Análise espaço-temporal da leishmaniose visceral no estado do Maranhão, Brasil

Furtado, Aline Santos; Nunes, Flávia Baluz Bezerra de Farias; Santos, Alcione Miranda dos; Caldas, Arlene de Jesus Mendes

doi:10.1590/1413-812320152012.01672015

Cited by 16 publications

(16 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We used a Bayesian model to better define the risk factors for the spread of VL in São Paulo State, integrating data on its vector and hosts, and to predict the distribution and dispersion of the disease over time and space. As we already cited above, zoonotic VL has been spreading in other regions of Brazil outside of São Paulo [ 77 , 24 , 38 ] and in other countries as well [ 21 ]. Extension of our model to other scenarios can offer further insights into the factors influencing the spread of leishmaniasis and other diseases elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Risk analysis and prediction of visceral leishmaniasis dispersion in São Paulo State, Brazil

et al. 2017

View full text Add to dashboard Cite

Visceral leishmaniasis (VL) is an important neglected disease caused by a protozoan parasite, and represents a serious public health problem in many parts of the world. It is zoonotic in Europe and Latin America, where infected dogs constitute the main domestic reservoir for the parasite and play a key role in VL transmission to humans. In Brazil this disease is caused by the protozoan Leishmania infantum chagasi, and is transmitted by the sand fly Lutzomyia longipalpis. Despite programs aimed at eliminating infection sources, the disease continues to spread throughout the Country. VL in São Paulo State, Brazil, first appeared in the northwestern region, spreading in a southeasterly direction over time. We integrate data on the VL vector, infected dogs and infected human dispersion from 1999 to 2013 through an innovative spatial temporal Bayesian model in conjunction with geographic information system. This model is used to infer the drivers of the invasion process and predict the future progression of VL through the State. We found that vector dispersion was influenced by vector presence in nearby municipalities at the previous time step, proximity to the Bolívia-Brazil gas pipeline, and high temperatures (i.e., annual average between 20 and 23°C). Key factors affecting infected dog dispersion included proximity to the Marechal Rondon Highway, high temperatures, and presence of the competent vector within the same municipality. Finally, vector presence, presence of infected dogs, and rainfall (approx. 270 to 540mm/year) drove the dispersion of human VL cases. Surprisingly, economic factors exhibited no noticeable influence on disease dispersion. Based on these drivers and stochastic simulations, we identified which municipalities are most likely to be invaded by vectors and infected hosts in the future. Prioritizing prevention and control strategies within the identified municipalities may help halt the spread of VL while reducing monitoring costs. Our results contribute important knowledge to public and animal health policy planning, and suggest that prevention and control strategies should focus on vector control and on blocking contact between vectors and hosts in the priority areas identified to be at risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk analysis and prediction of visceral leishmaniasis dispersion in São Paulo State, Brazil

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Among all the Federal states in Brazil, Maranhão, a state in northeastern Brazil has recorded the highest number of cases of HVL. Between 2000 and 2009, 5389 cases of HLV were registered, with the highest incidence in the Regional health unit of Caxias, which reported 36.1 cases per 100,000 inhabitants [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Decentralized control of human visceral leishmaniasis in endemic urban areas of Brazil: a literature review

Menon

Rossi²,

Nshimyumukiza

et al. 2016

Trop Med Health

View full text Add to dashboard Cite

ObjectivesHuman migration and concomitant HIV infections are likely to bring about major changes in the epidemiology of some parasitic infections in Brazil. Human visceral leishmaniasis (HVL) control is particularly fraught with intricacies. It is against a backdrop of decentralized health care that the complex HVL control initiatives are brought to bear. This comprehensive review aims to explore the obstacles facing decentralized HVL control in urban endemic areas in Brazil.MethodA literature search was carried out in December 2015 by means of three databases: MEDLINE, Google Scholar, and Web of Science.ResultsAlthough there have been many strides that have been made in elucidating the eco-epidemiology of Leishmania infantum, which forms the underpinnings of the national control program, transmission risk factors for HVL are still insufficiently elucidated in urban settings. Decentralized HVL epidemiological surveillance and control for animal reservoirs and vectors may compromise sustainability. In addition, it may hamper timely human HVL case management. With the burgeoning of the HIV-HVL co-infection, the potential human transmission may be underestimated.ConclusionHVL is a disease with focal transmission at a critical juncture, which warrants that the bottlenecks facing the control program within contexts of decentralized healthcare systems be taken into account. In addition, HIV-driven HVL epidemics may substantially increase the transmission potential of the human reservoir. Calculating the basic reproductive number to fine-tune interventions will have to take into consideration the specific socio-economic development context.

show abstract

“…Many difficulties permeate spatial studies because official data such those available in the SINAN are not always complete due to underreporting [ 31 , 36 ]; little information or incomplete data may leave researchers without denominators to compute the rates and the independent variables to explain the spatial causes possibly associated with morbidity and mortality [ 10 , 38 ]. The techniques used in spatial analysis tools still need to be explored in order to improve their potential to benefit health services [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Socio-environmental factors and diarrheal diseases in under five-year old children in the state of Tocantins, Brazil

Fontoura

Santos

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

BackgroundDiarrhea is a waterborne disease that affects children, especially those under 5 years of age. The objective of this study was to identify the spatial patterns of distribution of diarrheal disease in under 5-year-old children in the State of Tocantins, Brazil, from 2008 to 2013.MethodsGeoprocessing tools were used to carry out an epidemiological study, to prepare thematic maps in the TerraView 4.2.2 software based on secondary data. General indicators of the disease, presence of spatial dependence through the Global Moran’s Index (I) and the Spatial Association Index (LISA) were described.ResultsThere were 3,015 cases of under 5-year-old children hospitalized for diarrhea, with an average annual rate (AAR) of 4.10/1,000 inhabitants (inhab.). Among the main characteristics were: increasing rates in under 1-year-old children (6.16 to 9.66/1,000 inhabitants); children aged 1 to 4 full years (63%); males (55%); 8 deaths of under one-year-old children (75%); county of Araguaína (67%); incidence in the county of Nazaré (63.97/1,000 inhab.); prevalence and incidence in the Araguaína microregion (45%, AAR 9.38/1,000 inhab.). The presence of a cluster with spatial autocorrelation was found in the Araguaína microregion, which was statistically significant (I = 0.11, p-value < 0.03), with priority of intervention (Moran Map).ConclusionsThere was an increase in the number of hospitalizations for diarrhea in under 5–year-old children in the state of Tocantins. The spatial analysis identified clusters of priority areas for measures of maintenance and control of diarrheal diseases.

show abstract

Análise espaço-temporal da leishmaniose visceral no estado do Maranhão, Brasil

Cited by 16 publications

References 17 publications

Risk analysis and prediction of visceral leishmaniasis dispersion in São Paulo State, Brazil

Risk analysis and prediction of visceral leishmaniasis dispersion in São Paulo State, Brazil

Decentralized control of human visceral leishmaniasis in endemic urban areas of Brazil: a literature review

Socio-environmental factors and diarrheal diseases in under five-year old children in the state of Tocantins, Brazil

Contact Info

Product

Resources

About