Survival rates of breast cancer and predictive factors: a hospital-based study from western Amazon area in Brazil

Fujimoto, Ruth Helena Pimenta; Koifman, Rosalina Jorge; Silva, Ilce Ferreira da

doi:10.1590/1413-81232018241.35422016

Cited by 14 publications

(8 citation statements)

References 26 publications

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“…In agreement with what was previously reported in Jordan, 27 Brazil, 45 and Iran 24 patients who were surgically treated showed better survival than those treated with combined therapy of surgery, radiotherapy, and chemotherapy but without significant difference. Contrarily to that reported in Oman, 42 chemotherapy alone was associated with a worse prognosis.…”

Section: Discussionsupporting

confidence: 92%

Three-year Survival of Women with Breast Cancer in Basrah, Iraq

Al-Asadi

Al-Mayah²

2020

Oman Med J

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Objectives We sought to determine the overall observed three-year survival rate of women with breast cancer in Basrah, Iraq, and investigate the associated factors. Methods Data was collected retrospectively from the Oncology Center registry in Basrah, all newly diagnosed women with breast cancer between 1 January 2013 and 31 December 2014 were included and followed-up until 31 December 2017. We used the Kaplan-Meier method to estimate the overall survival rates. Cox regression analysis was used to investigate the association between survival and prognostic factors. Results A total of 605 women who were diagnosed with breast cancer during 2013– 2014 were included in the study, 44.1% had advanced tumor stages (stage III and IV). The overall observed three-year survival rate was 83.3%. Cox regression analysis showed that late stage (stage IV vs. stage I hazard ratio (HR) = 4.65; 95% confidence interval (CI): 3.28–7.81) and grade (poorly vs. well differentiated HR = 4.10; 95% CI: 3.01–6.82) were significantly associated with poor survival. Conclusions The overall observed survival rate of women with breast cancer in Basrah was comparable to that reported for developing countries, but it is poorer than that of developed countries. Advanced stage and poorly differentiated tumors were significant predictors of poor survival.

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Section: Discussionsupporting

confidence: 92%

Three-year Survival of Women with Breast Cancer in Basrah, Iraq

Al-Asadi

Al-Mayah²

2020

Oman Med J

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“…These survivals are close to those observed in other national studies [10,19,20] and lower than those found in countries like U.S.A. and England [5,9].…”

Section: Discussionsupporting

confidence: 88%

“…However, very young women (those under 40 years old) had a 5yOS of 82.2%, signi cantly less than women aged 40 to 49, 87.7% (p = 0.002). Other studies also point to reduced survival in very young women [7,8,20], probably due to the diagnosis of more aggressive molecular types of tumours found in this group.…”

Section: Discussionmentioning

confidence: 91%

Breast Cancer Survival in the Mammography Era in Brazil: A Population-Based Analysis of 2,715 Cases

Fernandes

Machado

Cardoso-Filho

et al. 2021

Preprint

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Background This study aims to assess breast cancer survival rates after one decade of mammography in a large urban area of Brazil. Methods It is a population-based retrospective cohort of women with breast cancer in Campinas, São Paulo, from 2010 to 2014. Age, vital status and stage were accessed through the cancer and mortality registry, and patients records. Statistics used Kaplan-Meier, log-rank and Cox's regression. Results Out of the 2,715 cases, 665 deaths (24.5%) were confirmed until early 2020. The mean age at diagnosis was 58.6 years. Women 50-69 years were 48.0%, and stage I the most frequent (25.0%). The overall mean survival was 8.4 years (8.2-8.5). The 5-year survival (5yOS) for overall, 40-49, 50-59, 60-69, 70-79 years was respectively 80.5%, 87.7%, 83.7%, 83.8% and 75.5%. The 5yOS for stages 0, I, II, III and IV was 95.2%, 92.6%, 89.4%, 71.1% and 47.1%. There was no significant difference in survival in stage I or II (p=0.058). Compared to women 50-59 years, death's risk was 2.3 times higher for women 70-79 years and 26% lower for women 40-49 years. Concerning stage I, the risk of death was 1.5, 4.1 and 8.6 times higher, and 34% lower, respectively, for stage II, III, IV and 0. Conclusions In Brazil, breast cancers are currently diagnosed in the early stages, although advanced cases persist. Survival rates may reflect improvements in screening, early detection and treatment. The results can reflect the current status of other regions or countries with similar health care conditions.

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“…In this study, we demonstrated 5-year OS rate of 58%, a little higher than that reported in Uganda (51.8%), Ghana (47.9%), Indonesia (51.1%), and Malaysia (49%), 32 – 35 and less than that reported from Eastern Mediterranean region (69.2%), India (78%), Vietnam (80.6%), and Brazil (87%). 36 – 39 Yet, this rate was much lower than survival rates in more developed countries such as the United States (91%), Canada (88%), Australia (88.3%), Japan (85.5%), and Western European countries—which generally exceed the limit of 85%. 14 , 16 , 40 The low OS rate observed in African women could be because of late presentation and aggressive nature of BC, together with lack of screening programs and limited access to healthcare services.…”

Section: Discussionmentioning

confidence: 87%

Survival Outcomes of Breast Cancer in Sudanese Women: A Hospital-Based Study

Muddather

Elhassan

Faggad

2021

JCO Global Oncology

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PURPOSE Breast cancer (BC) is the leading malignancy among Sudanese women. Yet, data on survival are limited. This study aimed to determine 5-year overall survival (OS) of BC in Sudanese women, and identify prognostic demographic and clinicopathologic factors. PATIENTS AND METHODS A hospital-based retrospective study was conducted by reviewing data of women with BC diagnosed and treated at the National Cancer Institute—University of Gezira during 2012, and followed up to end of August 2018. Data were retrieved from medical records and analyzed, OS was determined, and the prognostic factors were explored. RESULTS A total of 225 cases were recruited. The median age at presentation was 45 years (range, 22-85 years). Clinical stage I, II, III, and IV represented 3.1%, 31.6%, 48%, and 17.3%, respectively. Most women (81.3%) were treated with curative intent. Of those, 25.1% received neoadjuvant chemotherapy. Mastectomy was the commonest (61.7%) type of surgery. The median follow-up period was 59.8 months with mean OS time of 55.7 months. The 5-year cumulative survival rate was 58%. The 5-year OS rates for stages I, II, III, and IV were 71.5%, 82.4%, 56.5%, and 8.4%, respectively. For lymph node (LN)-positive cases, 5-year OS rate was 63% and for LN-negative was 83.5%. Presenting with advanced-stage disease and positive LN status associated with short OS times ( P < .005). CONCLUSION OS of women with BC in Central Sudan is worse than in the developed world, but similar to African countries. Our findings indicate that advanced stage at diagnosis and lymph nodal involvement are strong predictors of short survival times. Raising awareness and introducing early detection programs are critical for better survival of these patients.

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Survival rates of breast cancer and predictive factors: a hospital-based study from western Amazon area in Brazil

Cited by 14 publications

References 26 publications

Three-year Survival of Women with Breast Cancer in Basrah, Iraq

Three-year Survival of Women with Breast Cancer in Basrah, Iraq

Breast Cancer Survival in the Mammography Era in Brazil: A Population-Based Analysis of 2,715 Cases

Survival Outcomes of Breast Cancer in Sudanese Women: A Hospital-Based Study

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