity of coronary stenosis was determined through the Gensini scoring system. The cut-off value of CIMT was also analyzed using the receiver operating characteristic (ROC) curve. Using SPSS software, the Chi-Square test was employed to evaluate the relationship between the two variables, and a p<0.05 was considered statistically significant. A total of 51 CAD patients were enrolled in the study and most of them were males (84.3%). More than half (58.8%) of the patients had abnormal CMIT (≥0.9 mm) with an overall CIMT mean of 1,02 ± 0,30 mm. Severe stenosis was observed in 41 patients (80.4%) with an average Gensisni score of 62.65±51.10. Chi-Square analysis revealed a significant association between CIMT and the severity of coronary stenosis among Acehnese CAD patients (p=0.039). The cut-off value for CIMT towards the Gensini score was 0.92 mm with a sensitivity of 60.9% and specificity of 80.0%, suggesting that CIMT could accurately predict the severity of stenosis in the CAD patients of the present study.

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Section: Discussionmentioning

confidence: 99%

The Association of Carotid Intima-Media Thickness with the Severity of Stenosis Assessed by the Gensini Score in Coronary Artery Disease Patients

Heriadi¹,

Hasballah²,

Gani³

et al. 2022

IJRP

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“…It is associated with the incidence of plaques on the internal carotid artery in 1-2 years. 14,15 We have performed this study to estimate and determine the frequency of asymptomatic carotid artery intima-media thickness in patients with type II diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Carotid Artery Stenosis among Patients with Type II Diabetes Mellitus

Shahid¹,

Khattak²,

Bukhari³

et al. 2021

J. Bahria Univ. Med. Dent. Coll.

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Objectives: To assess Carotid artery intima-media thickness in patients with type II diabetes mellitus. Study design and setting: This descriptive cross-sectional study was conducted at Department of Medicine, CMH Quetta from June 2018 to May 2019. Methodology: Total 176 known type II diabetes mellitus (DM) patients were included in study. Age ranged from 30-70 years. Patients using statin drugs, chronic kidney disease and decompensated liver cirrhosis were excluded. Carotid artery ultrasonography was carried out by radiologist. Carotid artery intima-media thickness (CIMT) was achieved with a 7 MHz B-mode ultrasound system. The intima-media thickness (IMT) was demarcated as the distance between the leading edge of the luminal echo to the leading edge of the adventitia of the media. This distance was measured during the diastolic phase. This was measured 3 cm before the carotid bifurcation. Also, carotid bifurcation and internal carotid artery 2 cm distally from the carotid bifurcation was scanned. Results: Mean age was 47.86 ± 6.46 years. Most of the patients 125 (71.02%) were consisted of 30 to 50 years of age. Among them the 176 patients, 92 (52.27%) were male and 84 (47.73%) were females. Male to female ratio comprised of 1.1:1. Results further revealed that 43(24.43%) patients showed asymptomatic Carotid artery intima-media thickness. Rest there was no asymptomatic Carotid artery intima-media thickness in 133 (75.57%) patients. Conclusion: This study determined that the frequency of asymptomatic Carotid artery intima-media thickness in patients with type II diabetes mellitus is quite high.

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“…IMT can be used for early identification of subclinical atherosclerotic disease [80]. Carotid IMT can be a predictor of multi-territory atherosclerosis [81]. ATS detected in a single vascular segment indicates potential damage in other segments [69].…”

Section: Atherosclerosis and Its Evaluation Methodsmentioning

confidence: 99%

Diabetic Vascular Damage: Review of Pathogenesis and Possible Evaluation Technologies

et al. 2019

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Diabetes mellitus (DM) is a rapidly increasing problem in health care worldwide: recent forecast indicates that the number of DM patients will rise to 640 million by 2040. Vascular damage is associated with severe complications, including cardiac neuropathy and limb amputation. Therefore, early prediction of diabetic vascular damage using advanced technologies is an important challenge because timely preventive and therapeutic measures could diminish the risk of development and burden of complications. The aim of the article is to provide a review of the initial stages of vascular damage and main mechanisms for development, as well as appropriate modern technologies for prediction and diagnosis. The manuscript provides an overview of interrelated vascular damage mechanisms influenced by diabetes, along with a review of possible technologies for early prediction and diagnosis. A comparative analysis of technologies appropriate for particular issues of prediction is summarised in the discussion.INDEX TERMS Arterial stiffness and atherosclerosis, diabetes mellitus vascular complications, endothelial dysfunction, evaluation technologies. V. DEVELOPMENT OF INTIMA AND MEDIA CALCIFICATION AND ITS EVALUATION METHODS

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Carotid intima-media thickness and plaques in internal carotid artery as surrogate markers of lower limb arterial lesions in Chinese patients with diabetic foot

Cited by 7 publications

References 34 publications

The Association of Carotid Intima-Media Thickness with the Severity of Stenosis Assessed by the Gensini Score in Coronary Artery Disease Patients

The Association of Carotid Intima-Media Thickness with the Severity of Stenosis Assessed by the Gensini Score in Coronary Artery Disease Patients

Asymptomatic Carotid Artery Stenosis among Patients with Type II Diabetes Mellitus

Diabetic Vascular Damage: Review of Pathogenesis and Possible Evaluation Technologies

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