2013
DOI: 10.1590/1414-431x20122085
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Abstract: The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786) were prepared from 2-thienylidene 3,4-methylenedioxybenzoylhydrazine (LASSBio-294). The ability of LASSBio-785 and LASSBio-786 to decrease central nervous system activity was investigated in male Swiss mice. LASSBio-785 or LASSBio-786 (30 mg/kg, ip) reduced locomotor activity from 209 ± 26 (control) to 140 ± 18 (P < 0.05) or 146 ± 15 crossings/min (P < 0.… Show more

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Cited by 3 publications
(1 citation statement)
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“…Spontaneous locomotor activity was measured in an automated open-field apparatus (45×45 cm; LE 8811, Panlab, Hollister, MA, USA) in which 16 infrared photocells were positioned at every 2.5 cm. 25 Normal Wistar rats were placed individually in the center of the chamber, and beam interruptions were counted as instances of motor activity over a 40-minute observation period divided into eight 5-minute intervals. Locomotor activity was measured before as well as 1, 3, and 7 days after treatment with Cris-104 (100 mg/kg by gavage) and reported in the form of number of movements per minute.…”
Section: Methodsmentioning
confidence: 99%
“…Spontaneous locomotor activity was measured in an automated open-field apparatus (45×45 cm; LE 8811, Panlab, Hollister, MA, USA) in which 16 infrared photocells were positioned at every 2.5 cm. 25 Normal Wistar rats were placed individually in the center of the chamber, and beam interruptions were counted as instances of motor activity over a 40-minute observation period divided into eight 5-minute intervals. Locomotor activity was measured before as well as 1, 3, and 7 days after treatment with Cris-104 (100 mg/kg by gavage) and reported in the form of number of movements per minute.…”
Section: Methodsmentioning
confidence: 99%