2018
DOI: 10.1590/1414-431x20176520
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Abstract: Multiple growth factors can be administered to mimic the natural process of bone healing in bone tissue engineering. We investigated the effects of sequential release of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone regeneration. To improve the double emulsion/solvent evaporation technique, VEGF was encapsulated in PELA microcapsules, to which BMP-2 was attached. The scaffold (BM… Show more

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Cited by 16 publications
(14 citation statements)
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“…In addition, the biophysical signals triggered by ES are used for a wide range of bone disorders, and various of growth factors, such as bone morphogenetic proteins (BMPs), epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1) have also been implicated in osteogenesis[ 11 14 ]. Evidence indicates that IGF-I is one of the most abundant growth factors in the bone matrix, which influences a wide range of physiological functions, including growth, differentiation and metabolism[ 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the biophysical signals triggered by ES are used for a wide range of bone disorders, and various of growth factors, such as bone morphogenetic proteins (BMPs), epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1) have also been implicated in osteogenesis[ 11 14 ]. Evidence indicates that IGF-I is one of the most abundant growth factors in the bone matrix, which influences a wide range of physiological functions, including growth, differentiation and metabolism[ 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…Osteoblast differentiation was also significantly increased with the scaffolds. These results highlight the potential for use of this method for treatment of further bone defects [ 59 ]. Similarly, another study used hydroxyapatite collagen scaffolds with VEGF and observed GF release in vitro and in vivo in the rat model.…”
Section: Desired Characteristics Of 3d Scaffoldsmentioning
confidence: 96%
“…Table 2 summarizes the advanced fabrication techniques that can allow for a vast range of materials to be used in BTE. [40][41][42][43][44][45][46][47] The mimicking of the native tissue architecture and composition at a microscopic level is of high importance for the development of more complete and efficient tissue engineering approaches that more closely resemble natural bone.…”
Section: Micrometric Approachesmentioning
confidence: 99%
“…There is an ample group of biomaterials, from natural to synthetic, that can be used for microparticles production such as HAp, chitosan, gelatin, PGLA, or polylactide-poly(ethylene glycol) (PELA), among others. [43][44][45][46][47] Figure 6. Bone microstructure and some of the most common approaches to mimic its hierarchical structure.…”
Section: Microparticlesmentioning
confidence: 99%