2013
DOI: 10.1590/0103-6440201302362
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Abstract: The aim of this study was to evaluate the osteocalcin immunoexpression during the bone repair treated with subcutaneous adipose tissue in rats and rabbits. Fourteen rats and 14 rabbits were used in the study. A critical-sized calvarial defect was created in each animal. The animals were divided into 4 experimental groups: RC (rat control), RbC (rabbit control), RAT (rat adipose tissue), RbAT (rabbit adipose tissue). In the groups RC and RbC the defect was filled with a blood clot. In groups RAT and RbAT, the d… Show more

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Cited by 8 publications
(16 citation statements)
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“…Osteocalcin is expressed during mineralization by osteoblastic cells. [24, 54–56]. Those evidences supported us to analyze the expression of bone extreme activities: resorption (collagen I) and formation (osteocalcin).…”
Section: Discussionmentioning
confidence: 84%
“…Osteocalcin is expressed during mineralization by osteoblastic cells. [24, 54–56]. Those evidences supported us to analyze the expression of bone extreme activities: resorption (collagen I) and formation (osteocalcin).…”
Section: Discussionmentioning
confidence: 84%
“…Previous studies have shown that several proteins and cell factors surrounding the graft, such as BMP-7, OCN, RUNX2 and TGF-β1, favor osteogenesis. [38][39][40][41] BMP-7 is an osteo-inductive morphogen that is known to be involved in embryonic skeletogenesis as well as in bone repair. Den Boer et al 39 reported that in an experimental study, callus diameter, callus volume, and bone mineral content at the fracture site were significantly increased in BMP-7 groups, compared with the no-injection control group after surgery, suggesting that BMP-7 is able to accelerate physiologic fracture healing.…”
Section: Discussionmentioning
confidence: 99%
“…The expression of Osteocalcin gene in cells which are not directly connected with bone metabolism is probably associated with constant bone remodeling processes which take place in living organism. Immune cells, which are important part of processes of skeleton destruction and healing, and cells from BEL, which overcome epithelial-to-mesenchymal transition, play significant role in metabolism of connective tissue [ 9 11 ]. This finding seems to be important due to the fact that bony material for diagnostic tests is far more difficult to obtain than blood or mucosal lining.…”
Section: Discussionmentioning
confidence: 99%
“…Osteocalcin is mainly produced by mature osteoblasts, but OC expression was also detected in other types of cells. OC immunoexpression was stated in the subcutaneous adipose tissue, used during the treatment of osteolytic bone defects [ 9 ]. What is more, the phenomenon of epithelial-to-mesenchymal transition can cause the expression of OC in epithelial tissue.…”
Section: Introductionmentioning
confidence: 99%