Diagnosis and Management of Paget's Disease of Bone - Series of 8 Cases

Abstract

Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation. It is common in the UK, Australia, New Zealand, and North America and has a strong hereditary component, affecting first- to third-degree relatives. The etiology remains unclear and treatment is based on control of the disease with bisphosphonates, with the aim of relieving symptoms and correcting laboratory abnormalities. Surgical treatment may also be necessary to correct deformities or treat pathological fractures. This study evaluated the management and course of 8 patients with Paget's disease of bone, followed in the Orthopedic Clinic of this hospital. Among these patients, 1 had concomitant advanced prostate carcinoma, highlighting the association between Paget's disease and secondary bone diseases that can affect the differential diagnosis. Level of evidence IV, Study type: Case Series.

Polyostotic Paget’s Bone Disease. A Case Depicting a Rare Mandible Lesion Location

“…Increased osteoclastic activity is seen on the affected regions, followed by abnormal bone deposition, resulting in a disarranged bone architecture with reduced durability. The most common theory suggests an interaction of genetic, viral and environmental factors [1][2]. The bones typically involved in PBD include the pelvis, the spine, both femora and the bones of the skull, but PBD may be observed to any other skeletal region [2,4].…”

“…Paget's bone disease (PBD) is a focal, progressive metabolic bone disease of unknown etiology, characterized by abnormal bone resorption and deposition. It was firstly described in 1876 by Sir James Paget [1][2]. PBD may involve a single bone (monostotic) or multiple bones (polyostotic) [3].…”

“…PBD affects usually older patients and is more frequent in male individuals with a male to female ratio of 1.8/1 and a prevalence of 2-4% to patients older than fifty years of age. On the other hand, it is rarely encountered to patients younger than this age [1]. The disease is more common in European population [1][2], followed by Australia, New Zealand and North America populations.…”

“…On the other hand, it is rarely encountered to patients younger than this age [1]. The disease is more common in European population [1][2], followed by Australia, New Zealand and North America populations. It is an uncommon pathological entity in Scandinavian countries, Africa and Asia [1,4].…”

“…The disease is more common in European population [1][2], followed by Australia, New Zealand and North America populations. It is an uncommon pathological entity in Scandinavian countries, Africa and Asia [1,4]. We present a case of a PBD found incidentally during a routine checkup.…”