2017
DOI: 10.1590/1414-431x20176353
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Abstract: This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intesti… Show more

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Cited by 13 publications
(7 citation statements)
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“…However, other studies showed low intestinal absorption of curcumin. The reason for the low bioavailability of oral curcumin may be related to its low solubility and the efflux effect of P-gp and MRP2 in intestinal epithelial cells during intestinal absorption [35]. In this toxicity study, we did not observe the curcumin absorption.…”
Section: Discussioncontrasting
confidence: 56%
“…However, other studies showed low intestinal absorption of curcumin. The reason for the low bioavailability of oral curcumin may be related to its low solubility and the efflux effect of P-gp and MRP2 in intestinal epithelial cells during intestinal absorption [35]. In this toxicity study, we did not observe the curcumin absorption.…”
Section: Discussioncontrasting
confidence: 56%
“…It was found that in the rat small intestine, curcumin was best absorbed at the duodenal segment, followed by the jejunum and colon. The absorption of curcumin in the ileum was the poorest (Wang et al, 2017a).…”
Section: Low Permeability (Absorption)mentioning
confidence: 99%
“…In transcellular studies, apparent permeability coefficient (Papp) was used to represent the amount of compound transported per unit time (Wang et al, 2017a). It was reported that the value of Papp is correlated to the extent of drug molecules that penetrate across the intestinal tract of the drugs (Artursson and Karlsson, 1991;Ozeki et al, 2015;).…”
Section: Low Permeability (Absorption)mentioning
confidence: 99%
“…In addition, we also found the P app values of the hyperin quercitrin, and quercetin were lower than 3 × 10 -6 cm•s −1 in the four segments, however the P app values of the phloridzin and phloretin were between 3 × 10 -6 cm•s −1 and 2×10 -5 cm•s −1 in jejunum. It has been reported in the literature that at a P app value of < 3 × 10 -6 cm•s −1 , the drug is not well absorbed, whereas at a P app value of > 2×10 -5 cm•s −1 , the drug is well absorbed [33,34].…”
Section: Discussionmentioning
confidence: 99%