2016
DOI: 10.1590/1414-431x20155001
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Abstract: Various methods are available for preservation of vascular grafts for pulmonary artery (PA) replacement. Lyophilization and cryopreservation reduce antigenicity and prevent thrombosis and calcification in vascular grafts, so both methods can be used to obtain vascular bioprostheses. We evaluated the hemodynamic, gasometric, imaging, and macroscopic and microscopic findings produced by PA reconstruction with lyophilized (LyoPA) grafts and cryopreserved (CryoPA) grafts in dogs. Eighteen healthy crossbred adult d… Show more

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Cited by 4 publications
(3 citation statements)
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“…In vascular tissue engineering (VTE), lyophilization helps to produce stable, dry grafts, the properties of which remain preserved, but the process of calcification is reduced, helping in the long‐term storage of the graft. [ 71 ] A study has used lyophilized grafts made of PGA and poly caprolactone‐ co ‐lactide (PCLA) for use in VTE with a diameter of the order of millimeters (0.91 mm) and a wall thickness of 300 µm. [ 72 ] Dual phase separation and lyophilization were used to develop vascular scaffolds using PLLA, poly( l ‐lactide‐ co ‐caprolactone) (PLCL), and poly(lactic‐ co ‐glycolic acid) (PLGA), with an outer microporous layer allowing SMC infiltration and a microporous inner layer supporting endothelialization.…”
Section: Techniques Used For Fabricating Vasculaturementioning
confidence: 99%
“…In vascular tissue engineering (VTE), lyophilization helps to produce stable, dry grafts, the properties of which remain preserved, but the process of calcification is reduced, helping in the long‐term storage of the graft. [ 71 ] A study has used lyophilized grafts made of PGA and poly caprolactone‐ co ‐lactide (PCLA) for use in VTE with a diameter of the order of millimeters (0.91 mm) and a wall thickness of 300 µm. [ 72 ] Dual phase separation and lyophilization were used to develop vascular scaffolds using PLLA, poly( l ‐lactide‐ co ‐caprolactone) (PLCL), and poly(lactic‐ co ‐glycolic acid) (PLGA), with an outer microporous layer allowing SMC infiltration and a microporous inner layer supporting endothelialization.…”
Section: Techniques Used For Fabricating Vasculaturementioning
confidence: 99%
“…The lyophilized grafts can easily be sterilized with ethylene oxide or gamma radiation ( 69 ). This technique does not change the polymeric properties, such as the mechanical characteristics; it reduces calcification and allows for graft storage for later use ( 70 ). Reinhardt and colleagues developed lyophilized vascular scaffolds from poly (glycolic acid) (PGA) and polycaprolactone-co-lactide (PCLA).…”
Section: Vte Techniquesmentioning
confidence: 99%
“…They suggested that the lyophilisation techniques may play in favour of less antigenicity, as well as preventing thrombosis and calcification of the grafts. Finally, they concluded that the lyophilisation without treatment with glutaraldehyde represents a feasible alternative with promising clinical results 20.…”
mentioning
confidence: 99%