Histologic and Tomographic Findings of Bone Block Allografts in a 4 Years Follow-up: A Case Series

Deluiz, Daniel; Oliveira, Luciano Santos; Fletcher, Paul; Pires, Fábio Ramôa; Tinoco, Justine Monteiro Monnerat; Tinoco, Eduardo Muniz Barretto

doi:10.1590/0103-6440201601100

Cited by 9 publications

(4 citation statements)

References 22 publications

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“…Reports from previous studies revealed similar results in the use of CB (Deluiz et al, 2016) and DBM (Kadkhodazadeh et al, 2009). The presence of trabecular formations, presence of osteocytes and activity of osteoblastic cells.…”

Section: Discussionsupporting

confidence: 71%

Comparison of Morphological Quantitative Characteristics of the Newly Formed Alveolar Bone After the Application of Demineralized Bone Matrix and Cortical Bone Allografts

et al. 2019

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The allografts were used to obtain sufficient alveolar bone tissue for proper dental implant placement. The objective of the present study was to evaluate the morphological and quantitative characteristics (cellular and collagen densities) of the newly formed alveolar bone with the application of cortical bone (CB) and demineralized bone matrix (DBM) allografts. Six samples of alveolar bone tissue from 5 patients (50 ± 6.3 years) were obtained after 6 months of application of the allografts and immediately before the placement of the dental implants. The samples were fixed (buffered formaldehyde, pH7.2), decalcified (EDTA 10 %) and histologically processed (HE and Picro-Sirius) for histologic analysis. Morphological analysis revealed presence of osteocytes and trabeculae in neoformed bone tissue near the allografts and absence of inflammatory and allergic cells; the remnants of CB were located mainly in the periphery of the bone tissue and the remnants of DBM were more incorporated into the tissue. Osteogenitor cells were observed around the remaining material. The cell density was not modified in newly formed bone tissue with the application of both allografts as compared to mature bone tissue. The density of the type I and III collagens present in the osteoids interspersed with the remainder of the materials showed a tendency to increase in the samples treated with DBM. It was concluded that by the histological characteristics observed both grafts were biocompatible, however the bone treated with DBM presented better incorporation and a tendency of increase of the collagen content in the remnant region of the allografts.

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Section: Discussionsupporting

confidence: 71%

Comparison of Morphological Quantitative Characteristics of the Newly Formed Alveolar Bone After the Application of Demineralized Bone Matrix and Cortical Bone Allografts

et al. 2019

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“…In addition, signs of vascularization were observed in all evaluated specimens. 16 In 2012, Nissan et al performed histological and histomorphometric examinations of cylindrical sample cores collected from regions grafted with cancellous bone block during implant placement.…”

Section: ⅲ Discussionmentioning

confidence: 99%

Maxillary Anterior Implant-supported Restorations with Allogeneic Block-bone Graft: A Report of Two Clinical Cases

Pyo¹,

Kim²,

Chang³

et al. 2023

J Implantol Appl Sci

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Prosthetic rehabilitation of a severely atrophic anterior maxilla is challenging. To achieve aesthetic and functional outcomes with anterior implant-supported restorations, horizontal or vertical bone augmentation should be performed prior to implant placement. Autogenous block-bone grafting is the gold standard for onlay graft techniques; however, it is associated with problems, such as patient discomfort due to additional surgery at the intra-or extra-oral donor site. Therefore, the allogeneic block-bone graft, which is relatively less traumatic and safer, is used for convenience, and the high success rate in previous studies has proven the reliability of this technique. Herein, we report two cases in which allogeneic block-bone was successfully grafted in single and long-span defects in the maxillary anterior region, with satisfactory aesthetic and functional outcomes that were stable at regular follow-ups after surgery.

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“…Structural characteristics such as dimension of graft particles or chips are known to influence the amount of resorption and speed of new bone formation. Due to this slow particle resorption, some authors emphasise the relevance of processing in reducing immunogenic reaction that could be provided by allografts (24,25). Although in the past some cross-infection has been reported from transplantation of allografts, new high standard protocols of screening tests for donors, irradiation, and antimicrobial procedures expressively diminish antigenicity (26).…”

Section: Discussionmentioning

confidence: 99%

“…However, in the apical portion, only allografts DFDBA and FF exhibited more mineral apposition at 9 weeks compared to 6 weeks, which suggests an improvement in bone deposition and remodelling by the allografts. Despite this augmentation on mineral apposition, demineralised and frozen bone allografts generally are associated with a poor mechanical resistance (25). Conversely to orthopaedic surgery, in the great majority of oral reconstructive surgery, there is no need for high biomechanical resistance at the early stage of bone repair.…”

Section: Discussionmentioning

confidence: 99%

Growth Dynamic of Allogeneic and Autogenous Bone Grafts in a Vertical Model

Lima

Sendyk

et al. 2018

Braz. Dent. J.

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Several techniques have been proposed for vertical bone regeneration, and many of them use bone autogenous and allogeneic grafts. The purpose of this study was to compare demineralised freeze-dried bone allografts (DFDBA), fresh-frozen (FF) allografts, autogenous bone grafts to find differences between volumetric and histological quantity of bone formation and vertical bone growth dynamic. A vertical tissue regeneration bone model was performed in rabbit calvarias under general anaesthesia. Four hollow cylinders of pure titanium were screwed onto external cortical bone calvarias in eight rabbits. Each one of the cylinders was randomly filled with one intervention: DFDBA, FF, autogenous bone, or left to be filled with blood clot (BC) as control. Allogeneic grafts were obtained from a ninth animal following international standardised protocols for the harvesting, processing, and cryopreservation of allografts. Autogenous graft was obtained from the host femur scraping before adapting hollow cylinders. Animals were euthanized at 13 weeks. Vertical volume was calculated after probe device measurements of the new formed tissue inside the cylinders and after titanium cylinders were removed. Histomorphometry and fluorochrome staining were used to analyse quantity and dynamic of bone formation, respectively. Results showed that DFDBA and fresh-frozen bone improved the velocity and the quantity of bone deposition in distant portions of the basal plane of grafting. Remaining material in allograft groups was more intense than in autogenous group. Both allografts can be indicated as reliable alternatives for volume gain and vertical bone augmentation.

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Histologic and Tomographic Findings of Bone Block Allografts in a 4 Years Follow-up: A Case Series

Cited by 9 publications

References 22 publications

Comparison of Morphological Quantitative Characteristics of the Newly Formed Alveolar Bone After the Application of Demineralized Bone Matrix and Cortical Bone Allografts

Comparison of Morphological Quantitative Characteristics of the Newly Formed Alveolar Bone After the Application of Demineralized Bone Matrix and Cortical Bone Allografts

Maxillary Anterior Implant-supported Restorations with Allogeneic Block-bone Graft: A Report of Two Clinical Cases

Growth Dynamic of Allogeneic and Autogenous Bone Grafts in a Vertical Model

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