Correlation Between Pre and Postoperative Levels of GLP-1/GLP-2 and Weight Loss After Roux-en-Y Gastric Bypass: A Prospective Study

Cazzo, Everton; Gestic, Martinho Antônio; Pareja, José Carlos; Chaim, Élinton Adami; Geloneze, Bruno; Barreto, Maria Rita Lazzarini; Magro, Daniéla Oliveira

doi:10.1590/0102-6720201600040010

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…This has been linked to the hyperplasia of jejunal mucosa reported in several studies (12,13,57), including the present one, resulting in an increase of villi height in the common and alimentary limbs (56) as well as mucosal volume and weight (12). This trophic effect may be mediated by glucagon-like peptide-2, which has been reported to be overexcreted in animal models and in humans (15,16). We also observed a hyperplasia in the common limb and even in the ileum (Fig.…”

Section: Discussionmentioning

confidence: 54%

Effect of different bariatric surgeries on dietary protein bioavailability in rats

Tessier

Ribeiro-Parenti

Bruneau

et al. 2019

American Journal of Physiology-Gastrointestinal and Liver Physi

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Bariatric surgery may induce protein malabsorption, although data are scarce. This study aims at evaluating dietary protein bioavailability after different bariatric surgeries in rats. Diet-induced obese Wistar rats were operated for vertical sleeve gastrectomy (VSG) or Roux-en-Y gastric bypass (RYGB). The control group was composed of pair-fed, sham-operated rats (Sham). Two weeks after surgery, rats were fed a 15N protein meal. Protein bioavailability was assessed by determination of 15N recovery in the gastrointestinal tract and organs 6 h after the meal. Fractional protein synthesis rate (FSR) was assessed using a flooding dose of 13C valine. Weight loss was the highest in RYGB rats and the lowest in Sham rats. Surprisingly, RYGB (95.6 ± 0.7%) improved protein digestibility ( P = 0.045) compared with Sham (93.5 ± 0.5%) and VSG (93.8 ± 0.6%). In contrast, 15N retained in the liver ( P = 0.001) and plasma protein ( P = 0.037) was lower than in Sham, with a similar trend in muscle ( P = 0.052). FSR was little altered by bariatric surgery, except for a decrease in the kidney of RYGB ( P = 0.02). The 15N distribution along the small intestinal tissue suggests that dietary nitrogen was considerably retained in the remodeled mucosa of RYGB compared with Sham. This study revealed that in contrast to VSG, RYGB slightly improved protein digestibility but altered peripheral protein bioavailability. This effect may be ascribed to a higher uptake of dietary amino acids by the remodeled intestine. NEW & NOTEWORTHY Using a sensitive 15N meal test, we found that gastric bypass slightly improved protein digestibility compared with sleeve gastrectomy or control but, in contrast, lowered protein retention in the liver and muscles. This paradox can be due to a higher uptake of dietary nitrogen by the intestinal mucosa that was hypertrophied. This study provides new insight on the digestive and metabolic fate of dietary protein in different models of bariatric surgery in rats.

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Section: Discussionmentioning

confidence: 54%

Effect of different bariatric surgeries on dietary protein bioavailability in rats

Tessier

Ribeiro-Parenti

Bruneau

et al. 2019

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Several studies document the influence of weight loss in improving the quality of life 2 , 9 , 13 , 16 , 18 , 26 . This improvement was described by Hachem and Brennan 16 in a systematic review finding that bariatric surgery produced better results compared with other treatments for obesity, especially in the first two years after surgery.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life After Vertical Gastrectomy Evaluated by the Baros Questionnaire

MENDES

Vargas

2017

ABCD, arq. bras. cir. dig.

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Background: The satisfactory outcome in the surgical treatment of obesity must include, in addition to weight loss, a significant change in the pre-existing comorbidities and in the quality of life. Aim: To evaluate the quality of life in the late postoperative period in patients that underwent videolaparoscopic sleeve gastrectomy. Methods: It was applied the questionnaire "Bariatric Analysis and Reporting Outcome System" (BAROS) in patients that underwent videolaparoscopic sleeve gastrectomy. Results: A total of 47 patients between 21-60 years old were evaluated. The total mean of BMI before surgery was 43.06±5.87 kg/m². The average percentage of the reduction of excess weight after surgery was 85.46±23.6%. The score obtained by patients in the questionnaire about the improvement in the quality of life showed excellent (36.17%), very good (40.43%), good (21.28%) and reasonable (2.13%) results. There was clinical improvement after surgery in all comorbidities investigated. Conclusion: The weight loss was critical to improve the quality of life and offered the resolution or clinical improvement in all of the investigated comorbidities in patients submitted to sleeve gastrectomy.

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“…It is secreted by means of proteolytic cleavage of proglucagon in response to the passage of nutrients through the distal small bowel, in a 1:1 ratio with glucagon-like peptide 1 (GLP-1) in a process mediated by enzymes proglucagon convertase 1/3 (1)(2)(3)(4)(5)(6)(7)(8) . Although the properties of GLP-2 have not been completely elucidated to date, it presents several known physiologic functions, of which the main are the trophic effect on the gut mucosa and the enhancement of nutrient absorption (5)(6)(7)(8)(9)(10)(11)(12)(13) .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Levels of C-Reactive Protein, GLP-1 and GLP-2 Among Individuals With Diabetes, Morbid Obesity and Healthy Controls: An Exploratory Study

Cazzo

Pareja

Chaim

et al. 2018

Arq. Gastroenterol.

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-Background -The glucagon-like peptides 1 and 2 (GLP-1/GLP-2) are gut hormones that may directly affect the glucose homeostasis and their activity seems to be significantly affected by chronic inflammation. Objective -To evaluate the postprandial levels of glucagon-like peptides 1 and 2 (GLP-1/GLP-2), C-reactive protein (CRP), and the postprandial glucose and insulin levels among individuals with obesity, type 2 diabetes, and healthy controls. Methods -An exploratory cross-sectional study, which involved individuals awaiting for bariatric/metabolic surgery and healthy controls. Postprandial levels of GLP-1, GLP-2, glucose, and insulin were obtained after a standard meal tolerance test. Inflammation was assessed by means of CRP. Results -There were 30 individuals enrolled in the study, divided into three groups: non-diabetic with morbid obesity (NDO; n=11 individuals), diabetic with mild obesity (T2D; n=12 individuals), and healthy controls (C; n=7 individuals). The mean CRP levels were significantly higher in the NDO group (6.6±4.7 mg/dL) than in the T2D (3.3±2.2 mg/dL) and C groups (2.5±3.2 mg/dL) (P=0.038). The GLP-1 levels following standard meal tolerance test and the area under the curve of GLP-1 did not differ among the three groups. The GLP-2 levels were significantly lower in the NDO and T2D than in the C group following standard meal tolerance test at all the times evaluated. The area under the curve of the GLP-2 was significantly lower in the NDO and T2D groups than in the C group (P=0.05 and P=0.01, respectively). Conclusion -GLP-2 levels were impaired in the individuals with obesity and diabetes. This mechanism seems to be enrolled in preventing the worsening of the glucose homeostasis in these individuals. HEADINGS -Glucagon-like peptide 1. Glucagon-like peptide 2. Diabetes mellitus. Obesity. Insulin resistance. Incretins.

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Correlation Between Pre and Postoperative Levels of GLP-1/GLP-2 and Weight Loss After Roux-en-Y Gastric Bypass: A Prospective Study

Cited by 10 publications

References 22 publications

Effect of different bariatric surgeries on dietary protein bioavailability in rats

Effect of different bariatric surgeries on dietary protein bioavailability in rats

Quality of Life After Vertical Gastrectomy Evaluated by the Baros Questionnaire

Comparison of the Levels of C-Reactive Protein, GLP-1 and GLP-2 Among Individuals With Diabetes, Morbid Obesity and Healthy Controls: An Exploratory Study

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