2020
DOI: 10.1590/0102-672020200003e1525
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Abstract: Background: Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and esophagogastric varices, characterizing gastropathy. Aim: To evaluate the use of carvedilol as primary prophylaxis in the development of collateral circulation in rats submitted to the partial portal vein ligament (PPVL) model. Method: This is a combined qualitat… Show more

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Cited by 2 publications
(3 citation statements)
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“…Portal hypertension is one of the diseases with multiple complications, including cirrhosis, schistosomiasis, retroperitoneal and biliopancreatic tumors, as well as adjacent arterial aneurysms and right heart failure 4 , 5 , 19 . With the increase in pressure, the PV system is reorganized, with the increase in caliber of the veins, such as PV (>13 mm), SMV, and SV (>10 mm), associated with splenomegaly 5 , 19 .…”
Section: Discussionmentioning
confidence: 99%
“…Portal hypertension is one of the diseases with multiple complications, including cirrhosis, schistosomiasis, retroperitoneal and biliopancreatic tumors, as well as adjacent arterial aneurysms and right heart failure 4 , 5 , 19 . With the increase in pressure, the PV system is reorganized, with the increase in caliber of the veins, such as PV (>13 mm), SMV, and SV (>10 mm), associated with splenomegaly 5 , 19 .…”
Section: Discussionmentioning
confidence: 99%
“…O envolvimento hepatoesplênico crônico descreve uma ampla gama de manifestações clínicas importantes, sendo a hipertensão portal o principal fator de morbimortalidade nesses pacientes. Com a evolução crônica da doença, esses pacientes podem desenvolver ascite, esplenomegalia, trombose portal, varizes de esôfago e estômago, sendo a hemorragia digestiva alta a principal causa de mortalidade 2,3,4,15,18 . Por esse motivo, o desenvolvimento de métodos para o diagnóstico precoce das complicações e o tratamento eficaz são prioridades na literatura médica atual.…”
Section: Introductionunclassified
“…Chronic hepatosplenic involvement describes a wide range of important clinical manifestations, with portal hypertension being the main cause of morbidity and mortality in these patients. With the chronic evolution of the disease, these patients may develop ascites, splenomegaly, portal thrombosis, and esophageal and stomach variceal, with upper digestive hemorrhage being the major cause of mortality 2 , 3 , 4 , 15 , 18 . For this reason, the development of methods for early diagnosis of complications and effective treatment is the priority in the current medical literature.…”
Section: Introductionmentioning
confidence: 99%