Obstructive sleep apnea: acute effects of CPAP on polyssonographic variables

Abstract

Introduction The use of non-invasive ventilation in the form of continuous positive airway pressure (CPAP) is among the main therapeutic options for patients with obstructive sleep apnea (OSA). Yet the effects of CPAP obtained on the first night of use are underreported. Objective To evaluate the acute effects of CPAP on polysomnographic variables in patients with OSA. Materials and methods This study is a case series with 31 patients (55.8 ± 11.4 years; 22 men) in the initial phase of CPAP treatment. The subjects were evaluated by means of polysomnography with and without CPAP (10.2 ± 3.1 cmH2O) and without CPAP, on different days, by means of the following variables: sleep stages 1, 2 and 3 (N1, N2 and N3), rapid eye movement (REM) sleep, apnea and hypopnea index (AHI), AHI in REM sleep (AHIREM) and the micro-arousal index (MAI). Results The use of CPAP resulted in a reduction of N2 (p < 0.001), AHI (p < 0.001), AHIREM (p < 0.001) and MAI (p = 0.001). There was an increase in N3 (p = 0.006) and REM sleep (p < 0.001) during the night with use of CPAP. Conclusion This study demonstrated that, from the first night of use by patients with OSA, CPAP promotes greater balance between sleep phases, and improves sleep quality. These results should be presented to patients and their families in order to encourage greater adherence in the initial phase of treatment with CPAP.

Obstructive sleep apnea syndrome among obese individuals: A cross-sectional study

“…After analyzing the data, OSAS is classified according to the number of respiratory events and the apnea--hypopnea index (AHI): it is considered mild when 5 to 15 events/hour are recorded; moderate is 15 to 30 events/hour; and severe is a mean of ≥ 30 events/hour. [5][6][7][8][9][10][11] Individuals may have distinct symptoms, namely excessive daytime sleepiness, depressive states, impaired memory and learning abilities, poor concentration and attention span, and cardiovascular diseases, which can culminate in sudden death. OSAS is a progressive chronic disease that directly influences quality of life, given that sleep is a brain function that is essential to life and aids in relieving human stress.…”

Síndrome de hipoventilação da obesidade e estratégia ventilatória mais eficaz: pressão positiva contínua nas vias aéreas ou ventilação mecânica não invasiva?

“…Quando acompanhada a aplicação do CPAP, logo na primeira noite de sua utilização, promove um maior equilíbrio entre as fases e melhora a qualidade do sono de pacientes com SAOS [18]. O CPAP mostrou ter efeitos positivos em pacientes com SAOS e hipertensão persistente, na metanálise de seis ensaios clínicos, incluídos de maneira aleatória, para avaliar sua eficácia [4].…”