Pythium insidiosum colitis in a dog: treatment and clinical outcome

Fujimori, Mahyumi; Lopes, Erika Rondon; Lima, Samara Rosolem; Paula, Daphine Ariadne Jesus de; Almeida, Arleana do Bom Parto Ferreira de; Colodel, Edson Moleta; Pescador, Caroline Argenta; Néspoli, Pedro Eduardo Brandini; Dutra, Valéria; Souza, Roberto Lopes de; Sousa, Valéria Régia Franco

doi:10.1590/0103-8478cr20150081

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…Few single case reports have documented treatment success with marginal surgical excision and medical treatment using a combination of potassium iodide, itraconazole, and terbinafine, or Pythium immunotreatment, itraconazole, and terbinafine . Another case report described a positive response to medical treatment without surgical resection in a dog with gastric pythiosis after administration of itraconazole, terbinafine, and mefonoxam .…”

Section: Discussionmentioning

confidence: 99%

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Reagan

Marks

Maggiore

et al. 2019

Veterinary Internal Medicne

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Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti‐inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. This report describes 3 dogs with colonic pythiosis in which complete resolution of clinical signs, regression of colonic masses, and progressive decreases in serological titers were observed after treatment with itraconazole, terbinafine, and corticosteroids. This treatment protocol represents a promising treatment for dogs with GI pythiosis in which surgical intervention is not feasible.

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Section: Discussionmentioning

confidence: 99%

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Reagan

Marks

Maggiore

et al. 2019

Veterinary Internal Medicne

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“…Pyogranulomatous gastroenteritis caused by Pythium insidiosum has been described in horses (Bezerra Júnior et al, 2010), sheep (Pessoa et al, 2012), cats (Rakich et al, 2005) and dogs (Galiza et al, 2014;Fujimori et al, 2016). However, we did not find any reports of enteric pythiosis resulting in intestinal intussusception in Veterinary Medicine literature.…”

mentioning

confidence: 58%

“…The jejunal intussusception possibly occurred as a result of the changes in peristalsis promoted by the injured ileum-cecum-colic segment. Gastrointestinal pythiosis in dogs is typically characterized by a marked mural thickening of the affected segments of stomach or intestine (Galiza et al, 2014;Fujimori et al, 2016), and rarely the esophagus or pharynx. These cases are usually fatal because diagnosis is typically made when lesions have reached an advanced stage and surgical excision is no longer feasible (Hensel et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Intestinal intussusception secondary to enteritis caused by Pythium insidiosum in a bitch: case report

Firmino

Frade

Alves

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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We report a case of intestinal intussusception secondary to enteritis caused by Pythium insidiosum infection in a 1-year-old mixed breed bitch that died after a 30-day history of bloody diarrhea, anorexia, weight loss, listlessness, dehydration, and pale mucous membranes. Necropsy revealed two areas of intussusception, one jejunum-jejunal and one ileum-cecum-colic. The first intussusception showed slight congestion of the intestinal loop, which was resolved by manual traction, while the second intussusception exhibited thickening, irregular yellow spots, and transmural congestion. Histologically, the jejunum-jejunal segment had ischemic lesions secondary and ileum-cecum-colic intussusception there was also necrotizing, pyogranulomatous enteritis associated with negative images of intralesional fungal hyphae that were well visualized by silver impregnation. Immunohistochemistry identified the hyphae as Pythium insidiosum. The diagnosis was made based on the histological changes and confirmed by immunohistochemistry. We can conclude that enteritis by P. insidiosum in dogs can occasionally cause intestinal intussusception and result in acute death.

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“…The success of treatment in one of the case was probably due to the initial stage of infection. Fujimori et al (2016) also reported the efficacy of partial surgical enterectomy followed by itraconazole treatment in cases of colitis caused by Pythium insidiosum.…”

Section: Discussionmentioning

confidence: 99%

Pythiosis in dogs in the semiarid region of Northeast Brazil

et al. 2017

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RESUMO.-[Pitiose em cães na região semiárida do Nordeste, Brasil.] Descrevem-se os aspectos epidemiológicos, clínicos e patológicos de cinco casos de pitiose em cães na região semiárida do Nordeste. A doença ocorreu em cães com idade entre um e três anos, fêmeas e machos, de diferentes raças. Os cães eram criados em zona urbana, mas ocasionalmente eram levados para zona rural e tinham contato com áreas alagadas. Em um caso não havia informações no histórico sobre acesso à zona rural. Os principais sinais clínicos observados foram perda de peso, vômito, diarreia e tenesmo.Macroscopicamente havia espessamento da parede do intestino com massas firmes, irregulares, com áreas granulares amareladas entremeadas por tecido esbranquiçado, no duodeno, cólon e reto, que se estendia ao pâncreas e linfonodos, além de fígado e vagina. Na pele havia área de alopecia e ulcerações irregulares, algumas contendo pequenas cavitações com secreção serosanguinolenta. Microscopicamente havia inflamação piogranulomatosa e em um caso também havia necrose eosinofílica associada a imagens negativas tubuliformes pela hematoxilina e eosina, fortemente impregnadas pelo GMS e fracamente coradas pelo PAS. As hifas foram fortemente imunomarcadas pela imuno-histoquímica com anticorpo policlonal anti-Pythium insidiosum. A doença ocorre esporadicamente em cães no semiárido nordestino, entretanto deve ser incluída no diagnostico diferencial das doenças em cães com evolução crônica e proliferativa que acometem o sistema gastrintestinal, e frente a lesões cutâneas de difícil tratamento. We describe the epidemiological, clinical and pathological features of five cases of pythiosis in dogs in northeast semiarid. The disease occurred in dogs with age between one and three years, females and males of different breeds. The dogs were created in urban areas, but were occasionally taken to the countryside and then had contact with wetlands. The main clinical signs were weight loss, vomiting, diarrhea and tenesmus. Macroscopically there were intestinal wall thickening with irregular firm masses with yellowish granular areas interspersed with a whitish tissue, involving the duodenum, colon and rectum, extending to the lymph nodes and pancreas, and the vagina and liver. In the skin there were areas of alopecia and irregular ulcerations, some containing small cavitations with serosanguineous secretion. Microscopically there were pyogranulomatous inflammation and in one case also there were eosinophilic necrosis associated with negative images tubuliformes by hematoxylin and eosin, strongly stained by GMS and weakly by PAS. Hyphae were strongly marked by immunohistochemistry with polyclonal anti-Pythium insidiosum. The disease occurs sporadically in dogs in the semiarid Northeast, however should be included in the differential diagnosis of chronic diseases and proliferative aspect of the gastrointestinal system, and front skin lesions of difficult treatment.

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Pythium insidiosum colitis in a dog: treatment and clinical outcome

Cited by 8 publications

References 11 publications

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone

Intestinal intussusception secondary to enteritis caused by Pythium insidiosum in a bitch: case report

Pythiosis in dogs in the semiarid region of Northeast Brazil

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