Radioprotective Effect of Sodium Selenite on Developing Teeth

Neves, Ellen Gaby; Ramos‐Perez, Flávia Maria de Moraes; Freitas, Deborah Queiroz; Bóscolo, Frab Norberto; Almeida, Solange María de

doi:10.1590/0103-6440201302193

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Each 2 virgin female rats were located in a cage with one male rat for 24 hours and in the next morning vaginal smears were examined andif sperm was found in the vaginal smear and vaginal plugs existed, it was considered that they had mated [19]. After mating, the male rat was removed and each female was placed in an individual cage until the end of study.…”

Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat

Mohsenzadeh

Rahmani

Cheraghi

et al. 2014

Mediators of Inflammation

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This study aimed to investigate any inflammatory effect of nicotine on rat embryo by exposing their mothers to different dosages of nicotine during pregnancy. During this experimental study, 32 pregnant healthy Wistar rats were divided into 4 equal groups, including a control and 3 nicotine exposure groups. Injections were performed subcutaneously starting at the first day of pregnancy until parturition. As the dosages of nicotine were increased, the weight gain by pregnant rats and the mean weight of their newborns were significantly reduced. Mean ± SD of hs-CRP was significantly higher among groups exposed to various dosages of nicotine (2, 4, and 6 mg/kg) compared to the control group (P < 0.0001) and its increasing rate was also dose dependent. Mean ± SD serum level of IL-6 and TNF-α among all groups exposed to nicotine, except for 2 mg/kg nicotine injected group, was increased significantly (P < 0.0001). Mean ± SD of serum level of TGF-β and nitrite oxide among exposure groups showed significant differences compared to the control group only at the dosage of 6 mg/kg (P < 0.0001). The current study showed that exposing pregnant rats to nicotine causes a dose dependent increase in the rate of all the studied inflammatory serum markers among their newborns.

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Section: Methodsmentioning

confidence: 99%

Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat

Mohsenzadeh

Rahmani

Cheraghi

et al. 2014

Mediators of Inflammation

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“…Each of the two virgin female rats was located in a cage with one male rat for 24 h, and the vaginal smears of female rats were examined the following morning. In case any sperms were observed in the vaginal smears and if vaginal plugs existed, the female rats were considered as pregnant [23]. After mating, the male rat was removed and each female rat was placed in an individual cage until the end of the study.…”

Section: Animalsmentioning

confidence: 99%

“…Changes in the atrophicity of heart and arteries, particularly an increase in the WT and a decrease in the arterial diameter, play an important role in determining the extent of vasoconstriction and vasorelaxation of arterial walls as well as the composition of cellular and noncellular components of arterial walls. BP could be the result of the aforementioned structural changes [23,24]. As already mentioned, no comprehensive study has yet reported the effect of PA on the cardiac structure and NO activity of mature neonates during pregnancy.…”

Section: Introductionmentioning

confidence: 98%

Prenatal Exposure to Phthalic Acid Induces Increased Blood Pressure, Oxidative Stress, and Markers of Endothelial Dysfunction in Rat Offspring

et al. 2015

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Previous studies have reported the harmful effects of exposure to phthalic acid (PA) on heart. No studies have reported the effects of prenatal PA exposure on the structure or function of heart. The current study aimed to investigate the effects of prenatal PA exposure on the markers of oxidative stress and cardiac structure in rats' offspring. Twenty-four pregnant rats were randomly categorized into three groups of control, exposed to 2.5 and 5 % PA. The morphometric properties of coronary arteries, markers of oxidative stress, and NOS activity were measured in offspring rats. By a dose-dependent manner, the body weight (BW), heart weight (HW), and HW/BW of the intervention groups were reduced and their heart rate and blood pressure were conversely increased compared to the control group. Also, the wall thickness, cross-sectional area of the aorta and septal branch of the descending left coronary artery were significantly increased in the intervention group. In addition, PA significantly increased the level of malondialdehyde and decreased the level of superoxide dismutase and glutathione peroxidase, compared to the control group. This study revealed that prenatal exposure of rats to PA causes vascular dysfunction, increasing oxidative stress, and reduction in cardiac nitric oxide synthetase activity among offspring rats.

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“…Care of animals and practices were provided with the Animal House, Faculty of Medicine (Girls), Al-Azhar University, Cairo, according to the Guide of the Care and Use of Laboratory Animals [11]. Each male rat was located with 2 virgin female rats in a cage for 24 h. In the morning, the first day of pregnancy was determined by the presence of the vaginal plug [16]. Each pregnant female was placed in an individual cage until the end of study.…”

Section: Animalsmentioning

confidence: 99%

Biochemical and histological study on the effect of levetiracetam on the liver and kidney of pregnant albino rats

2019

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Background: Levetiracetam is a broad-spectrum antiseizure agent and one of the most commonly prescribed drugs for epilepsy. The aim of this work was to assess the effect of levetiracetam at its therapeutic range on the liver and kidney of pregnant albino rats. Materials and methods: Forty pregnant rats were divided equally into two groups (I-II), Rats in the group I were gavaged 1.5 mL/day distilled water in two divided doses throughout pregnancy. Rats in the group II were gavaged 1.5 mL/day distilled water (containing 36 mg levetiracetam) in two divided doses throughout pregnancy. At the end of the experiment, blood samples were taken and the sera were separated and used for biochemical analysis. The kidneys and livers of both groups were excised and used for light and electron microscopic examination. Results: Treatment with levetiracetam induced undesirable histopathological changes in the liver and kidney of pregnant albino rats. These changes were in the form of distortion of the hepatic architecture, dilatation of the central and the portal veins, widening of the Bowman's spaces, thickening and disruption of the glomerular basement membrane, fusion and effacement of secondary foot processes, cytoplasmic vacuolation, and swollen mitochondria with loss of their cristae. Such changes were confirmed by alteration of certain biochemical parameters related to the liver and kidney functions. Conclusions: Levetiracetam induced deleterious effects on the liver and kidney of pregnant albino rats. Further investigations are recommended to clarify the mechanism of levetiracetam toxicity. (Folia Morphol 2019; 78, 4: 809-817)

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Radioprotective Effect of Sodium Selenite on Developing Teeth

Cited by 6 publications

References 25 publications

Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat

Prenatal Exposure to Nicotine in Pregnant Rat Increased Inflammatory Marker in Newborn Rat

Prenatal Exposure to Phthalic Acid Induces Increased Blood Pressure, Oxidative Stress, and Markers of Endothelial Dysfunction in Rat Offspring

Biochemical and histological study on the effect of levetiracetam on the liver and kidney of pregnant albino rats

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