Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow

Shen, Jichun; Zhang, Y.C.; Zhao, Mingfeng

doi:10.1590/1414-431x20176087

Cited by 9 publications

(8 citation statements)

References 38 publications

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“…Which may increase the risk of asthma. Fe overload may lead to various disorders [57]. Our findings showed that asthma had markedly higher level of Fe than that in controls among overall populations and Asians, which was consistent with the above-mentioned evidence.…”

Section: Discussionsupporting

confidence: 91%

Association between trace elements levels and asthma susceptibility

Mao

Shi

2018

Respiratory Medicine

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Background: It is well-documented that the dysregulation of trace elements may be involved in the pathogenesis of asthma. However, the precise changes of trace elements levels in asthma cases remain elusive. We established whether trace elements levels were associated with asthma susceptibility by pooling case-control studies. Methods: 34 studies were included. We extracted the standard mean differences (SMDs) and corresponding 95% confidence intervals (CIs). A pooled-analysis was performed. Results: No marked difference (95% CI:-1.437-0.218, p = 0.149) of Se level between asthma and controls. Significant difference (95% CI: 0.112-1.032, p = 0.015; 95% CI: 0.376-1.331, p < 10 −4) of Cu level between asthma and controls was noted among overall populations and Asians. No marked difference of Zn level between asthma and controls was observed among overall populations, Asians, Caucasians and Africans. Significant difference (95% CI:-0.567 to −0.238, p < 10 −4) of Mg level between asthma and controls was noted among Asians. Marked difference (95% CI: 0.258-2.864, p = 0.019; 95% CI: 0.270-3.282, p = 0.021) of Fe level between asthma and controls was noted among overall populations and Asians. Age had no impact on the pooled SMDs of Se, Cu, Zn, Mg and Fe between asthma and controls. Sensitivity analyses did not change the overall results. No publication bias was noted for overall populations. Conclusions: Alterations of Cu, Mg and Fe levels may be a biomarker of asthma risk among specific populations. Further studies should be performed to clarify the strength of these elements in asthma.

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Section: Discussionsupporting

confidence: 91%

Association between trace elements levels and asthma susceptibility

Mao

Shi

2018

Respiratory Medicine

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“…A previous study showed that iron overload could change the frequency and function of normal hematopoietic stem and progenitor cells, especially in erythroid cells 17 . Our findings are consistent with another study which found that iron overload may postpone hematopoietic recovery following BM transplantation, suggesting that iron overload may affect the hematopoietic microenvironment of BM 18 …”

Section: Discussionsupporting

confidence: 91%

“…17 Our findings are consistent with another study which found that iron overload may postpone hematopoietic recovery following BM transplantation, suggesting that iron overload may affect the hematopoietic microenvironment of BM. 18 Subsequently, observations revealed that colony formation, peripheral RBC counts and HGB concentration were reduced, while platelet counts were increased in response to iron overload after allo-HSCT. In a previous study conducted by Chai 20 Another study demonstrated that decreased RBC counts were associated with reduced complications related to transfusion as secondary iron overload.…”

Section: Allo-hsct In An Iron-overloaded Mice Negatively Impacts Sumentioning

confidence: 99%

Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Lin

Chen

et al. 2020

The Kaohsiung J of Med Scie

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Hematological malignancies are increasingly treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Unfortunately, iron overload is a frequent adverse effect of allo-HSCT and is associated with poor prognosis. In the present study, we investigated hematopoiesis in iron-overloaded mice and elucidated the effects of iron overload on the bone marrow (BM) microenvironment. Ironoverloaded BALB/C mice were generated by injecting 20 mg/mL saccharated iron oxide intraperitoneally. Hematoxylin-eosin staining was performed to evaluate the effects of an iron overload in mice. BM cells obtained from C57BL/6 mice were transplanted into irradiated BALB/C mice (whole-body irradiation of 4 Gy, twice with a 4-hours interval) by tail vein injection. Two weeks after allo-HSCT, the hematopoietic reconstitution capacity was evaluated in recipients by colony-forming assays. Histopathological examinations showed brown-stained granular deposits, irregularly arranged lymphocytes in the liver tissues, and blue-stained blocks in the BM collected from mice received injections of high-dose saccharated iron oxide (20 mg/mL). Ironoverloaded mice showed more platelets, higher-hemoglobin (HGB) concentration, fewer granulocyte-macrophage colony-forming units (CFU-GM), erythrocyte colonyforming units (CFU-E), and mixed granulocyte/erythrocyte/monocyte/megakaryocyte colony-forming units (CFU-mix) than healthy mice. Iron-overloaded recipients presented with reduced erythrocytes and HGB concentration in peripheral blood, along with decreased marrow stroma cells, CFU-GM, CFU-E, and CFU-mix relative to healthy recipients. Taken together, our findings demonstrate that iron overload might alter the number of red blood cells after transplantation in mice by destroying the

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“…Because of these mechanisms, it could be observed that, there was significant reduction in level of both malondialdehyde MDA and cyclic adenosine monophosphate CAMP in group II which are treated with the combination of deferoxamine and NAC. Shen et al (2017) supports the current study by his observation about the improvement of bone marrow damage due to accumulation of reactive oxygen species (ROS) after acute iron toxicity when treated with the combination of deferoxamine and oral NAC.…”

Section: Discussionsupporting

confidence: 89%

Efficacy of Intravenous N-acetylcysteine As an Adjuvant Therapy in Acute Iron Toxicity in Rats

Hodeib

Dawood

Fayed

2020

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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KEYWORDSAcute Iron Toxicity; Intravenous N-acetylcysteine; Antioxidant; Deferoxamine.Iron is a one of the heavy metals that is necessary for cell function. Acute and chronic exposure to high dose leads to oxidative damage. In the liver, iron overload affect hepatic mitochondrial respiration. Deferoxamine is well established antidote for iron toxicity which acts as a chelator. N-acetylcysteine (NAC) is a safe over the counter mucolytic which is antioxidant and glutathione substitute properties. Its use as an antidote for some toxins is well established nowadays. The aim of this work is to study the efficacy of intravenous N-acetylcysteine as an adjuvant therapy with deferoxamine in acute iron intoxication in rats. This study was carried out on twenty male albino rats, weighted 200-250 gm and divided into group I: 10 rats received 400 mg/kg elemental iron orally followed by 25 mg/kg subcutaneous deferoxamine and group II: 10 rats received 400 mg/kg elemental iron followed by 150 mg/kg IV NAC and 25 mg/kg subcutaneous deferoxamine. The results revealed that N-acetylcysteine use lowered both oxidative stress markers malondialdehyde MDA and cyclic adenosine monophosphate cAMP. On the other hand, the reduction of serum and hepatic iron levels and the elevation of Alanine Transaminase (ALT) and Aspartate Aminotransferase (AST) were statistically insignificant. It was concluded that intravenous N-acetylcysteine helps in reduction of oxidative stress caused by acute iron toxicity.

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Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow

Cited by 9 publications

References 38 publications

Association between trace elements levels and asthma susceptibility

Association between trace elements levels and asthma susceptibility

Iron overload as a risk factor for poor graft function following allogeneic hematopoietic stem cell transplantation

Efficacy of Intravenous N-acetylcysteine As an Adjuvant Therapy in Acute Iron Toxicity in Rats

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