Estado nutricional e distribuição de gordura corporal em crianças e adolescentes com Fibrose Cística

Chaves, Célia Regina Moutinho de Miranda; Cunha, Ana Lúcia Pereira da; Costa, Ana Carolina da; Costa, Roseli de Souza Santos da; Lacerda, Speranza Vieira

doi:10.1590/1413-812320152011.03242015

Cited by 9 publications

(4 citation statements)

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“…Studies indicate that over-nutrition is increasing in CF, and this has been linked to insulin resistance and other hormonal disturbances, which are postulated to play a role in development of diabetes and the trend of increased central fat distribution observed in this population [ 65 , 67 ]. Additionally, central adiposity, visceral adiposity, and normal weight obesity have been documented in CF and could have negative health consequences [ 28 , 33 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Evidence suggests that PwCF tend to have lower fat-free mass than healthy controls [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ] and that lower fat-free mass is associated with lower lung function in CF [ 21 , 23 , 28 , 29 , 30 , 31 ]. Other body composition abnormalities including ectopic fat deposition with fatty replacement of the pancreas, central adiposity, visceral adiposity, and normal weight obesity have been observed in CF [ 28 , 29 , 32 , 33 , 34 , 35 ]. Few studies have explored the implications of increased abdominal fat and visceral fat specific to CF; however, one cross-sectional study of adults with CF found that high levels of visceral fat in CF were associated with decreased insulin sensitivity [ 36 ].…”

Section: Overweight and Obesity In Cystic Fibrosismentioning

confidence: 99%

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The Changing Landscape of Nutrition in Cystic Fibrosis: The Emergence of Overweight and Obesity

2022

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Cystic fibrosis has historically been characterized by malnutrition, and nutrition strategies have placed emphasis on weight gain due to its association with better pulmonary outcomes. As treatment for this disease has significantly improved, longevity has increased and overweight and obesity have emerged issues in this population. The effect of excess weight and adiposity on CF clinical outcomes is unknown but may produce similar health consequences and obesity-related diseases as those observed in the general population. This review examines the prevalence of overweight and obesity in CF, the medical and psychological impact, as well as the existing evidence for treatment in the general population and how this may be applied to people with CF. Clinicians should partner with individuals with CF and their families to provide a personalized, interdisciplinary approach that includes dietary modification, physical activity, and behavioral intervention. Additional research is needed to identify the optimal strategies for preventing and addressing overweight and obesity in CF.

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Section: Discussionmentioning

confidence: 99%

Section: Overweight and Obesity In Cystic Fibrosismentioning

confidence: 99%

The Changing Landscape of Nutrition in Cystic Fibrosis: The Emergence of Overweight and Obesity

2022

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“…It is also important to evaluate FM, considering that adiposity and lung function appear to be inversely related . Abdominal fat accumulation in young and adult patients with CF seems to be correlated with chronic inflammation, physical inactivity, and growth hormone decrease . Finally, a number of risk factors for bone loss and low BMD are seen in patients with CF, including nutrition deficiency, chronic inflammation, and chronic use of glucocorticoids …”

Section: Discussionmentioning

confidence: 99%

Tools and Methods Used for the Assessment of Body Composition in Patients With Cystic Fibrosis: A Systematic Review

et al. 2019

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Background Cystic fibrosis (CF) is characterized by changes in fat mass and lean body mass that may have important prognostic value. We aim to appraise the type and frequency of application of body composition (BC) methods in child and adult patients with CF. Methods We used 4 databases (Embase, PubMed, Scopus, and Web of Science) to perform the literature search. The search was conducted from January 2017 to February 2017. Two independent reviewers selected articles based on titles and abstracts to check eligibility for inclusion. All study designs or types of articles (abstract, full text) were considered. Results Eighty‐four full‐text articles and 40 studies presented only as abstracts were selected. Sixty‐four studies included children and adolescents (age range of 0.1–18 years), and 41 studies recruited adults (range of 18–57 years); 13 studies included both age groups. Dual‐energy X‐ray absorptiometry (DXA) was used in 56 studies (33.9%), and bioelectric impedance analysis (BIA) was used in 12 studies (9.7%), whereas 38 studies (30.6%) combined different methods (up to 5 different methods) to assess BC. Conclusions The results show a large variability in the application of BC methods in patients with CF that makes the comparison between studies difficult. The only methods with a sufficient body of literature are DXA and BIA.

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“…Em um estudo realizado em 2015, na mesma instituição desta pesquisa, aferiu que a maioria dos pacientes com FC apresentam uma ingestão energética e de lipídeos inapropriado, evidenciando baixa aderência a terapia nutricional 26 .…”

Section: Discussionunclassified

Adesão de adolescentes com fibrose cística a terapia de reposição enzimática: fatores associados

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Chaves

Costa

2019

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Adesão de adolescentes com fibrose cística a terapia de reposição enzimática: fatores associadosAdherence of adolescents with cystic fibrosis to enzyme replacement therapy: associated factors Resumo O objetivo deste artigo é avaliar a prevalência e os fatores associados à adesão a terapia de reposição enzimática em adolescentes com Fibrose cística. Estudo transversal, descritivo e observacional. Foram coletados dados sociodemográficos e clínicos. Os instrumentos utilizados para avaliar adesão foram: questionário de Morisky-Green e a dispensação de medicação na farmácia e para os fatores associados, entrevista com questionário estruturado. Foram entrevistados 44 adolescentes. Segundo o método de análise de dispensação da farmácia e o questionário de Morisky-Green, encontramos uma adesão de 45,5% e 11,4%, respectivamente. A maior adesão foi observada naqueles com diagnóstico precoce e a menor nos adolescentes mais velhos e nas meninas. Os fatores com a maior prevalência de não adesão foram: não levar as enzimas ao comer fora de casa, tomar enzimas somente nas grandes refeições, função pulmonar normal, com obstrução grave e muito grave. A prevalência de adesão a enzima foi pequena. Informações relacionadas à doença e ao tratamento devem ser aprimoradas, principalmente em adolescentes mais velhos e com comprometimento da função pulmonar, com criação de estratégias e estudos longitudinais para identificar fatores que interferem na adesão. Palavras-chave Adesão à medicação, Fibrose cística e terapia de reposição de enzimasAbstract This article sets out to evaluate the prevalence and factors associated with adherence to enzyme replacement therapy among adolescents with cystic fibrosis. It is a cross-sectional, descriptive and observational study. Sociodemographic and clinical data were collected. The instruments used to assess adherence were: the Morisky-Green questionnaire and medication dispensation at the pharmacy, and interviews with structured questionnaires for the associated factors. Forty-four adolescents were interviewed. According to the method of the pharmacy medication dispensation analysis and the Morisky-Green questionnaire, the adherence of 45.5% and 11.4% was found, respectively. The higher adherence was observed in those with early diagnosis and the lowest in older adolescents and girls. The factors with the highest prevalence of non-adherence were: not taking enzymes when eating out of the home; only taking enzymes with major meals; normal lung function; with severe and very severe obstruction. The prevalence of adhesion to enzymes was low. Information related to the disease and treatment should be improved, especially among older adolescents and with impairment of lung function, with the creation of strategies and longitudinal studies to identify factors that interfere with adherence.

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Estado nutricional e distribuição de gordura corporal em crianças e adolescentes com Fibrose Cística

Cited by 9 publications

References 8 publications

The Changing Landscape of Nutrition in Cystic Fibrosis: The Emergence of Overweight and Obesity

The Changing Landscape of Nutrition in Cystic Fibrosis: The Emergence of Overweight and Obesity

Tools and Methods Used for the Assessment of Body Composition in Patients With Cystic Fibrosis: A Systematic Review

Adesão de adolescentes com fibrose cística a terapia de reposição enzimática: fatores associados

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