Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis

Abstract

The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with w-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with w-3 PUFAs (AP+O). The administration of w-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with w-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues.

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

“…Our findings are consistent with those of a number of other studies on antioxidant therapy that have reported reduced activity and reduced cell infiltration of inflammatory mediators in experimentally induced AP models in rats . Azuma et al .…”

“…A recent study by Azuma et al . studied the influence of omega‐3 fatty acids on serum triglyceride levels in rats with AP. Their findings showed that omega‐3 fatty acids reduce the triglyceride levels that have already been altered by AP.…”

Low Dietary n-6/n-3 PUFA Ratio Regulates Meat Quality, Reduces Triglyceride Content, and Improves Fatty Acid Composition of Meat in Heigai Pigs

“…We also found that high n-3 PUFA and low n-6/n-3 PUFA ratio diet reduced TC and TG contents. These results were consistent with the previous findings that n-3 PUFA could help to reduce TG and TC contents [23,24]. These data suggest that high n-3 PUFA and low n-6/n-3 PUFA ratio diets could help us to produce pork meat with low TC and TG contents.…”

Improvement in serum lipids and liver morphology after supplementation of the diet with fish oil is more evident under regular feeding conditions than under high-fat or mixed diets in rats

“…FOs rich in n-3 FAs are known to reduce serum TG [45]. Such an effect was demonstrated under both SD and HFD conditions [42] but also under various other conditions: administration of 3 g/kg/day FO for 3 months decreased fasting plasma TG by 39% in a diabetes mellitus model [46]; after only 8 days of n-3 PUFA administration, serum and hepatic TG content decreased in rats treated with 0.5 mg/kg/day dexamethasone for 15 days but did not reach the control level [47], and a similar effect of dietary n-3 PUFAs was shown in rats with apical periodontitis, a condition in which serum TG is higher than in controls, but not in normal rats [48]. However, in the last-mentioned study, although the period of n-3 PUFA administration was similar to that in the present research, a 20% lower dose was used.…”