2018
DOI: 10.1590/1414-431x20154547
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Abstract: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. We reviewed the records of 1… Show more

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Cited by 11 publications
(8 citation statements)
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“…It has been reported that CD4 + T cells and CD4 + /CD8 + T cells are significantly lower in SLE with infection than without infection, whereas CD8 + T cells are significantly greater than non-infected patients. 13 Lanio et al. also demonstrated that abnormal T lymphocytes had a role in the development of infection.…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…It has been reported that CD4 + T cells and CD4 + /CD8 + T cells are significantly lower in SLE with infection than without infection, whereas CD8 + T cells are significantly greater than non-infected patients. 13 Lanio et al. also demonstrated that abnormal T lymphocytes had a role in the development of infection.…”
Section: Discussionmentioning
confidence: 98%
“…11,12 Hence, finding a suitable laboratory test to identify bacterial infection and disease relapse in SLE is essential. 13…”
Section: Introductionmentioning
confidence: 99%
“…Wolfe and Peacock described that lymphopenia and low CD4 + T cell count are risk factors of pneumocystis pneumonia in connective tissue diseases (18). Wu et al (19) reported that the CD4 + T cell number and the CD4/CD8 ratio as well as immunoglobulin G level were lower in SLE patients with infection than in those without infection. It is not clear whether decreased CD4 + T cell number and CD4/CD8 ratio relate to the nature of the autoimmune disease or the immunosuppressive agents.…”
Section: Discussionmentioning
confidence: 99%
“…Defects in the cellular and humoral immune system in SLE increase the risk of infection. 15 The susceptibility to infection is further escalated in patients with LN because of renal dysfunction and exposure to an intense immunosuppressive regimen. 2,16,17 Previous studies have shown that variation in infection-related mortality rates in LN could be attributed to several factors including patient age, socioeconomic status, geographic distribution, ethnicity and access to healthcare.…”
Section: Discussionmentioning
confidence: 99%