Equine nasopharyngeal cryptococcoma due to Cryptococcus gattii

Abstract

Cryptococcus gattii is often associated with pulmonary and systemic infections in humans and animals. In this research we report a case of nasopharyngeal cryptococoma caused by C. gatti in an equine. A 10-year-old mare presented a mass obstructing the oropharynx. Macroscopically the mass was asymmetric, and was attached to the ethmoidal sinuses and obstructed the oropharynx. Histopathological examination of the mass revealed multiple yeast cells ranging from spherical to oval, 4-8μm in diameter, with some of them showing narrow base polar budding. Cryptococcus gattii growth in mycological culture (Sabouraud Dextrose Agar) and was L-canavanine-glycine-bromothymol blue Agar positive. The molecular identification confirmed the isolate as C. gattii by means of the amplification of universal primers. C. gattii is considered an emerging fungal agent, as it affects human and animals and does not respond efficiently to commonly established treatments.

Emergence of Cryptococcus spp. in Donkeys in Egypt: A Potential Public Health Concern

“…gattii serotype (B) from Egypt was detected in an HIV patient (Mansour et al, 2006). This serotype has also been identified as a potential main agent of granulomatous rhinitis in horses (Cruz et al, 2017). Species identification was necessary because C. gattii infections are increasingly considered alarming as it becomes more difficult to handle this fungus, because it is not susceptible to the most widely used antifungal agents (Trilles et al, 2004), as well as this pathogen infects the immunocompetent hosts, particularly children.…”

Granulomatous rhinitis by Neoconidiobolus lamprauges in a mule

“…As a result, the differential diagnoses of rhinitis causes in horses must be differentiated of Basidiobolus ranarum (JOhNSON et al, 2021), Rhinosporidium seeberi (ARGENTA et al, 2018), P. insidiosum (SOUTO et al, 2016;TONPITAK et al, 2018), Alternaria spp., Pseudallescheria boydii (MORE et al, 2019) and Cryptococcus spp. (CRUZ et al, 2017). Other conditions that affect the nasal cavity of horses include congenital nasal cysts, inflammatory polyps, nasal amyloidosis, neoplasms, nasal granulomas caused by hypersensitivity and progressive ethmoidal hematoma (MORE et al, 2019;NICKELS, 1993).…”