2014
DOI: 10.1590/1414-431x20143459
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Abstract: Neuroblastoma is a solid tumor that occurs mainly in children. Malignant neuroblastomas have a poor prognosis because conventional chemotherapeutic agents are not very effective. Survivin, a member of the inhibitor of the apoptosis protein family, plays a significant role in cell division, inhibition of apoptosis, and promotion of cell proliferation and invasion. Previous studies found that survivin is highly expressed in some malignant neuroblastomas and is correlated with poor prognosis. The aim of this stud… Show more

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Cited by 5 publications
(3 citation statements)
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“…An in vivo study by Kogo et al has shown that survivin knockdown by siRNA significantly delays tumor development and lymph node metastasis in cervical cancer [31] . Directly silencing survivin by siRNA also inhibits invasion in neuroblastoma SH-SY5Y cells [32] . Another in vivo study by Zhang et al has found that the inhibition of survivin dramatically inhibits spontaneous metastasis in Dunning prostate cancer [33] .…”
Section: Wwwchinapharcom Liu MD Et Almentioning
confidence: 98%
“…An in vivo study by Kogo et al has shown that survivin knockdown by siRNA significantly delays tumor development and lymph node metastasis in cervical cancer [31] . Directly silencing survivin by siRNA also inhibits invasion in neuroblastoma SH-SY5Y cells [32] . Another in vivo study by Zhang et al has found that the inhibition of survivin dramatically inhibits spontaneous metastasis in Dunning prostate cancer [33] .…”
Section: Wwwchinapharcom Liu MD Et Almentioning
confidence: 98%
“…Silencing of survivin in human androgen independent prostate cancer using RNAi reduced the proliferative potential and elevated the rate of apoptosis [192]. siRNA directed against survivin in neuroblastoma cell lines completely suppressed the expression at both mRNA and protein levels [193]. Micro RNAs (miRNAs), including miR-203, miR-34a, miR-218, miR-138p, miR-485-p, miR-542-3p and miR-214-3p, delivered to malignant cells using viral or non-viral based delivery systems, bind to survivin and induce gene silencing.…”
Section: Rna Interference (Rnai)mentioning
confidence: 99%
“…54 This cell line had a maximum proliferation that was greater than other cell lines on RGD-modied and also polymer-modied surfaces due to its highly aggressive characteristics. 55,56 Proliferation behaviour of this cell line on polymer- coated and RGD-modied surfaces was further examined by SEM (Fig. S4 †).…”
Section: Cell Culture Studiesmentioning
confidence: 99%