Thrombocytosis: A Retrospective Study of 573 Dogs (2016-2017)

Abstract

Thrombocytosis refers to the increase in number of platelets per microliter (µL) of blood. Platelet counts greater than 1,000,000/µL may be associated with clinical signs of bleeding or thrombosis. Previous studies on underlying causes of thrombocytosis have aroused the interest of researchers about its clinical importance in dogs. The objective of this study was to analyze the blood cell counts in dogs in order to define the main diseases or clinical conditions that were associated with thrombocytosis, from 2016 to 2017. This was done to determine the incidence of thrombocytosis, and categorize the increase in platelet count with respect to severity. Of the 12,676 blood samples analyzed, 4.5% presented thrombocytosis (n = 573). Similar mean platelet counts were observed in all diagnosis or different categories of clinical conditions (neoplasms; gastrointestinal, endocrine, and ophthalmological diseases; trauma and surgery; dermatological, cardiac, neurological, infectious, respiratory, genitourinary, idiopathic, and multiple diseases; and pregnancy) with no significant difference (P ≥ 0.05). The disorders most commonly associated with thrombocytosis were gastrointestinal diseases, followed by neoplasms. Furthermore, increased platelet counts were observed in dogs treated with glucocorticoids and vincristine drugs. As for the degree of severity, extreme thrombocytosis occurred more frequently in the presence of gastrointestinal diseases.

Thrombocytosis in 158 cats (2011–2018)

“…This is consistent with what has been reported in people and dogs, in which gastrointestinal disease, both nonneoplastic and neoplastic, have been commonly associated with thrombocytosis. [4][5][6][7][8]13 Neoplasia was diagnosed in slightly fewer than half of cats in this study, which was a more common diagnosis in this population of cats than has been previously reported. In a previous report of 51 If diagnoses of non-neoplastic inflammatory disease were noted affecting multiple body systems, these were both noted in the table.…”

“…In people and dogs, reactive thrombocytosis is described more commonly than primary thrombocytosis. [4][5][6][7][8] This reactive increase in circulating platelets can be transient, most often seen as a rebound effect upon recovery from events such as acute blood loss or splenectomy. 5,9 Other causes for transient thrombocytosis include physiologic mobilization of platelets from the spleen or other stores.…”

“…3,12 In dogs, several studies have identified neoplasia as the most common condition associated with thrombocytosis, though severity of thrombocytosis has not been found to be predictive of underlying diagnosis. [5][6][7][8] Within neoplastic diagnoses in dogs, carcinoma was the most common tumor type, resembling carcinoma-associated thrombocytosis in people. 6 Few studies have investigated the association between the severity of thrombocytosis and underlying conditions in cats.…”

Nefrectomía asociada con renomegalia derecha en un perro afectado por hidronefrosis

“…A troca de antibiótico mostrou-se eficaz ao se observar a contagem total de leucócitos no segundo retorno (Tabela 2, coluna Resultado no 2º Retorno). A trombocitose observada pode ocorrer como mecanismo reacional frente a doenças e alterações no funcionamento do organismo, a citar doenças endócrinas, traumas, deficiência de ferro, processos inflamatórios e hemorragia aguda (Rocha et al, 2019). As duas últimas causas são sugestivas para o quadro do paciente no primeiro retorno (Tabela 1, coluna Resultado no 1º Retorno).…”