2015
DOI: 10.1590/1414-431x20144261
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Abstract: Amfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vascular effects when applied in vitro to rat aortic rings and, if so, what mechanisms may be involved. We analyzed the effect of amfepramone on phenylephrine-pr… Show more

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Cited by 8 publications
(7 citation statements)
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“…According to the findings of the present study, on the other hand, fenproporex [2], amfepramone [31], clobenzorex [17] and T 3 [27] administered under certain conditions do not increase blood pressure, but instead generate endothelium-dependent vasodilation via nitric oxide, potassium and voltage-dependent calcium channels. Consequently, these drugs could probably be used without adverse cardiovascular effects [2,17,27,31]. Further research is needed to explore the possible involvement of type M1 muscarinic receptors in the mechanism of action of the aforementioned drugs, a mechanism suggested in previous reports.…”
Section: Final Considerationsmentioning
confidence: 63%
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“…According to the findings of the present study, on the other hand, fenproporex [2], amfepramone [31], clobenzorex [17] and T 3 [27] administered under certain conditions do not increase blood pressure, but instead generate endothelium-dependent vasodilation via nitric oxide, potassium and voltage-dependent calcium channels. Consequently, these drugs could probably be used without adverse cardiovascular effects [2,17,27,31]. Further research is needed to explore the possible involvement of type M1 muscarinic receptors in the mechanism of action of the aforementioned drugs, a mechanism suggested in previous reports.…”
Section: Final Considerationsmentioning
confidence: 63%
“…Amfepramone, also known as diethylpropion, is a sympathetic mimetic amine similar to amphetamines that stimulates the central nervous system and increases blood pressure. It is an appetite suppressing drug used for the treatment of obesity [7,22,30,31,32]. Monotherapy with this drug demonstrated greater efficacy than the placebo [23].…”
Section: Amfepramonementioning
confidence: 99%
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“…Amfepramone (2-diethylaminopropiophenon) stimulates the central nervous system to suppress appetite by increasing the release of catecholamines (dopamine and noradrenaline) in the hypothalamus and further limits their reuptake [74]. Subsequently, the drug is used as a short-term anorectic agent for the treatment of obesity [75]. Amfepramone is the most frequently abused and illicitly trafficked pharmacological adulterants in herbal weight loss products worldwide [32].…”
Section: Amfepramone (Diethylpropion)mentioning
confidence: 99%