Hydroxyapatite-lignin composite as a metallic implant-bone tissue osseointegration improver: experimental study in dogs

Valente, Fabrício Luciani; Santos, Luiz Carlos Oliveira dos; Sepúlveda, Rodrigo Viana; Gonçalves, Gustavo Pereira; Eleotério, Renato Barros; Reis, Emily Correna Carlo; Borges, Andréa Pacheco Batista

doi:10.1590/0103-8478cr20150110

Cited by 10 publications

(8 citation statements)

References 18 publications

(19 reference statements)

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“…3a. The spectrum of the hydroxyapatite synthesized from eggshell was similar to those found in [57]. By analyzing the spectrum, it was observed the absorptions relative to the phosphate group, with the characteristic group PO 4…”

Section: Resultssupporting

confidence: 62%

Obtaining hydroxyapatite with different precursors for application as a biomaterial

et al. 2019

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The hydroxyapatite (HAp) is a ceramic biomaterial with wide application in the bone regeneration. It can be obtained by different routes and different precursors. In this study, the synthesis of HAp was carried out by precipitation and subsequent thermal treatment using different calcium precursors: calcium hydroxide from synthetic origin and calcium oxide obtained from the eggshell. The obtained materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared (FTIR) spectroscopy. By SEM, variations of the crystal size and the concentration of agglomerates were observed. FTIR and XRD analyses proved the formation of HAp and how the (mineral and biological) precursors affected the microstructure. The thermal decomposition process of the calcium oxide obtained from the eggshell showed to be more effective for the synthesis of the hydroxyapatite, resulting in more stable morphology and microstructure.

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Section: Resultssupporting

confidence: 62%

Obtaining hydroxyapatite with different precursors for application as a biomaterial

et al. 2019

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“…Whereas the osteoconduction, which is characterized as the ability to drive or direct the neobone formation over and between the structure of the filling material, was not observed in most groups and, in particular, in the group where the rod is formed only with polymer, fact which differs from results found in the literature 16,17 , for example, Nacer et al…”

contrasting

confidence: 72%

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Santos

Facco

Ortiz³

et al. 2017

Acta Cir. Bras.

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IVBehavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal 1 4-Experimental SurgeryActa Cir Bras. 2017;32(2):116-124 AbstractPurpose: To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods: Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimental groups: group A -doped castor bean polymer with bioactive glass; group B -castor bean polymer and; group C -castor bean polymer doped with bioactive glass and hydroxyapatite. After 15 and 60 evaluation days, the femurs were removed and sent for histology and scanning electron microscopy. Results: Initially mild and moderate inflammatory infiltrate is observed that decreases as time goes by, and the presence of connective tissue capsule around the graft in all groups. Regarding the biomaterials resorption little was observed. The implanted rods did not favor the osteoconductive process in the femoral medullary canal which was observed only in the C15 group. Conclusion:The association of castor bean polymer, bioactive glass and hydroxyapatite was biocompatible and osteointegrable. The osteoconductive only occurred in the presence of hydroxyapatite and bioactive glass (C15 Group) and little biodegradation was observed.

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“…Lignin nanotubes were synthesized as carriers for gene delivery and concentrations of up to 90 mg/mL of these lignin nanotubes were found to be tolerated for human HeLa cells, which is 10 times higher than those for carbon nanotubes . Lignin/hydroxyapatite composites were engineered for bone tissue engineering, and such lignin-containing biomaterials not only exhibited a good biocompatibility with MSCs in vitro but also demonstrated osteoconductivity and osseointegration properties in vivo …”

Section: Resultsmentioning

confidence: 99%

Engineering Poly(lactide)–Lignin Nanofibers with Antioxidant Activity for Biomedical Application

Kai

Ren

Tian

et al. 2016

ACS Sustainable Chem. Eng.

219

145

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Biodegradable poly(lactic acid) (PLA)−lignin composites are considered to be promising renewable plastic materials toward a sustainable world. The addition of lignin to PLA may assist to combat the oxidative stress induced by PLA as biomaterials. In this study, PLA−lignin copolymers with various contents of alkylated lignin (10−50%) were synthesized by ring-opening polymerization. The molecular weight of such copolymers ranged from 28 to 75 kDa, while the PLA chain length varied from 5 to 38. These PLA−lignin copolymers were further blended with poly(Llactide) (PLLA) and fabricated into nanofibrous composites by electrospinning. The PLLA/PLA−lignin nanofibers displayed uniform and bead-free nanostructures with fiber diameter of 350−500 nm, indicating the miscibility of PLLA and lignin copolymers in nanoscale. Unlike bulk materials, incorporation of PLA−lignin copolymers did not enhance the mechanical properties of the nanofibrous composites. Antioxidant assay showed that the lignin copolymers and PLLA/PLA−lignin nanofibers rendered excellent radical scavenging capacity for over 72 h. Moreover, three different types of cells (PC12, human dermal fibroblasts, and human mesenchymal stem cells) were cultured on the electrospun nanofibers to evaluate their biocompatibility. Lignin-containing nanofibers exhibited higher cell proliferation compared to neat PLLA nanofibers. PLLA/ PLA-Lig20 nanofibers displayed the best biocompatibility as it achieved a balance between the antioxidant activities and the cytotoxicity. With excellent antioxidant activities and good biocompatibility, the PLLA/PLA−lignin electrospun nanofibers hold great potential to be used as biomedical materials for protecting cells from oxidative stress conditions.

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Hydroxyapatite-lignin composite as a metallic implant-bone tissue osseointegration improver: experimental study in dogs

Abstract: Hydroxyapatite-lignin composite as a metallic implant-bone tissue osseointegration improver: experimental study in dogs.

Cited by 10 publications

References 18 publications

Obtaining hydroxyapatite with different precursors for application as a biomaterial

Obtaining hydroxyapatite with different precursors for application as a biomaterial

Behavior study of the doped castor bean polymer rod with bioactive glass and hidroxyapatite in mice femur medullary canal

Engineering Poly(lactide)–Lignin Nanofibers with Antioxidant Activity for Biomedical Application

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