2016
DOI: 10.1590/0104-1428.2246
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Abstract: SbstractEncapsulation of bioactive compounds has been carried out to improve bioavailability and to protect them against harm conditions. However, encapsulation processes are often aggressive and it is important that encapsulated substances keep their biological activity. In this work curcumin was nanoencapsulated using dichloromethane as solvent and ultrasound as dispersion device. Nanoparticles were obtained using different curcumin concentrations and encapsulants (PLLA and Eudragit S100) and the encapsulati… Show more

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Cited by 27 publications
(15 citation statements)
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“…This peak was also visible in the physical mixture but absent in the lutein-loaded nanoparticles. This fact is indicative of the efficient encapsulation of compounds inside the encapsulation matrix (Dandekar, Jain, Patil, Dhumal, & Tiwari, 2010;Mohan, Gupta, Jaggi, & Chauhan, 2010;da Silva-Buzanello et al, 2016;Yallapu, Jaggi, & Chauhan, 2010). The PVP thermogram showed a large endothermic peak caused by water loss (Paradkar, Ambike, Jadhav, & Mahadik, 2004) with an associated enthalpy of 314 J·g −1 .…”
Section: Resultsmentioning
confidence: 89%
“…This peak was also visible in the physical mixture but absent in the lutein-loaded nanoparticles. This fact is indicative of the efficient encapsulation of compounds inside the encapsulation matrix (Dandekar, Jain, Patil, Dhumal, & Tiwari, 2010;Mohan, Gupta, Jaggi, & Chauhan, 2010;da Silva-Buzanello et al, 2016;Yallapu, Jaggi, & Chauhan, 2010). The PVP thermogram showed a large endothermic peak caused by water loss (Paradkar, Ambike, Jadhav, & Mahadik, 2004) with an associated enthalpy of 314 J·g −1 .…”
Section: Resultsmentioning
confidence: 89%
“…On the other hand, curcumin solid dispersion is colloidally stable in water and was able to inhibit oxidative hemolysis. The antioxidant activity of curcumin has been described in the literature by conventional tests (Silva-Buzanello et al, 2016) and its activity was also demonstrated in the endogenous antioxidant system (Sankar et al, 2013). Deng et al (2006) have demonstrated that curcumin analogues can inhibit the free radical-induced oxidative haemolysis of human erythrocytes, and that the phenolic groups in these molecules play a crucial role in their antioxidant/antihaemolytic activity.…”
Section: Antihemolytic and Tbars Formation Inhibition Activitiesmentioning
confidence: 99%
“…Despite the proven efficacy of curcumin in relation to several biological activities, its low solubility decreases its bioavailability and therapeutic efficacy. However, nanoencapsulation have been used quite successfully to circumvent such low hydro solubility and/or bioavailability of curcumin (de Almeida et al, 2018;Rocha et al, 2014;Silva-Buzanello et al, 2016). Polyoxyethylene-polypropylene block copolymers surfactants (such as Poloxamer 407) are known to enhance dissolution rates and bioavailability of hydrophobic drugs (Vasconcelos et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Despite being noticeable for the physical mixture of PVP and curcumin, these bands could not be visualized in the obtained nanoparticles spectra, as exemplified with the 3510 cm -1 band in Figure 1B4, indicating that curcumin should be located inside the PVP matrix. In fact, this type of attenuation effect is often considered as an evidence of an efficient encapsulation (Gangurde, Kundaikar, Javeer, Jaiswar, Degani, & Amin, 2015;Silva-Buzanello et al, 2016;Yallapu et al, 2010).…”
Section: Characterization Of Solid Dispersion Nanoencapsulated Curcuminmentioning
confidence: 99%