Renal injury in female dogs with pyometra

Figueiredo, Mariana da Silva de; Malm, Christina; Mamão, Leonardo Dias; Oliveira, Juliana de; Veado, Júlio César Cambraia; Costa, Mariana de Pádua; Horta, R.S.; Castro, Marina Lopes; Castro, Aline Gomes de; Sbaraini, Leila; Souza, Eliana Matias de

doi:10.1590/0103-8478cr20160325

Cited by 3 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are similar to Figueiredo et al. (2017), who stated that patients with CEH–pyometra had an acute injury even without changes in creatinine. It justifies that, even animals with creatinine within the reference limits, may have unidentified acute kidney injury, as also stated by Dahlem et al.…”

Section: Discussionsupporting

confidence: 91%

“…Even in animals considered NAZO, SDMA values increased, as only 33.3% of the bitches had creatinine measurements above the stipulated limits. These results are similar to Figueiredo et al (2017), who stated that patients with CEH-pyometra had an acute injury even without changes in creatinine. It justifies that, even animals with creatinine within the reference limits, may have unidentified acute kidney injury, as also stated by Dahlem et al (2017), who concluded that serum SDMA is a positive biomarker of acute kidney injury.…”

Section: Discussionsupporting

confidence: 90%

“…The toxic effects of bacteria associated with pyometra can result in poor renal perfusion and decreased glomerular filtration rate, culminating in acute kidney injury (Ahuja et al., 2019; Figueiredo et al., 2017; Kumar et al., 2016; Trautwein et al., 2018). Furthermore, glomerular and tubular dysfunction in the kidneys can lead to azotemia in patients with CEH–pyometra (Heiene et al., 2007; Sant'Anna et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Renal biomarkers, clinical parameters, and renal Doppler velocimetry in bitches with cystic endometrial hyperplasia–pyometra complex

dos Santos Silva,

Trautwein,

Hidalgo

et al. 2023

Reprod Domestic Animals

View full text Add to dashboard Cite

Cystic endometrial hyperplasia (CEH)–pyometra complex is the most common uterine infection in adult and elderly bitches and can cause renal dysfunction. The aim of this study was to measure and compare urinary creatinine, urea, symmetric dimethylarginine (SDMA), urinary protein–creatinine ratio (UPC), measurement of systolic blood pressure (SBP), and Doppler velocimetry of renal arteries in patients with CEH–pyometra complex before and after an average of 6 months of treatment, evaluating the possibility of the changes persisting. The evaluation was conducted at two moments: M1 (at the diagnosis of CEH–pyometra, n = 36) and M2 (after an average of six months of treatment, n = 16). For the control group, eight bitches with no changes in blood tests or history of conditions underwent Doppler ultrasound evaluation of the renal arteries. At both M1 and M2, we measured creatinine, urea, and serum SDMA, UPC, SBP, and Doppler ultrasound of the renal arteries. Patients were evaluated according to the following groups: azotemic (AZO) and non‐azotemic (NAZO), and open and closed cervix pyometra. The parameters were compared between animals present in both moments presented as M1R (bitches that were in M1 and M2) and M2. Statistical significance was considered when p < .05. The medians found for creatinine in M1 were as follows: 1.15 mg/dL, being 1.8 mg/dL for AZO (12/36) and 0.95 mg/dL for NAZO (24/36); and in M2: 0.85 mg/dL (16/16), being 1.15 mg/dL for AZO (4/16) and 0.8 mg/dL for NAZO (12/36). For urea, in M1 it was 36 mg/dL (32/36), with AZO being 103 mg/dL (11/32) and 33 mg/dL in NAZO (21/32); and in M2 32 mg/dL (16/ 16), being 29 mg/dL for AZO (4/36), and 31 mg/dL for NAZO (3/15). The median SDMA measured in M1R was 17 μg/dL (15/16), with AZO being 31 μg/dL (3/15), and NAZO being 16.5 μg/dL (12/15); and in M2, SDMA was 12 μg/dL (16/16), with AZO being 12.5 μg/dL (4/16), and NAZO being 12 μg/dL (12/16). The median UPC measured in M1 was 1.15 (10/36), with AZO being 0.25 (1/10), and NAZO being 1.38 (9/10); and in M2, it was 0.2 (13/16), being 0.1 in AZO (4/13), and 0.2 (9/16) in NAZO. For SBP, in M1, it was 118 mmHg (30/36), with AZO being 102 mmHg (10/30) and 133 mmHg in NAZO (20/30); and in M2 142.5 mmHg (12/16), being 155 mmHg for AZO (4/12), and 140 mg/dL for NAZO (8/12). When comparing animals with open and closed cervixes, a difference was found between SDMA measurements (p = .001). There was a distinction between PI and RI of the left and right kidneys consecutively (p = .007; p = .033; p = .019; p = .041). Correlations found in M1: SDMA × PI RIM DIR (r = 0.873; p = .002), SDMA × PSV RIM ESQ (r = 0.840; p = .004), SDMA × EDV RIM ESQ (r = 0.675; p = .046). With this study, we conclude a return to normality of renal biomarkers and clinical parameters after six months. Yet, there is a persistence of Doppler velocimetric measurements between the two moments. Thus, this parameter is not suitable for identifying and classifying chronic kidney injury in bitches with pyometra.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal biomarkers, clinical parameters, and renal Doppler velocimetry in bitches with cystic endometrial hyperplasia–pyometra complex

dos Santos Silva,

Trautwein,

Hidalgo

et al. 2023

Reprod Domestic Animals

View full text Add to dashboard Cite

show abstract

The evaluation of SIRS status with hemato-biochemical indices in bitches affected from pyometra and the Usefulness of these indices as a potential diagnostic tool

et al. 2022

View full text Add to dashboard Cite

Acute phase proteins, hematological and serum biochemical profiles of female dogs in diestrus, mucometra and pyometra

Friolani,

Santana,

Voorwald

et al. 2024

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Blood samples from 200 female dogs divided into 6 groups (diestrus, mucometra, pyometra) were evaluated, with the pyometra group categorized according to the ASA classification (American Society of Anesthesiologists), that is, from ASA II to V, totaling six groups. Aiming to analyze the acute phase proteins (APP), hematological and serum biochemical profiles of the female dogs in the study, establishing the differential diagnosis and prognosis according to the group. The SDS-PAGE method was used for protein fractionation, complete blood count using an automated hematological analyzer and histogram, biochemical tests performed using a semi-automatic spectrophotometer and measurement of serum concentrations of sodium and ionic calcium using the selective ion method. The results showed that female dogs with pyometra categorized in the ASA II to V classification revealed biochemical alterations between the study groups, as well as the acute phase proteins, presented variations according to the systemic involvement, degree of inflammatory response and ASA classification of the female dogs with pyometra, in which ceruloplasmin (p=0.07) and transferrin (p=0.07) did not show statistical significance, but showed an increase in their concentration according to the inflammatory evolution, albumin (p<0.0001), IgGCP (p <0.0001), haptoglobin (p<0.0001), alpha acid glycoprotein (p<0.0001), IgGCL (p<0.0001) and the one identified by its atomic weight 23,000 Da (p=0.0031), enabling the assessment of the acute phase response and aiding in the early detection of the systemic inflammatory response and better therapeutic guidance for the patient.

show abstract

Renal injury in female dogs with pyometra

Cited by 3 publications

References 10 publications

Renal biomarkers, clinical parameters, and renal Doppler velocimetry in bitches with cystic endometrial hyperplasia–pyometra complex

Renal biomarkers, clinical parameters, and renal Doppler velocimetry in bitches with cystic endometrial hyperplasia–pyometra complex

The evaluation of SIRS status with hemato-biochemical indices in bitches affected from pyometra and the Usefulness of these indices as a potential diagnostic tool

Acute phase proteins, hematological and serum biochemical profiles of female dogs in diestrus, mucometra and pyometra

Contact Info

Product

Resources

About