MicroRNA and cancer: a focus on mammary tumors in female dogs

Salvador-Bernabé, Rosana Lino; Tinucci‐Costa, Mirela; Amorim, Renée Laufer

doi:10.1590/0103-8478cr20180196

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Intracellularly, E-cadherin is linked to the cytoskeleton by association with β, α and γ catenin suggesting that E-cadherin expression loss may be correlated with catenins phosphorylation (2). Besides that, the miRNA profiles were also investigated in canine mammary carcinoma and, miRNA-9 has been implicated in aiding metastasis by targeting the E-cadherin encoding mRNA, given that its expression levels are correlated with tumor grade and metastatic status in dogs (18,19).…”

Section: Resultsmentioning

confidence: 99%

Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors

Gomes¹,

Ferreira²,

Oliveira³

et al. 2021

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Expression of cadherins has been correlated to the development and aggressiveness of epithelial neoplasms, however, in canine mammary tumors, their significance prognostic is uncertain. Due to this fact, the expression of the intracellular adhesion molecules E and P-cadherin and correlation with overall survival were analyzed in 25 canine mammary gland tumors. E-cadherin expression reduction was correlated with histological type, high histological grade, and overall survival rate. P-cadherin staining was higher in malignant tumors, unrelated to other clinicopathological features of aggressiveness. The results of this study suggest a relationship between lower expression of E and P-cadherin and worse prognostic in canine mammary tumors, including shorter overall survival.

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Section: Resultsmentioning

confidence: 99%

Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors

Gomes¹,

Ferreira²,

Oliveira³

et al. 2021

BJVP

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show abstract

“…This mechanism may be involved in post-transcriptional physiological factors, such as miRNAs inhibiting COX-2 protein expression due to repressive capacities ( 96 – 99 ). When deregulated in the cancer context, this post-transcriptional factor is altered and no more effective in avoiding protein synthesis ( 96 , 98 , 100 ).…”

Section: Discussionmentioning

confidence: 99%

COX-2 expression in mammary invasive micropapillary carcinoma is associated with prognostic factors and acts as a potential therapeutic target in comparative oncology

et al. 2022

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Pure human and canine mammary invasive micropapillary carcinoma is a rare malignant epithelial tumor accounting for 0.9 to 2% of all invasive mammary carcinomas and present a high rate of lymphatic invasion and metastasis, with unfavorable prognosis. Surgery and chemotherapy are standard treatments for almost all mammary cancer in both species, as well as hormonal and target therapies available for human patients. However, depending on the patient's clinical staging, satisfactory therapeutic results for invasive micropapillary carcinoma are a challenge due to its high capacity of invasion and metastasis. Cyclooxygenase-2 (COX-2) isoform is an important enzyme stimulated by cytokines, growth factors and oncogenes activation to synthetizes prostaglandins in inflammatory process. COX-2 overexpression is associated with angiogenesis and invasion and contributes to cancer development, disease progression, tumor recurrence and regional lymph node metastasis in human and canine mammary carcinomas. This enzyme can be targeted by non-steroidal anti-inflammatory drugs and its inhibition can reduce tumor growth and metastasis in several cancer types. Given the similarity between both species, the present study aims to elucidate the involvement of COX-2 mRNA and protein expression in canine (cIMPC) and human (hIMPC) pure invasive mammary micropapillary carcinoma, with clinicopathological and survival data. Twenty-nine cases of cIMPC and 17 cases of hIMPC were analyzed regarding histologic type, grade, age, tumor size, lymph node condition, extracapsular extension, inflammatory infiltrate and immunophenotype. When available, information on adjuvant treatment, recurrence, metastasis and overall survival were collected. The present study demonstrated COX-2 protein expression in 65.5% of cIMPC and 92.3% of hIMPC, and an association with more advanced histological grades in bitches and higher Ki67 in women. COX-2 mRNA expression was significantly higher in cIMPC than in hIMPC, and its expression was not associated with COX-2 protein expression in both species. COX-2 mRNA expression was associated with negative-ER hIMPC as well as higher Ki67. cIMPC demonstrated proportional early development, more regional metastasis, and a prevalence of negative estrogen receptor, than hIMPC. This is the first time COX-2 expression is associated with negative prognostic factors in both cIMPC and hIMPC, besides the overexpression of COX-2 protein in such unfavorable histological type, which suggests that COX-2 can act as a potential target in IMPC.

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MicroRNA and cancer: a focus on mammary tumors in female dogs

Cited by 2 publications

References 30 publications

Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors

Prognostic impact of alterations in E-cadherin and P-cadherin expression in canine mammary tumors

COX-2 expression in mammary invasive micropapillary carcinoma is associated with prognostic factors and acts as a potential therapeutic target in comparative oncology

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