Physicochemical Properties of a Methacrylate-Based Dental Adhesive Incorporated with Epigallocatechin-3-gallate

Neri, Jiovanne Rabelo; Yamauti, Mónica; Feitosa, Victor Pinheiro; Pires, Amanda Pontes Maia; Araújo, Rinaldo dos Santos; Santiago, Sérgio Lima

doi:10.1590/0103-6440201300096

Cited by 17 publications

(17 citation statements)

References 23 publications

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“…The results presented in this study are consistent with Neri, et al 30 (2014), who observed that adhesives with EGCG concentrations at 0.01 wt% and 0.1 wt% did not differ in flexural strength or percentage of water sorption of the adhesives, which showed no differences in their physical or chemical properties at these different concentrations. EGCG is known to promote collagen cross-linking through hydrogen bonding, thus improving collagen properties such as modulus of elasticity 9 .…”

Section: Discussionsupporting

confidence: 92%

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Mechanical-physicochemical properties and biocompatibility of catechin-incorporated adhesive resins

et al. 2019

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Several anti-proteolytic dentin therapies are being exhaustively studied in an attempt to reduce dentin bond degradation and improve clinical performance and longevity of adhesive restorations.ObjectivesThis study assessed the effect of epigallocatechin-3-gallate (EGCG) on long-term bond strength when incorporated into adhesives.Material and MethodsAdhesive systems were formulated with EGCG concentrations of 0 wt%: (no EGCG; control); 0.5 wt% EGCG; 1.0 wt% EGCG, and 1.5 wt% EGCG. Flexural strength (FS), modulus of elasticity (ME), modulus of resilience (MR), compressive strength (CS), degree of conversion (DC), polymerization shrinkage (PS), percentage of water sorption (%WS), percentage of water solubility (%WL) and cytotoxicity properties were tested. Dentin microtensile bond strength (µTBS) was evaluated after 24 h and again after 6 months of water storage. The adhesive interface was analyzed using scanning electron microscopy (SEM).ResultsNo significant differences were found among the groups in terms of FS, ME, MR, CS and PS. EGCG-doped adhesives increased the DC relative to the control group. EGCG concentrations of 1.0 wt% and 0.5 wt% decreased the WS of adhesives. WL decreased in all cases in which EGCG was added to adhesives, regardless of the concentration. EGCG concentrations of 1.0 wt% and 0.5 wt% reduced cytotoxicity. EGCG concentrations of 1.0 wt% and 0.5 wt% preserved µTBS after 6 months of storage, while 1.5 wt% EGCG significantly decreased µTBS. SEM: the integrity of the hybrid layer was maintained in the 0.5 wt% and 1.0 wt% EGCG groups.ConclusionEGCG concentrations of 1.0 wt% and 0.5 wt% showed better biological and mechanical performance, preserved bond strength and adhesive interface, and reduced cytotoxicity.

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Section: Discussionsupporting

confidence: 92%

“…The physical and mechanical properties of adhesives strongly depend upon the degree of conversion 30 . Therefore, higher values of mechanical and physical properties were expected for EGCG-doped adhesives due to the possible hydrogen bond established between EGCG and Bis-GMA.…”

Section: Discussionmentioning

confidence: 99%

Mechanical-physicochemical properties and biocompatibility of catechin-incorporated adhesive resins

et al. 2019

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“…At concentrations of 0.5% and 1% (w/v), EGCG incorporated in an adhesive resin could increase the bond strength values and the longevity of adhesive-dentin bond for 6-12 months [44,45]. In contrast to the previous investigation, the addition of 0.01 and 0.1% (w/v) of EGCG to adhesive-resin compounds did not affect the resin-dentin bond, but could reduce the solubility of the adhesive-resin in water [42]. Yu et al [46] showed that EGCG, in addition to its antibacterial activity, increases the bond strength of root canal sealer to dentin.…”

Section: Dentin Modifier Dentin Pretreatment Collagen Cross-linkingcontrasting

confidence: 62%

“…In addition to those properties, EGCG was incorporated in dental adhesive-resins for its inhibitory effects of matrix-metalloproteinases (MMPs) and cysteine cathepsins. Indeed, those proteins are major players in the degradation and perturbation of the resin-dentin interface [42,43].…”

Section: Dentin Modifier Dentin Pretreatment Collagen Cross-linkingmentioning

confidence: 99%

Polyphenols in Dental Applications

2020

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(1) Background: polyphenols are a broad class of molecules extracted from plants and have a large repertoire of biological activities. Biomimetic inspiration from the effects of tea or red wine on the surface of cups or glass lead to the emergence of versatile surface chemistry with polyphenols. Owing to their hydrogen bonding abilities, coordination chemistry with metallic cations and redox properties, polyphenols are able to interact, covalently or not, with a large repertoire of chemical moieties, and can hence be used to modify the surface chemistry of almost all classes of materials. (2) Methods: the use of polyphenols to modify the surface properties of dental materials, mostly enamel and dentin, to afford them with better adhesion to resins and improved biological properties, such as antimicrobial activity, started more than 20 years ago, but no general overview has been written to our knowledge. (3) Results: the present review is aimed to show that molecules from all the major classes of polyphenolics allow for low coast improvements of dental materials and engineering of dental tissues.

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“…Du et al 37 reported that the incorporation of epigallocatechin-3-gallate (EGCG), which is a GA derivate into a dental adhesive, had favorable therapeutic effects such as increased antibacterial activity as well as improved microtensile bond strength. In another study by Neri et al 38 the addition of EGCG into a self-etch bonding agent showed no adverse effects on the degree of conversion and flexure strength values. Hu et al 39 investigated the physical properties of glass ionomer cements after the addition of EGCG and revealed improved flexural strength and surface hardness values in comparison with those of the control groups.…”

Section: Discussionmentioning

confidence: 92%

Effect of gallic acid addition on some mechanical properties of self-adhesive resin cements

2019

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Self-adhesive resin cements (RCs) activate matrix metalloproteinase (MMP) and cathepsin-related collagen degradation, and gallic acid (GA) inhibits the activity of both MMPs and cysteine cathepsins. The purpose of this study was to evaluate the setting time, biaxial flexural strength, and Vickers hardness of self-adhesive RCs after the addition of two different concentrations of GA. RelyX U200 (3M ESPE) and Panavia SA (Kuraray) were modified with 0.5 and 1 wt% GA. The setting time of five samples in each RC group was assessed using a thermocouple apparatus as described in the ISO 4049 test. Biaxial flexure strength was measured using a universal testing machine until failure. Vickers hardness was measured with three randomized indentations on the surface of each resin disc. RCs without GA were used as control.Data were analyzed using a one-way analysis of variance and Tukey's HSD test (α = 0.05). The setting times ranged from 2.4 to 4.6 min for RelyX and from 4.9 to 6.0 min for Panavia. The biaxial flexure strength ranged from 76.5 to 109.7 MPa for RelyX and from 73.3 to 108.2 MPa for Panavia. Vickers hardness values ranged from 41.6 to 58.6 for RelyX and 27.2 to 33.6 for Panavia. The addition of 0.5 and 1 wt% GA to improve durability of resin-dentin bonds had no adverse effects on setting time, whereas the biaxial flexure strength and Vickers hardness values for the tested materials were significantly reduced.

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Physicochemical Properties of a Methacrylate-Based Dental Adhesive Incorporated with Epigallocatechin-3-gallate

Cited by 17 publications

References 23 publications

Mechanical-physicochemical properties and biocompatibility of catechin-incorporated adhesive resins

Mechanical-physicochemical properties and biocompatibility of catechin-incorporated adhesive resins

Polyphenols in Dental Applications

Effect of gallic acid addition on some mechanical properties of self-adhesive resin cements

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