Toxicological properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays

Silva, José Darlan Alves da; Nogueira, Cláudio Rodrigo; Vieira, Maria do Carmo; Vieira, Silvia Cristina Heredia; Barufatti, Alexéia; Crispim, Bruno do Amaral; Francisco, Luiza Flávia Veiga; Viana, Lucilene Finoto; Cardoso, Cláudia Andréa Lima

doi:10.1590/0103-8478cr20190091

Cited by 5 publications

(4 citation statements)

References 26 publications

(24 reference statements)

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“…Therefore, the LE-1 and LE-2 extracts were cytotoxic at the concentration assessed, with the former presenting significantly greater toxic action than the later (p ≤ 0.00). In previous studies, extracts from A. triangularis were shown to cause mortality in Artemia salina larvae, as well as being cytotoxic in an Allium cepa bioassay and towards KB cells (MONGELLI et al, 1996;SILVA et al, 2019). Conversely, the toxicological properties of A. gibertii had not been previously described in literature.…”

Section: Resultsmentioning

confidence: 97%

“…The cytotoxicity of LE-1 and LE-2 reflected their chemical compositions, since both plants selected for this work can produce compounds that are known to be cytotoxic. Nearly fifty compounds have been reported to occur in A. triangularis, among which only aristolactam I and aristolochic acids I, II, C and D, all of which are cytotoxic, were detected in leaves of this species (SILVA et al, 2019;MICHL et al, 2016). In contrast, a total of twelve chemical constituents, including the cytotoxic lignans cubebin, (-)-hinokinin, and (-)-kusunokinin, have been isolated from A. gibertii leaves (MARCHESINI et al, 2009).…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxicity and the bioconversion strategy of Aristolochia spp.

et al. 2021

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Aristolochia plants are notable from an ethnopharmacological viewpoint, but the relevance of these species for medicinal purposes has been debated because of their inherent toxicity. The convergence of these contrasting realities can be readily achieved using bioconversion methods, which have been shown to be useful tools for numerous applications, including the detoxification of biomass. In this context, methanolic extracts of leaves from Aristolochia triangularis and Aristolochia gibertii, as well as the feces of Battus polydamas larvae fed with leaves from these plants, were prepared, and their cytotoxic activities were evaluated on a human fibroblast cell line (GM07492). The leaf extracts were found to be cytotoxic, leading to reductions of 42.1 and 33.8% on cell viability, respectively, while the fecal extracts were considered inactive. In addition to evidencing the cytotoxicity of A. triangularis and A. gibertii, these findings demonstrated a potential bioconversion strategy for obtaining aristolochiaceous extracts with reduced toxicity using the larvae of a specialist phytophagous insect, thus renewing expectations in relation to the pharmacological importance of Aristolochia spp. The results were also ecologically relevant, as B. polydamas larvae were found to be able to detoxify compounds from host plants.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Cytotoxicity and the bioconversion strategy of Aristolochia spp.

et al. 2021

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“…Pesquisas realizadas no sudoeste da Nigéria revelaram a inexistência dessa toxicidade induzida por Aristolochia spp em pacientes com diabetes que faziam uso nas decocções (SULYMAN et al, 2016). De acordo com ZHOU et al (2019), são necessárias mais pesquisas, pois não há indícios epidemiológicos e experimentos em animais suficientes de que possa ter relação direta dos ácidos aristolóquicos com o câncer, havendo, Danielle BOGO então, muitas divergências entre o real poder farmacológico do gênero Aristolochia com os estudos toxicológicos apresentados de citotoxicidade e mutagenecidade (SILVA et al, 2019).…”

Section: Resultsunclassified

Uso popular de Aristolochia spp na prevenção e tratamento do câncer

Soares

Nogueira

et al. 2022

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Dentre os inúmeros gêneros de plantas que apresentam atividades biológicos, encontra-se o gênero Aristolochia. Alguns estudos demonstram que apesar de apresentar toxicidade em humanos, alguns espécies são frequentemente utilizadas no tratamento de câncer, utilizando folhas e raízes. O objetivo deste artigo foi realizar um levantamento bibliográfico nas bases de dados referente aos registros etnobotânicos, de espécies do gênero Aristolochia spp em diversas regiões do mundo. Trata-se de um artigo de revisão, de caráter integrativo, cuja coleta de informações foi obtida através de produções científicas, publicadas no período de 2010 a 2020, nas bases de dados Lilacs, Scielo, Medline; utilizando-se os seguintes termos dos Descritores em Ciências da Saúde (DeCS): aristolochia and (extracts or phytotherapy or plants, medicinal or medicine, traditional or plants or ethobotany or therapeutic use or botany or neoplasms). Foram obtidos os seguintes resultados: Pubmed: 672artigos; Lilacs: 24; Scielo: 25 e Medline: 535, perfazendo um total de 1256 artigos, sendo que destes, 518 estavam duplicados e foram rejeitados, restando apenas 738. Após análise criteriosa dos títulos e resumos de cada estudo, deste total, apenas 10, preenchiam os critérios de inclusão para o objetivo proposto. Foi possível identificar um déficit nas produções científicas diante do atual número de espécies do gênero Aristolochia spp. Ainda, apesar de haver informações toxicológicas semelhantes, há casos em que subnotifica ou não informa as reações adversas.

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“…However, it is necessary to investigate the true medicinal potential, especially concerning its toxicity profile. Despite the therapeutic reports, harmful effects have already been described and reported for plants of this genus acting as a nephrotoxic, antispermatogenic, and antifertility agent (Dey & De, 2011), in addition to demonstrating toxicity and cytotoxicity in bioassays (Silva et al, 2019).…”

Section: Rootsmentioning

confidence: 99%

The Aristolochia (Aristolochiaceae) genus: therapeutic properties, biological effects and toxicity

Mueller

Coelho

Garcia

et al. 2022

RSD

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The Brazilian flora harbors extensive plant biodiversity with the possibility of therapeutic use. In this context, the genus Aristolochia is widely used in folk medicine. From this perspective, the study aims to demonstrate important characteristics of these vegetables in the current literature. It was observed that the genus has promising medicinal properties that are directly related to its biological and chemical composition. However, it is notable that more research is needed to guide the safe use and encourage the synthesis of new pharmaceutical products derived from these herbs.

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Toxicological properties of an aqueous extract of Aristolochia triangularis leaves, using the brine shrimp lethality and Allium cepa bioassays

Cited by 5 publications

References 26 publications

Cytotoxicity and the bioconversion strategy of Aristolochia spp.

Cytotoxicity and the bioconversion strategy of Aristolochia spp.

Uso popular de Aristolochia spp na prevenção e tratamento do câncer

The Aristolochia (Aristolochiaceae) genus: therapeutic properties, biological effects and toxicity

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