Assessment of quality of life in patients with knee osteoarthritis

Kawano, Marcio Massao; Araújo, Ivan Luis Andrade; Castro, Martha Moreira Cavalcante; Matos, Marcos Almeida

doi:10.1590/1413-785220152306150596

Cited by 71 publications

(69 citation statements)

References 17 publications

(21 reference statements)

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“…The ARomDe score monitors the quality of life via the measurement of three dimensions, including pain and function recovery and behavior. It is consistent with many previous studies, which generally evaluate the improvement of models and human with knee osteoarthritis via the achievement of pain relief [2,7,14,19,20,26,28,29] and function recovery [1,2,26,27] and emotional behavior [1,19,20,27].…”

Section: Special Issue On "Human Stem Cells and Transplantation": Open supporting

confidence: 90%

“…It is characterized by progressive damage and loss of articular cartilage resulting in pain and disability in OA patients [1,2]. The patients greatly suffered in their activities of daily living (walking, stair climber) and declined in the quality of life, social interaction, mental efficiency and sleep quality [3].…”

Section: Introductionmentioning

confidence: 99%

“…The high prevalence of OA makes it recognizable as a public health hazards issue. In US, about 37% of the populations over 60 years of age are diagnosed with OA [2]. It is estimated that the incidence of disease will increase to 40% of the world population in 2025, due to aging and obesity [2,4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Phermthai¹,

Chareancholvanich²

2017

IJST

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Section: Special Issue On "Human Stem Cells and Transplantation": Open supporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Phermthai¹,

Chareancholvanich²

2017

IJST

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“…Progressive pain caused by OA disturbs patient's functional movement ability. This results in loss of workforce, and the associated psychological effects lead to impairments in working life, entertainment, social life, and the sleep pattern of the patient, which greatly compromising quality of life [11,12]. Pang et al [13] reported that impairment of quality of life is more closely correlated with pain level in comparison to other joint symptoms and the radiological degree of injury.…”

Section: Introductionmentioning

confidence: 99%

Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain

Aşkın

Özkan

Tosun

et al. 2017

The Kaohsiung J of Med Scie

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The aim of this study was to examine the neuropathic pain component of knee osteoarthritis (OA) patients and to investigate the relationship between neuropathic pain, disease stage, functional state, depression, anxiety, and quality of life. This study included 60 patients with knee OA. All demographic data and radiological results were recorded. Visual Analog Scale (VAS), Timed Up and Go Test, Chair Stand Test, Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC), PainDETECT questionnaire, DN4 questionnaire, Short form-36 questionnaire, and Hospital Anxiety Depression Scale were performed for each patient. Neuropathic pain was detected in 66.7% of patients based on the PainDETECT scale and in 46.7% of patients based on DN4 scale. VAS-resting, OA grade, WOMAC scores, and SF-scores showed a significant difference in patients that detected neuropathic pain with PainDETECT (p<0.05). Based on the DN4 scale, patients with neuropathic pain had significantly higher WOMAC scores and significantly lower SF-36 scores (p<0.05). The PainDETECT questionnaire scores showed positive correlations with Timed Up-and-go Test, VAS-resting, WOMAC scores, Hospital Anxiety Depression Scale scores, and a negative correlation with all SF-36 scores (p<0.05). DN4 questionnaire scores showed a negative correlation with SF-36 scores and positive correlation with WOMAC scores (p<0.05). To conclude, it should be kept in mind that patients with knee OA who describe intense pain may have a neuropathic component involved in the clinical condition. Quality of life and functional capacity are adversely affected in patients with knee OA who have neuropathic pain. This should be taken into account while planning the treatment of these patients.

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“…OA is an age‐related degeneration of the joint articular cartilage, bone, and synovium, resulting in joint pain, inflammation, and impaired mobility (Kawano, Andrade, Cavalcante, & Almeida, ). OA affects about 9.6% of men and 18% of postmenopausal women above 60 years old (Che Ahmad Tantowi, Hussin, Lau, & Mohamed, ).…”

Section: Introductionmentioning

confidence: 99%

Vernonia amygdalina inhibited osteoarthritis development by anti‐inflammatory and anticollagenase pathways in cartilage explant and osteoarthritis‐induced rat model

Madzuki

Lau

Abdullah

et al. 2019

Phytotherapy Research

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Vernonia amygdalina (VA) is a medicinal tropical herb for diabetes and malaria and believed to be beneficial for joint pains. The antiosteorthritis effects of VA leaf in cartilage explant assays and on postmenopausal osteoarthritis (OA) rat model were investigated. The VA reduced the proteoglycan and nitric oxide release from the cartilage explants with interleukin 1β (IL‐1β) stimulation. For the preclinical investigation, ovariectomized (OVX) female rats were grouped (n = 8) into nontreated OA, OA + diclofenac (5 mg/kg), OA + VA extract (150 and 300 mg/kg), and healthy sham control. Monosodium iodoacetate was injected into the knee joints to accelerate OA development. After 8 weeks, the macroscopic, microscopic, and histological images showed that the OA rats treated with VA 300 mg/kg and diclofenac had significantly reduced cartilage erosions and osteophytes unlike the control OA rats. The extract significantly down‐regulated the inflammatory prostaglandin E2, nuclear factor κβ, IL‐1β, ADAMTS‐5, collagen type 10α1, and caspase3 in the OVX‐OA rats. It up‐regulated the anti‐inflammatory IL‐10 and collagen type 2α1 mRNA expressions, besides reducing serum collagenases (MMP‐3 and MMP‐13) and collagen type II degradation biomarker (CTX‐II) levels in these rats. The VA (containing various caffeoyl‐quinic acids, flavanone‐O‐rutinoside, luteolin, apigenin derivative and vernonioside D) suppressed inflammation, pain, collagenases as well as cartilage degradation, and improved cartilage matrix synthesis to prevent OA.

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Assessment of quality of life in patients with knee osteoarthritis

Cited by 71 publications

References 17 publications

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Quality of Life of Elderly and Obese Animal Models with Severe Knee Osteoarthritis after a Single Injection of Mesenchymal Stem Cells

Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain

Vernonia amygdalina inhibited osteoarthritis development by anti‐inflammatory and anticollagenase pathways in cartilage explant and osteoarthritis‐induced rat model

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