Abstract:The aim of the present study was to determine the mechanisms underlying the relaxant
effect of adrenomedullin (AM) in rat cavernosal smooth muscle (CSM) and the
expression of AM system components in this tissue. Functional assays using standard
muscle bath procedures were performed in CSM isolated from male Wistar rats. Protein
and mRNA levels of pre-pro-AM, calcitonin receptor-like receptor (CRLR), and Subtypes
1, 2 and 3 of the receptor activity-modifying protein (RAMP) family were assessed by
Western immuno… Show more
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