Prognostic Factors for Left Colectomy for Colon Cancer: A Ten Years Experience of a Single University Institution

Nahas, Sérgio Carlos; Nahas, Caio Sérgio Rizkallah; Bustamante-Lopez, Leonardo Alfonso; Pinto, Rodrigo Ambar; Marques, Carlos Frederico Sparapan; Campos, Fábio Guilherme; Cecconello, Ivan

doi:10.1590/0102-6720201700020006

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The only report we found on prognostic risk factors in patients with left-side CRC after surgery showed that the prognosis was only related to staging. [8][9][10]51 CC is one of the most rapidly increasing types of right colon cancer with a poor prognosis, and our study will contribute to the development of this field.…”

Section: Discussionmentioning

confidence: 82%

Competitive Risk Analysis of Prognosis in Patients With Cecum Cancer: A Population-Based Study

Yang

et al. 2021

Cancer Control

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Background: The presence of competing risks means that the results obtained using the classic Cox proportional-hazards model for the factors affecting the prognosis of patients diagnosed with cecum cancer (CC) may be biased. Objective: The purpose of this study was to establish a competitive risk model for patients diagnosed with CC to evaluate the relevant factors affecting the prognosis of patients, and to compare the results with the classical COX proportional risk model. Methods: We extracted data on patients diagnosed with CC registered between 2004 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. The univariate analysis utilized the cumulative incidence function and Gray’s test, while a multivariate analysis was performed using the Fine-Gray, cause-specific (CS), and Cox proportional-hazards models. Results: The 54463 eligible patients diagnosed with CC included 24387 who died: 12087 from CC and 12300 from other causes. The multivariate Fine-Gray analysis indicated that significant factors affecting the prognosis of patients diagnosed with CC include: age, race, AJCC stage, differentiation grade, tumor size, surgery, radiotherapy, chemotherapy and regional lymph nodes metastasis. Due to the presence of competitive risk events, COX model results could not provide accurate estimates of effects and false-negative results occurred. In addition, COX model misestimated the direction of association between regional lymph node metastasis and cumulative risk of death in patients diagnosed with CC. Competitive risk models tend to be more advantageous when analyzing clinical survival data with multiple endpoints. Conclusions: The present study can help clinicians to make better clinical decisions and provide patients diagnosed with CC with better support.

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Section: Discussionmentioning

confidence: 82%

Competitive Risk Analysis of Prognosis in Patients With Cecum Cancer: A Population-Based Study

Yang

et al. 2021

Cancer Control

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“…In our previous publications we studied the division of the right and left colon cancer 24 , 25 . In a more recent paper, Benedix et al 3 found a need for a further subdivision of RCC and LCC.…”

Section: Discussionmentioning

confidence: 99%

Is There a Difference Between Right- Versus Left-Sided Colon Cancers? Does Side Make Any Difference in Long-Term Follow-Up?

Bustamante-Lopez

Nahas

et al. 2019

ABCD, arq. bras. cir. dig.

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Background:Since 1990 it was proposed that distal and proximal location of colon cancer might follow different biological, epidemiology, pathology and prognosis, probably due to embryologic different development of the two segments of the colon, which may represent two separate disease entities. These differences might have consequences for the treatment of patients with colorectal cancer. Aim:To compare the characteristics between patients with right and left colon cancer, with severity and tumor characteristic that influence in the survival of these patients. Method:Were evaluated the outcomes of surgical treatment of patients with colon cancer with data collected retrospectively from prospectively collected database. Results:The tumor’s side did not influence survival time of patients with colon cancer (p=0.112) in the regression model. Only the diseases stage leads to influence on survival time; patients with right colon cancer have more advanced staging (III or IV) and present a risk of death greater in 3.23 times. Conclusion:This analysis provides evidence that the prognosis of localized left-sided colon cancer is better compared to right-sided colon cancer. Also, the patients with right colon cancer have more advanced stage, mucinous tumor and are older.

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Prognostic Factors for Left Colectomy for Colon Cancer: A Ten Years Experience of a Single University Institution

Cited by 2 publications

References 21 publications

Competitive Risk Analysis of Prognosis in Patients With Cecum Cancer: A Population-Based Study

Competitive Risk Analysis of Prognosis in Patients With Cecum Cancer: A Population-Based Study

Is There a Difference Between Right- Versus Left-Sided Colon Cancers? Does Side Make Any Difference in Long-Term Follow-Up?

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