Activity of Orbignya Phalerata and Euterpe Edules in the Prevention and Treatment of Peptic Ulcer in Rats

Torres, Orlando Jorge Martins; Santos, Orlando José dos; Moura, Roberto Soares de; Serra, Humberto Oliveira; Ramos, Vanisse Portela; Melo, Syomara Pereira da Costa; Loureiro, Carlos

doi:10.1590/0102-672020180001e1390

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Medicinal plants possessing active principles such as flavonoids, saponins, tannins, and terpenes are found to show antiulcer activity [6]. Leaf crude decoction of Jasminum grandiflorum [7], Orbignya phalerata and Euterpe edulis [8], Lafoensia pacari A. St.-Hil [9], An ethnobotanical survey done in Ethiopia [25,30] expressed that the leaves of U. simensis are given orally for 2 to 3 days for therapy of peptic ulcer diseases. To the best of our in-depth search, the latest surveys expressed that no animal experimentation data was available on the antiulcer activity of U. simensis.…”

Section: Introductionmentioning

confidence: 99%

Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

Sisay

Andargie

Molla

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Urtica simensis has been used for the treatment of peptic ulcer disease in Ethiopian folkloric medicine by drinking its juice after boiling the semicrushed leaf. To our latest understanding, no in vivo study was available regarding its antiulcer activity. The present study was done to appraise the ulcer-protective and ulcer healing activity of hydromethanolic crude extract of leaf of U. simensis in rats. Methods. Preliminary qualitative phytochemical screening and oral acute toxicity were carried out using a standard protocol. To validate U. simensis in vivo antiulcer potential pyloric ligature, cold restraint stress and acetic acid-induced ulcer models were employed. The extracts (100, 200, and 400 mg per kg of body weight per day), standard treatment (omeprazole 20 mg/kg/day), and vehicle (distilled water 10 ml/kg/day) were given to treatment, positive, and negative controls by oral gavage, respectively. Parameters were then evaluated accordingly after the humane scarification of rats. Results. Any sign of toxicity was not observed in the oral acute toxicity test. The crude extracts exerted a significant ( P < 0.05 ) inhibition of ulcer risk compared to the negative control. In the pylorus ligation-induced ulcer model, its antisecretory activity was in a dose-dependent manner. The highest gastroprotective effect (67.68%) was exhibited by the 400 mg/kg/day dose of 80% methanolic crude extract. Regarding the chronic ulcer model, treatment at a dosage of 100, 200, and 400 mg/kg/day cures ulcers by 33.54%, 58.33%, and 67.07%, respectively, as compared to the negative control groups remarkably. Conclusion. The findings of the present study confirmed the safety and a promising in vivo ulcer healing and antiulcerogenic activity of U. simensis, thus supporting the traditional claim. In-depth investigations on the plant, however, are highly recommended.

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Section: Introductionmentioning

confidence: 99%

Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

Sisay

Andargie

Molla

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Medicinal plants possessing active principles like flavonoids, saponins, tannins, and terpenoids are found to have anti-ulcer activity. 10 Leaf crude extract of Jasminiumgradiflorum, 11 Orbignyaphalerata and Euterpe edulis, 12 Azadirachta indicia, 13 Papaya carica, 14 and ribwort L. 15 possess anti-ulcer activity. Leaf crude extract of Diodiasarmentosa (Rubiaceae), Cassia nigricans (Celsapinaceae), Ficus exasperate (Moraceae) and Synclisiascabrida (Menispermaceae) are the most popularly used anti-ulcer recipes in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

<p>Evaluation of the Anti-Ulcer Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of <em>Rumex nepalensis</em> in Rats</p>

Sisay¹,

Aragaw²

2020

JEP

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Background: Rumex nepalensis(RN) Spreng has been used to treat ulcer disease in Ethiopian folk medicine. This study aimed to determine the anti-ulcer activity of hydroalcoholic root crude extract and solvent fractions of R. nepalensis in rats. Methods: The effect of R. nepalensis crude hydromethanolic extract and solvent fractions at doses (100, 200, 400 mg/kg/day) and repeated dosing (200 mg/kg/day for 10 and 20 days) was examined on ulcers in rats in pyloric ligation-, cold restraint stress-, and acetic acidinduced ulcer models. Cimetidine (100 mg/kg/day) and/or Omeprazole (20 mg/kg/day) were used as standard drugs and served as a positive control. Data were analyzed by one-way ANOVA post hoc followed by a Tukey HSD test with SPSS software version 24.0, and P≤ 0.05 was considered as statistically significant. Results: In the pylorus ligation-induced ulcer model, pretreatment with the crude extract significantly reduced the degree of gastric secretions, pH, total acidity, and ulcerations in a dose-dependent manner. Gastroprotection offered by the R. nepalensis 400 mg/kg test extract was comparable to that of the standard. Among fractions, the ethyl acetate fraction at 400 mg/kg had the highest protection of ulcer but the chloroform fraction was ineffective. In the cold restraint stress-induced ulcer model, R. nepalensis at 200 and 400 mg/kg reduced the lesion index significantly (P<0.01). With relevant chronic ulcer model treatment, a dose of R. nepalensis at 200 and 400 mg/kg healed ulcers significantly with a curative ratio of 53.22% and 54.59%, respectively. Conclusion: From this study, it is concluded that hydromethanolic crude extract and solvent fractions of R. nepalensis root showed promising anti-ulcer activity. This upholds its folkloric use. Thus, it is considered as a possible source to develop a new anti-ulcer agent.

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Effects of Juçara (Euterpe edulis Martius) on Health: An Overview of Clinical and Experimental Studies and Call for Action

Siqueira

Lopes

et al. 2023

Nutrients

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Background and aims: Juçara is a fruit of ecological and nutritional importance. Its fruits represent an option for the sustainable use of the plant due to its vulnerability to extinction. Thus, the aim of this review was to analyze clinical and experimental studies and highlight the literature gaps regarding the effects of supplementation with Juçara on health. Methods: For this scoping review, we consulted the Medline (PubMed), Science Direct, and Scopus databases in March, April, and May 2022. Experimental studies and clinical trials published in the last ten years (2012–2022) were analyzed. Data were synthesized and reported. Results: A total of 27 studies were included, 18 of which were experimental studies. Of these, 33% evaluated inflammatory markers associated with fat accumulation. Most of these studies (83%) used pulp in lyophilized form, and the others (17%) involved juçara extract mixed in water. In addition, 78% of the studies showed positive results with respect to the lipid profile, reduction of oncological lesions, inflammation, microbiota modulation, and improvement in obesity and glycemia-related metabolic complications. Nine clinical trials with results similar to those of experimental trials were found. The majority (56%) were chronic (four to six weeks into the intervention), and 44% were acute. Three offered juçara supplementation in the form of juice, four used freeze-dried pulp, two used fresh pulp, and one used a 9% dilution. The dose was fixed at 5 g, but the dilution ranged from 200 to 450 mL. These trials assessed mainly healthy, physically active, and obese individual adults (19–56 years old), and cardioprotective and anti-inflammatory effects, as well as improvement in the lipid profile and prebiotic potential, were observed. Conclusion: Juçara supplementation showed promising results with respect to its effect on health. However, further studies are needed to clarify these possible effects on health and their mechanisms of action.

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Activity of Orbignya Phalerata and Euterpe Edules in the Prevention and Treatment of Peptic Ulcer in Rats

Cited by 3 publications

References 21 publications

Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

Hydromethanolic Crude Extract of the Leaf of Urtica simensis Hochst. ex. A. Rich. (Urticaceae) Acquires Appreciable Antiulcer Effect: Validation for In Vivo Antiulcer Activity

<p>Evaluation of the Anti-Ulcer Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of <em>Rumex nepalensis</em> in Rats</p>

Effects of Juçara (Euterpe edulis Martius) on Health: An Overview of Clinical and Experimental Studies and Call for Action

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